07.06.2013 Views

Seminari di Ematologia Oncologica - Società Italiana di Ematologia

Seminari di Ematologia Oncologica - Società Italiana di Ematologia

Seminari di Ematologia Oncologica - Società Italiana di Ematologia

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

Chen HT, McBride KM, et al. Role of genomic instability<br />

and p53 in AID-induced c-myc-Igh translocations.<br />

Nature. 2006; 440: 105-109.<br />

30. Franco S, Gostissa M, Zha S, Lombard DB, Murphy<br />

MM, Zarrin AA, et al. H2AX prevents DNA breaks from<br />

progressing to chromosome breaks and translocations.<br />

Mol Cell. 2006; 21: 201-214.<br />

31. Lenz G, Nagel I, Siebert R, Roschke AV, Sanger W,<br />

Wright GW, et al. Aberrant immunoglobulin class switch<br />

recombination and switch translocations in activated<br />

B cell-like <strong>di</strong>ffuse large B cell lymphoma. J Exp Med.<br />

2007; 204: 633-643.<br />

32. Robbiani DF, Bothmer A, Callen E, Reina-San-Martin<br />

B, Dorsett Y, Difilippantonio S, et al. AID is required for<br />

the chromosomal breaks in c-myc that lead to cmyc/IgH<br />

translocations. Cell. 2008; 135: 1028-1038.<br />

33. Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen<br />

HT, Celeste A, et al. ATM prevents the persistence and<br />

propagation of chromosome breaks in lymphocytes.<br />

Cell. 2007; 130: 63-75.<br />

34. Pasqualucci L, Dominguez-Sola D, Chiarenza A,<br />

Fabbri G, Grunn A, Trifonov V, et al. Inactivating mutations<br />

of acetyltransferase genes in B-cell lymphoma.<br />

Nature. 2011; 471: 189-95.<br />

35. Colomo L, Lopez-Guillermo A, Perales M, Rives S,<br />

Martınez A, Bosch F, et al. Clinical impact of the <strong>di</strong>fferentiation<br />

profile assessed by immunophenotyping<br />

in patients with <strong>di</strong>ffuse large B-cell lymphoma. Blood.<br />

2003; 101: 78-84.<br />

36. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD,<br />

Delabie J, Ott G, et al. Confirmarion of the molecular<br />

classification of <strong>di</strong>ffuse large B-cell lymphoma by<br />

immunohistochemistry using a tissue microarray.<br />

Blood. 2004; 103: 275-282.<br />

37. Xiao C, Srinivasan L, Calado DP, Patterson HC,<br />

Zhang B, Wang J, et al. Lymphoproliferative <strong>di</strong>sease<br />

and autoimmunity in mice with increate miR-17-92<br />

expression in lymphocytes. Nat Immunol. 2008; 9:<br />

405-414.<br />

38. Morin RD, Johnson NA, Severson TM, Mungall AJ,<br />

An J, Goya R, et al. Somatic mutations altering EZH2<br />

(Tyr641) in follicular and <strong>di</strong>ffuse large B-cell lymphomas<br />

of germinal-center origin. Nat Genet. 2010;<br />

42: 181-185.<br />

39. Tagawa H, Suguro M, Tsuzuki S, Matsuo K, Karnan S,<br />

Ohshima K, et al. Comparison of genome profiles for<br />

identification of <strong>di</strong>stinct subgroups of <strong>di</strong>ffuse large Bcell<br />

lymphoma. Blood. 2005; 106: 1770-1777.<br />

40. Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright<br />

GW et al. Oncogenic CARD11 mutations in human <strong>di</strong>ffuse<br />

large B-cell lymphoma. Science. 2008; 319: 1676-<br />

1679.<br />

41. Compagno M, Lim WK, Grunn A, Nandula SV,<br />

Brahmachary M, Shen Q, et al. Mutations of multiple<br />

genes cause deregulation of NF-kappaB in large B-celllymphoma.<br />

Nature. 2009; 459: 717-721.<br />

42. Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi<br />

Meccanismi patogenetici<br />

K, et al. Frequent inactivation of A20 in B-cell lymphomas.<br />

Nature. 2009; 430: 694-649.<br />

43. Davis RE, Ngo VN, Lenz G, Tolar P, Young RM,<br />

Romesser PB, et al. Chronic active B-cell-receptor signaling<br />

in <strong>di</strong>ffuse large B-cell lymphoma. Nature. 2010;<br />

463: 88-92.<br />

44. Honma K, Tsuzuki S, Nakagawa M, Tagawa H,<br />

Nakamura S, Morishima Y, et al. TNFAIP3/A20 functions<br />

as a novel tumor suppressor gene in several subtypes<br />

of non-Hodgkin lymphomas. Blood. 2009; 114:<br />

2467-2475.<br />

45. Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI,<br />

Hartmann S, Mechtersheimer G, et al. TNFAIP3 (A20)<br />

is a tumor suppressor gene in Hodgkin lymphoma and<br />

primary me<strong>di</strong>astinal B cell lymphoma. J Exp Med. 2009;<br />

206: 981-989.<br />

46. Novak U, Rinal<strong>di</strong> A, Kwee I, Nandula SV, Rancoita PM,<br />

Compagno M, et al. The NF-{kappa}B negative regulator<br />

TNFAIP3 (A20) is inactivated by somatic mutations<br />

and genomic deletions in marginal zone lymphomas.<br />

Blood. 2009; 113: 4918-4921.<br />

47. The International Non-Hodgkin’s Lymphoma Prognostic<br />

Factors Project. A pre<strong>di</strong>ctive model for aggressive non-<br />

Hodgkin’s lymphoma. N Engl J Med. 1993; 329: 987-<br />

994.<br />

48. Sehn LH, Berry B, Chhanabhai M, Fitzgerald C, Gill K,<br />

Hoskins P, et al. The revised International Prognostic<br />

Index (R-IPI) is a better pre<strong>di</strong>ctor of outcome than the<br />

standard IPI for patients with <strong>di</strong>ffuse large B-cell lymphoma<br />

treated with R-CHOP. Blood. 2007; 109:<br />

1857-1861.<br />

49. Lerner RE, Thomas W, Defor TE, Weisdorf DJ, Burns<br />

LJ. The International Prognostic Index assessed at<br />

relapse pre<strong>di</strong>cts outcomes of autologous transplantation<br />

for <strong>di</strong>ffuse large-cell non-Hodgkin’s lymphoma in<br />

second complete or partial remission. Biol Blood<br />

Marrow Transplant. 2007; 13: 486-492.<br />

50. Gascoyne RD, Adomat SA, Krajewski S, Krajewska M,<br />

Horsman DE, Tolcher AW, et al. Prognostic Significance<br />

of Bcl-2 Protein Expression and Bcl-2 Gene<br />

Rearrangement in Diffuse Aggressive Non-Hodgkin’s<br />

Lymphoma. Blood. 1997; 90: 244-251.<br />

51. Vitolo U, Gaidano G, Botto B, Volpe G, Au<strong>di</strong>sio E, Bertini<br />

M, et al. Rearrangements of bcl-6, bcl-2, c-myc and<br />

6q deletion in B-<strong>di</strong>ffuse large-cell lymphoma: Clinical<br />

relevance in 71 patients. Ann Oncol. 1998; 9: 55-61.<br />

52. Esteller M, Gaidano G, Goodman SN, Zagonel V,<br />

Capello D, Botto B, et al. Hypermethylation of the DNA<br />

Repair Gene O6-Methylguanine DNA Methyltransferase<br />

and Survival of Patients With Diffuse Large B-Cell<br />

Lymphoma. J Nat Cancer Ist. 2002; 94: 26-32.<br />

53. Vitolo U, Botto B, Capello D, Vivenza D, Zagonel V,<br />

Gloghini A, et al. Point mutations of the BCL-6 gene:<br />

clinical and prognostic correlation in B-<strong>di</strong>ffuse large cell<br />

lymphoma. Leukemia. 2002; 16: 668-675.<br />

54. Natkunam Y, Farinha P, Hsi ED, Hans CP, Tibshirani R,<br />

Sehn LH, et al. LMO2 protein expression pre<strong>di</strong>cts sur-<br />

15

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!