Pneumologia - Curriculum Girbino - G. Martino

TRIAL. EVALUATION OF LONGER TIME PERIODS, LARGER PATIENT NUMBERS WITH MORE SEVERE
COPD OR DURING EXACERBATIONS IS WARRANTED
Anno pubblicazione e riferimenti
RESPIRATION. 2004 MAR-APR;71(2):159-64.
ANNO: 2004 - ISBN:
Titolo
IMBALANCE OF SERUM CYTOKINE NETWORK IN SARCOID PATIENTS: INDEX OF SARCOIDOSIS
RELAPSE?
Autori
SALMERI FM, SOFO V, ANDÒ FG, VASTOLA MB, CROSCA S, BITTO A, GAETA M, GIRBINO G.
Abstract
BACKGROUND AND AIM OF THE WORK: THE FOLLOW-UP OF SARCOIDOSIS IS USUALLY PERFORMED
BY INVASIVE TOOLS SUCH AS THORACIC BIOPSY, SUPPORTED BY BRONCHO-ALVEOLAR LAVAGE
(BAL), GALLIUM-SCINTIGRAPHY AND GADOLINIUM MAGNETIC RESONANCE IMAGING (GD-MRI) TO
EVALUATE THE DEGREE OF DISEASE. ITS PATHOGENESIS CAN BE ASCRIBED TO AN ACCUMULATION
OF CELLS DUE TO THE DISREGULATION OF THE IMMUNE SYSTEM WHICH INVOLVES TH1/TH2 CELLS AS
WELL AS THE SOLUBLE FACTORS THEY GENERATE. WE EVALUATED SERUM CYTOKINE AND
MEMBRANE MARKER LEVELS (CYTOKINE NETWORK) IN SARCOID PATIENTS IN ORDER TO STUDY THE
CORRELATION WITH THE DISEASE ACTIVITY, IN PARTICULAR WITH THE OCCURRENCE OF
SARCOIDOSIS RELAPSES. PATIENTS AND METHODS: SEVEN SARCOID PATIENTS CLINICALLY STABLE
WITHOUT THERAPY, AT DIFFERENT STAGES, WERE ENROLLED IN OUR STUDY. CYTOKINE AND
MEMBRANE MARKER SERUM VALUES WERE MEASURED MONTHLY FOR 24 MONTHS, AFTER A SIX-
MONTH PERIOD OF RUN-IN, BY ELISA ASSAY AND MOAB INDIRECT IMMUNOFLUORESCENCE,
RESPECTIVELY. RESULTS: IN SOME PATIENTS AT THE FIRST AND SECOND STAGES OF THE DISEASE
WE OBSERVED MCP-1 AND INFLAMMATORY CYTOKINE PEAKS AND, MOREOVER, MCP-1 VALUES WERE
INCREASED BEFORE OTHER CYTOKINE VALUES. AFTER THREE SUBSEQUENT INCREASES OF THESE
PARAMETERS WERE OBSERVED, ACCORDING TO OUR PERSONAL EXPERIENCE, GADOLINIUM-MRI
CONFIRMED THE PRESENCE OF AN INCREASE OF THE LESION AND THEREFORE OUR HYPOTHESIS OF
SARCOIDOSIS RELAPSE. ONLY ONE PATIENT AT STAGE III SHOWED CONSTANTLY ELEVATED VALUES
OF FIBRO-ANGIOGENIC CYTOKINES AND MEMBRANE RECEPTORS OF THE TNF RECEPTOR FAMILY.
CONCLUSIONS: CYTOKINE NETWORK MONITORING COULD BE A NON-INVASIVE MEANS OF
FOLLOWING UP THE CLINICAL COURSE OF SARCOIDOSIS.
Anno pubblicazione e riferimenti
SARCOIDOSIS VASC DIFFUSE LUNG DIS. 2003 MAR;20(1):53-61.
ANNO: 2003 - ISBN:
Titolo
LE PNEUMOPATIE DA FATTORI AMBIENTALI
Autori
G.GIRBINO P.RUGGERI
Abstract
Anno pubblicazione e riferimenti
MEDICINA CLINICA – BASI BIOLOGICHE DIAGNOSTICA TERAPIA – ED. MEDICO SCIENTIFICHE TORINO 1-
36,6 ID 1732487
ANNO: 2003 - ISBN:
Titolo
LE MALATTIE PROFESSIONALI DEL POLMONE
Autori
G.GIRBINO P. RUGGERI
Abstract
Anno pubblicazione e riferimenti
LUCIO CASALI MANUALE DI MALATTIE DELL’APPARATO RESPIRATORIO . MASSON ITALIA 327-341, 1 ID
1732491
ANNO: 2002 - ISBN:
Titolo
AN OBSERVATIONAL STUDY ON THE EPIDEMIOLOGY OF RESPIRATORY TRACT BACTERIAL
PATHOGENS AND THEIR SUSCEPTIBILITY TO FOUR INJECTABLE BETA-LACTAM ANTIBIOTICS:
PIPERACILLIN, PIPERACILLIN/TAZOBACTAM, CEFTAZIDIME AND CEFTRIAXONE.
Autori
VAROTTO F, MARIA GD, AZZARO R, BELLISSIMA P, AMATO R, FOGLIANI V, MUSCIANISI G, VITALE S,
GIRBINO G, ANDÒ F, LAGANÀ P, DELIA S, JACOVIELLO C, MAIERNA G, PEZZA A, COVELLI I, MAGRÌ M,
NAPOLETANO G, ROSSI A, MARONE P, SANGUINETTI C, PELA R, TEDESCHI D,
Abstract
BACTERIAL INFECTIONS OF THE RESPIRATORY TRACT ACCOUNT FOR A LARGE PROPORTION OF
TOTAL MEDICAL CONSULTATIONS IN GENERAL PRACTICE. IN RECENT YEARS, ANTIBIOTIC
RESISTANCE HAS INCREASED ALARMINGLY IN A NUMBER OF BACTERIAL SPECIES THAT ARE COMMON
CAUSES OF THESE INFECTIONS. THE AIM OF THIS OBSERVATIONAL STUDY WAS TO DETERMINE THE
ANTIBIOTIC RESISTANCE OF MICROBIAL AGENTS ISOLATED FROM PATIENTS WITH ACUTE OR
ACUTELY EXACERBATED RESPIRATORY INFECTIONS. SUBJECTS RECRUITED AS POTENTIAL SOURCES
OF BACTERIA WERE EITHER OUTPATIENTS SEEN IN A NUMBER OF SPECIALIZED CLINICS AND
HOSPITAL PRACTICES, OR HOSPITALIZED PATIENTS. OVERALL, 648 CONSECUTIVE PATIENTS (67%
MALE, MEAN AGE 48.1+/-27.0 YEARS) WITH INFECTION OF THE UPPER OR LOWER RESPIRATORY
TRACT WERE OBSERVED DURING A 13-MONTH PERIOD. A TOTAL OF 551 PATHOGENIC MICROBIAL
STRAINS WERE ISOLATED AND TESTED FOR THEIR IN VITRO SUSCEPTIBILITY TO PIPERACILLIN,
PIPERACILLIN/TAZOBACTAM, CEFTAZIDIME, AND CEFTRIAXONE. AMONG ALL ISOLATES, THE FOUR