Pneumologia - Curriculum Girbino - G. Martino

Autori
CAZZOLA M, MATERA MG, SANTANGELO G, ASSOGNA G, D'AMATO G, ROSSI F, GIRBINO G.
Abstract
IN EIGHT ASTHMATIC SUBJECTS A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY WAS
PERFORMED TO INVESTIGATE THE EFFECT OF INHALED KETANSERIN, A 5-HT2 RECEPTOR BLOCKING
AGENT, IN A DOSE OF 10 MG GIVEN 30 MIN BEFORE TEST, ON ADENOSINE-INDUCED BRONCHOSPASM.
THE PROTECTIVE EFFECT OF KETANSERIN WAS SIGNIFICANT IN ALL PATIENTS, EVEN THOUGH IT
ALTERED BASAL BRONCHOMOTOR TONE IN ONLY TWO SUBJECTS. ON THE CONTRARY, KETANSERIN
DID NOT INHIBIT HISTAMINE-INDUCED BRONCHOCONSTRICTION IN FOUR OF THESE EIGHT
ASTHMATICS, EVEN THOUGH IT MODIFIED SENSITIVITY AND REACTIVITY IN ONE OF THEM. THE
RESULTS SUGGEST THAT KETANSERIN INFLUENCE ON ADENOSINE BRONCHIAL REACTIVITY AND
SENSITIVITY WAS NOT DUE TO THE BRONCHODILATOR EFFECT OF KETANSERIN ITSELF OR TO ITS
ANTIHISTAMINIC ACTIVITY. WE HAVE NO CERTAIN EXPLANATION FOR THE INHIBITION OF ADENOSINE-
INDUCED BRONCHOCONSTRICTION ELICITED BY KETANSERIN. IT IS POSSIBLE THAT 5-HT MAY PLAY,
AT LEAST IN PART, A ROLE AS MEDIATOR OF ADENOSINE-INDUCED BRONCHOCONSTRICTION.
Anno pubblicazione e riferimenti
IMMUNOPHARMACOLOGY. 1992 JAN-FEB;23(1):21-8.
ANNO: 1992 - ISBN:
Titolo
BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA: TRATTAMENTO AMBULATORIALE
Autori
G. GIRBINO M. CAZZOLA
Abstract
Anno pubblicazione e riferimenti
ESI STAMPA MEDICA, 1999 ISBN 88-85675-07-7
ANNO: 1992 - ISBN:
Titolo
INFLUENCE OF SULBACTAM PLUS AMPICILLIN ON THEOPHYLLINE CLEARANCE.
Autori
CAZZOLA M, SANTANGELO G, GUIDETTI E, MATTINA R, CAPUTI M, GIRBINO G.
Abstract
THE EFFECT OF SULBACTAM/AMPICILLIN (500 MG/1000 MG) EVERY 12 HOURS TAKEN FOR SEVEN DAYS
ON THE STEADY-STATE PHARMACOKINETICS OF THEOPHYLLINE WAS STUDIED AMONG 12 PATIENTS
SUFFERING FROM CHRONIC OBSTRUCTIVE PULMONARY DISEASE. THEOPHYLLINE CONCENTRATIONS
WERE MEASURED SERIALLY FOR 12 H BY THE METHOD OF POLARIZED IMMUNOFLUORESCENCE
(ABBOTT TDX SYSTEM). NO INFLUENCE OF SULBACTAM/AMPICILLIN WAS DETECTABLE ON THE
THEOPHYLLINE HALF-LIFE, CLEARANCE OR VOLUME OF DISTRIBUTION. IT WAS CONCLUDED THAT
BOTH DRUGS COULD BE ADMINISTERED CONCOMITANTLY WITHOUT ANY DOSAGE ADJUSTMENT OF
THEOPHYLLINE.
Anno pubblicazione e riferimenti
INT J CLIN PHARMACOL RES. 1991;11(1):11-5.
ANNO: 1991 - ISBN:
Titolo
PNEUMOCONIOSI ED ALTRE MALATTIE PROFESSIONALI DEL POLMONE
Autori
G. GIRBINO
Abstract
Anno pubblicazione e riferimenti
POLMONE IN L. CARRATU’ , E. CATENA C. GRASSI MANUALE DI MALATTIE DELL’APPARATO
RESPIRATORIE MASSON EDITRICE MILANO 221-238 ISBN 88-214-2085-X
ANNO: 1991 - ISBN:
Titolo
A NEW ANTI-INFLAMMATORY--ANALGESIC--ANTIPYRETIC FOR THE TREATMENT OF ACUTE DISEASE OF
THE BRONCHI
Autori
GIRBINO G, OLIANI C, LAURIELLO G, CONDOLUCI M.
Abstract
SIXTY ADULT PATIENTS, 31 MEN AND 29 WOMEN, AGED 44 TO 60, AND AFFECTED BY ACUTE
BRONCHITIS OF PROBABLE BACTERIAL AETIOLOGY WERE RANDOMLY DIVIDED INTO 3 GROUPS OF 20
AND TREATED RESPECTIVELY WITH: 1) MORNIFLUMATE (ONE 700 MG TABLET TWICE A DAY) +
AMOXICILLIN (ONE 1 G TABLET TWICE A DAY); 2) FEPRAZONE (ONE 200 MG TABLET TWICE A DAY) +
AMOXICILLIN (ONE 1 G TABLET TWICE A DAY); 3) AMOXICILLIN (ONE 1 G TABLET TWICE A DAY). MEAN
THERAPY DURATION WAS 9 DAYS. THE ACTION OF THE DRUGS UNDER STUDY WAS ASSESSED BY
OBJECTIVE CHEST EXAMINATION AND BY EVALUATING THE MODIFICATIONS OF COUGH INTENSITY
AND FREQUENCY, CHEST PAIN EXPECTORATING DIFFICULTY, AMOUNT OF EXPECTORATION, BODY
TEMPERATURE. THE OVERALL ASSESSMENTS WERE COMPLETED BY SIDE-EFFECT RECORDING AND
BY LABORATORY EXAMINATIONS CARRIED OUT AT THE BEGINNING AND END OF THE STUDY. CHECKS
WERE MADE REGULARLY ON ADMISSION, AND IN THE 3RD, 5TH, 7TH AND LAST DAY OF THERAPY. THE
ABOVE MENTIONED PARAMETERS SHOWED A QUICKER REGRESSION OF BRONCHIAL INFLAMMATION
IN THE SUBJECTS TREATED ALSO WITH THE ANTIINFLAMMATORY DRUG COMPARED TO THOSE
TREATED ONLY WITH THE ANTIBIOTIC. FURTHERMORE, IN THE SUBJECTS TREATED WITH
MORNIFLUMATE SUCH IMPROVEMENT WAS MORE RAPIDLY ACHIEVED COMPARED TO THOSE WHO
RECEIVED FEPRAZONE. THE ANALGESIC AND ANTIPYRETIC EFFECTS OF MORNIFLUMATE WERE ALSO
REMARKABLE. ALL TESTED DRUGS WERE WELL TOLERATED.