Pneumologia - Curriculum Girbino - G. Martino

More documents

Recommendations

Info

RIPERCUSSIONI IN TERMINI DI DIAGNOSI E MODIFICAZIONI DELL’APPROCCIO TERAPEUTICO SPECIALMENTE PER CIÒ CHE CONCERNE LA POSSIBILITÀ DI UTILIZZARE LA TERAPIA CON CORTICOSTEROIDI PER VIA INALATORIA NELLA FASE DI STABILITÀ DELLA BPCO E SISTEMICA IN CORSO DI GRAVI RIACUTIZZAZIONI. IL LINK PATOGENETICO TRA QUESTE DUE PATOLOGIE SEMBRA ESSERE RAPPRESENTATO DALL’INFIAMMAZIONE SISTEMICA, OGGI SEMPRE MEGLIO CARATTERIZZATA IN CORSO DI BPCO, CHE MEDIANTE L’AZIONE DI SPECIFICHE CITOCHINE (TNF-ALFA E IL-6) POTREBBE SPIEGARE LA PIÙ PROBABILE COMPARSA DI DIABETE IN CORSO DI BPCO. LE LINEE GUIDA ATTUALI DELLE DUE PATOLOGIE NON TENGONO IN DEBITO CONTO LA POSSIBILITÀ DI TALE ASSOCIAZIONE, SEBBENE SEMPRE MAGGIORE INTERESSE VENGA OGGI RIVOLTO AL RUOLO DELLE COMORBIDITÀ NELLA BPCO CHE, SI È VISTO,SONO IN GRADO DI MODIFICARE IN MANIERA SIGNIFICATIVA LA STORIA NATURALE DELLA MALATTIA STESSA INCIDENDO SU OUTCOME IMPORTANTI COME LA MORTALITÀ. SFORZI CONDIVISI TRA SPECIALISTI DA UN LATO (PNEUMOLOGI ED ENDOCRINOLOGI) E MEDICI DI MEDICINA GENERALE (ATTENTI OSSERVATORI DI TALE FENOMENO) DALL’ALTRO SONO NECESSARI AL FINE DI INDIVIDUARE MODALITÀ DI APPROCCIO DIAGNOSTICO E MANAGEMENT TERAPEUTICO PER TRATTARE ADEGUATAMENTE IL PAZIENTE E NON LE SINGOLE PATOLOGIE. Anno pubblicazione e riferimenti MEDIA 2008;8:137-142 ANNO: 2008 - ISBN: Titolo BRONCHITE CRONICA, BPCO ED ENFISEMA IN MALATTIE RESPIRATORIE: L'ESSENZIALE Autori G.GIRBINO, P.RUGGERI Abstract Anno pubblicazione e riferimenti MALATTIE RESPIRATORIE: L’ESSENZIALE. ELSEVIER. SETTEMBRE 2008 (PP.39-67) ANNO: 2008 - ISBN: 9788821430299 Titolo LE MALFORMAZIONI POLMONARI CONGENITE. IN: PAOLO LARIZZA. MANUALE DI MEDICINA INTERNA. Autori G.GIRBINO, P.RUGGERI Abstract Anno pubblicazione e riferimenti MANUALE DI MEDICINA INTERNA. (VOL. 1, PP. 995-1008) ANNO: 2008 - ISBN: 978-88-299-1889-8 Titolo BPCO:TERAPIA CORTISONICA NEI PAZIENTI DIABETICI Autori RUGGERI P., ALECCI U, GIRBINO G. Abstract Anno pubblicazione e riferimenti MEDIA. VOL. 8, PP. 163-167. ANNO: 2008 - ISBN: Titolo COMPARATIVE EFFECTS OF A TWO-WEEK TREATMENT WITH NEBIVOLOL AND NIFEDIPINE IN HYPERTENSIVE PATIENTS SUFFERING FROM COPD Autori CAZZOLA M, MATERA MG, RUGGERI P, SANDUZZI A, SPICUZZA L, VATRELLA A, GIRBINO G. Abstract BACKGROUND: IT HAS BEEN SUGGESTED THAT THE ANTIHYPERTENSIVE AGENT NEBIVOLOL, A BETA1- ADRENOCEPTOR-BLOCKING AGENT THAT MODULATES THE ENDOGENOUS PRODUCTION OF NITRIC OXIDE, IS PREFERABLE TO 'CONVENTIONAL' BETA1-BLOCKERS IN HYPERTENSIVE PATIENTS WITH AIRWAY DYSFUNCTION. OBJECTIVES: SINCE BETA1-BLOCKADE BY NEBIVOLOL IS LARGER AFTER REPEATED DOSING THAN AFTER A SINGLE ORAL INTAKE, WE HAVE EXPLORED ITS EFFECT ON PULMONARY FUNCTION AFTER A 2-WEEK TREATMENT IN HYPERTENSIVE PATIENTS WITH MILD TO MODERATE COPD. METHODS: A SINGLE-BLIND CROSSOVER DESIGN WAS USED. TWENTY PATIENTS WITH COPD AS SELECTED ABOVE AND WITH A DIASTOLIC BLOOD PRESSURE OF 95-110 MM HG AFTER 1 WEEK OF PLACEBO RUN-IN WERE ENTERED INTO THE TWO 2-WEEK ACTIVE TREATMENT PERIODS WITH EITHER 5 MG NEBIVOLOL (N = 10) OR 30 MG NIFEDIPINE GASTROINTESTINAL-TRANSPORT- SYSTEM (GITS) (N = 10) TAKEN FOR A PERIOD OF 2 WEEKS. AFTER A FURTHER 1-WEEK WASHOUT, SUBJECTS WERE CROSSED-OVER TO RECEIVE THE OTHER DRUG FOR 2 ADDITIONAL WEEKS. AT EACH VISIT, CHANGES IN SPIROMETRIC INDEXES AND THE INTERACTION WITH THE BRONCHODILATOR EFFECT OF SALBUTAMOL WERE INVESTIGATED. MOREOVER, SYSTOLIC AND DIASTOLIC BLOOD PRESSURE (BP) TOGETHER WITH HEART RATE WERE MANUALLY MEASURED IN ORDER TO EVALUATE THE CARDIOVASCULAR EFFECTS OF THE DIFFERENT TREATMENTS. THROUGHOUT THE STUDY, PATIENTS RECORDED SYMPTOMS. RESULTS: SIMILAR AND SIGNIFICANT REDUCTIONS IN SYSTOLIC AND DIASTOLIC BP WERE OBSERVED WITH BOTH TREATMENTS. THE IMPACT OF NIFEDIPINE ON FEV1 WAS NOT SIGNIFICANT (P > 0.05), WHILE THAT OF NEBIVOLOL WAS SLIGHT. THE MAXIMUM RESPONSE TO SALBUTAMOL WAS SLIGHTLY DECREASED WITH EITHER NEBIVOLOL OR NIFEDIPINE GITS. DAY-TO-DAY AIRWAY OBSTRUCTION CONTROL, INTERPRETED FROM PATIENT RECORDINGS OF SYMPTOM SCORES AND INHALER USE, WAS SIMILAR WITH BOTH TREATMENTS. CONCLUSIONS: OUR PILOT STUDY SUGGESTS THAT THE USE OF NEBIVOLOL IN HYPERTENSIVE PATIENTS WITH STABLE MILD TO MODERATE COPD WAS SAFE DURING A 2-WEEK
TRIAL. EVALUATION OF LONGER TIME PERIODS, LARGER PATIENT NUMBERS WITH MORE SEVERE COPD OR DURING EXACERBATIONS IS WARRANTED Anno pubblicazione e riferimenti RESPIRATION. 2004 MAR-APR;71(2):159-64. ANNO: 2004 - ISBN: Titolo IMBALANCE OF SERUM CYTOKINE NETWORK IN SARCOID PATIENTS: INDEX OF SARCOIDOSIS RELAPSE? Autori SALMERI FM, SOFO V, ANDÒ FG, VASTOLA MB, CROSCA S, BITTO A, GAETA M, GIRBINO G. Abstract BACKGROUND AND AIM OF THE WORK: THE FOLLOW-UP OF SARCOIDOSIS IS USUALLY PERFORMED BY INVASIVE TOOLS SUCH AS THORACIC BIOPSY, SUPPORTED BY BRONCHO-ALVEOLAR LAVAGE (BAL), GALLIUM-SCINTIGRAPHY AND GADOLINIUM MAGNETIC RESONANCE IMAGING (GD-MRI) TO EVALUATE THE DEGREE OF DISEASE. ITS PATHOGENESIS CAN BE ASCRIBED TO AN ACCUMULATION OF CELLS DUE TO THE DISREGULATION OF THE IMMUNE SYSTEM WHICH INVOLVES TH1/TH2 CELLS AS WELL AS THE SOLUBLE FACTORS THEY GENERATE. WE EVALUATED SERUM CYTOKINE AND MEMBRANE MARKER LEVELS (CYTOKINE NETWORK) IN SARCOID PATIENTS IN ORDER TO STUDY THE CORRELATION WITH THE DISEASE ACTIVITY, IN PARTICULAR WITH THE OCCURRENCE OF SARCOIDOSIS RELAPSES. PATIENTS AND METHODS: SEVEN SARCOID PATIENTS CLINICALLY STABLE WITHOUT THERAPY, AT DIFFERENT STAGES, WERE ENROLLED IN OUR STUDY. CYTOKINE AND MEMBRANE MARKER SERUM VALUES WERE MEASURED MONTHLY FOR 24 MONTHS, AFTER A SIX- MONTH PERIOD OF RUN-IN, BY ELISA ASSAY AND MOAB INDIRECT IMMUNOFLUORESCENCE, RESPECTIVELY. RESULTS: IN SOME PATIENTS AT THE FIRST AND SECOND STAGES OF THE DISEASE WE OBSERVED MCP-1 AND INFLAMMATORY CYTOKINE PEAKS AND, MOREOVER, MCP-1 VALUES WERE INCREASED BEFORE OTHER CYTOKINE VALUES. AFTER THREE SUBSEQUENT INCREASES OF THESE PARAMETERS WERE OBSERVED, ACCORDING TO OUR PERSONAL EXPERIENCE, GADOLINIUM-MRI CONFIRMED THE PRESENCE OF AN INCREASE OF THE LESION AND THEREFORE OUR HYPOTHESIS OF SARCOIDOSIS RELAPSE. ONLY ONE PATIENT AT STAGE III SHOWED CONSTANTLY ELEVATED VALUES OF FIBRO-ANGIOGENIC CYTOKINES AND MEMBRANE RECEPTORS OF THE TNF RECEPTOR FAMILY. CONCLUSIONS: CYTOKINE NETWORK MONITORING COULD BE A NON-INVASIVE MEANS OF FOLLOWING UP THE CLINICAL COURSE OF SARCOIDOSIS. Anno pubblicazione e riferimenti SARCOIDOSIS VASC DIFFUSE LUNG DIS. 2003 MAR;20(1):53-61. ANNO: 2003 - ISBN: Titolo LE PNEUMOPATIE DA FATTORI AMBIENTALI Autori G.GIRBINO P.RUGGERI Abstract Anno pubblicazione e riferimenti MEDICINA CLINICA – BASI BIOLOGICHE DIAGNOSTICA TERAPIA – ED. MEDICO SCIENTIFICHE TORINO 1- 36,6 ID 1732487 ANNO: 2003 - ISBN: Titolo LE MALATTIE PROFESSIONALI DEL POLMONE Autori G.GIRBINO P. RUGGERI Abstract Anno pubblicazione e riferimenti LUCIO CASALI MANUALE DI MALATTIE DELL’APPARATO RESPIRATORIO . MASSON ITALIA 327-341, 1 ID 1732491 ANNO: 2002 - ISBN: Titolo AN OBSERVATIONAL STUDY ON THE EPIDEMIOLOGY OF RESPIRATORY TRACT BACTERIAL PATHOGENS AND THEIR SUSCEPTIBILITY TO FOUR INJECTABLE BETA-LACTAM ANTIBIOTICS: PIPERACILLIN, PIPERACILLIN/TAZOBACTAM, CEFTAZIDIME AND CEFTRIAXONE. Autori VAROTTO F, MARIA GD, AZZARO R, BELLISSIMA P, AMATO R, FOGLIANI V, MUSCIANISI G, VITALE S, GIRBINO G, ANDÒ F, LAGANÀ P, DELIA S, JACOVIELLO C, MAIERNA G, PEZZA A, COVELLI I, MAGRÌ M, NAPOLETANO G, ROSSI A, MARONE P, SANGUINETTI C, PELA R, TEDESCHI D, Abstract BACTERIAL INFECTIONS OF THE RESPIRATORY TRACT ACCOUNT FOR A LARGE PROPORTION OF TOTAL MEDICAL CONSULTATIONS IN GENERAL PRACTICE. IN RECENT YEARS, ANTIBIOTIC RESISTANCE HAS INCREASED ALARMINGLY IN A NUMBER OF BACTERIAL SPECIES THAT ARE COMMON CAUSES OF THESE INFECTIONS. THE AIM OF THIS OBSERVATIONAL STUDY WAS TO DETERMINE THE ANTIBIOTIC RESISTANCE OF MICROBIAL AGENTS ISOLATED FROM PATIENTS WITH ACUTE OR ACUTELY EXACERBATED RESPIRATORY INFECTIONS. SUBJECTS RECRUITED AS POTENTIAL SOURCES OF BACTERIA WERE EITHER OUTPATIENTS SEEN IN A NUMBER OF SPECIALIZED CLINICS AND HOSPITAL PRACTICES, OR HOSPITALIZED PATIENTS. OVERALL, 648 CONSECUTIVE PATIENTS (67% MALE, MEAN AGE 48.1+/-27.0 YEARS) WITH INFECTION OF THE UPPER OR LOWER RESPIRATORY TRACT WERE OBSERVED DURING A 13-MONTH PERIOD. A TOTAL OF 551 PATHOGENIC MICROBIAL STRAINS WERE ISOLATED AND TESTED FOR THEIR IN VITRO SUSCEPTIBILITY TO PIPERACILLIN, PIPERACILLIN/TAZOBACTAM, CEFTAZIDIME, AND CEFTRIAXONE. AMONG ALL ISOLATES, THE FOUR
Page 1 and 2: FORMATO EUROPEO PER IL CURRICULUM V
Page 3 and 4: 01/11/1980 - Nome e indirizzo del d
Page 5: 01/10/1961 - 30/06/1966 Nome e tipo
Page 9 and 10: Anno pubblicazione e riferimenti AD
Page 11 and 12: Anno pubblicazione e riferimenti RI
Page 13 and 14: GRAM-NEGATIVE BACTERIA (6 KLEBSIELL
Page 15 and 16: DELL'ASMA BRONCHIALE APPROVATO DAL
Page 17: ULTERIORI INFORMAZIONI ONORIFICENZE

Pneumologia - Curriculum Girbino - G. Martino

Create successful ePaper yourself

Delete template?

Save as template?