ventricular myocardial function <strong>in</strong> competitive athletes: a Doppler tissue imag<strong>in</strong>g study. Ital Heart J 2002;3:34-40. 23. Sahn DJ, De Maria A, Kisslo J, Weyman A, for The Committee on M-mode Standardization of the American Society of Echocardiography. Recommendations regard<strong>in</strong>g quantitation <strong>in</strong> M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978;58:1072-1083. 24. Devereux RB, Reicheck N. Echocardiographic determ<strong>in</strong>ation of left ventricular mass: anatomic validation of the method. Circulation 1977;55:613-618. 25. de Simone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, de Divitiis O, Alderman MH, Laragh JH.. Left ventricular mass and body size <strong>in</strong> normotensive ch<strong>il</strong>dren and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol 1992;20:1251-1260. 26. Dub<strong>in</strong> J, Wallerson DC, Cody RJ, Devereux RB. Comparative accuracy of Doppler echocardiographic methods for cl<strong>in</strong>ical stroke volume determ<strong>in</strong>ation. Am Heart J 1990;120:116-123. 27. Foale RA, Nihoyannopoulos P, Mc Kenna W. Echocardiographic measurement of normal adult right ventricle. Br Heart J 1986;56:33-44. 28. Kaul S, Tei C, Hopk<strong>in</strong>s JM, Shah PM. Assessment of right ventricular function us<strong>in</strong>g two dimensional echocardiography. Am Heart J 1984;128:301-307. 29. Nishimura RA, Abel MD, Hatle LK, Tajik AJ. Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography (Part II: cl<strong>in</strong>ical studies). Mayo Cl<strong>in</strong> Proc 1989;64:181-204. 30. Colan SD, Sanders SP, Borow KM. Physiological hypertrophy: effects on left ventricular systolic mechanics <strong>in</strong> humans. J Am Coll Cardiol 1987;9:776-783. 31. Colan SD, Sanders SP, Mc Pherson D, Borow KM. Left ventricular diastolic function <strong>in</strong> elite athletes with physiologic cardiac hypertrophy. J Am Coll Cardiol 1985;6:545-549. 32. Raizada V, Sahn DJ, Covell JW. Factors <strong>in</strong>fluenc<strong>in</strong>g late right ventricular ejection. Cardiovasc Res 1988;22:244-248. 33. Myhre ES, Sl<strong>in</strong>ker BK, LeW<strong>in</strong>ter MM. Absence of right ventricular isovolumic relaxation <strong>in</strong> open-chest anaestethized dogs. Am J Physiol 1992;263:587-590. 34. Feneley MP, Olsen CO, Glower DD, Rank<strong>in</strong> JS. Effect of acutely <strong>in</strong>creased right ventricular afterload on work output from the left ventricle <strong>in</strong> conscious dogs. Systolic ventricular <strong>in</strong>teraction. Circ Res 1989;65:135-145. 35. Dell’Italia LJ, Starl<strong>in</strong>g MR, Crawford MH, Boros BL, Chaudhuri TK, O’Rourke RA. Right ventricular <strong>in</strong>farction: identification by hemodynamic measurements before and after volume load<strong>in</strong>g and correlation with non-<strong>in</strong>vasive techniques. J Am Coll Cardiol 1984;4:931-939. 36. Caso P, Galderisi M., Cicala S, Cioppa C, D’Andrea A, Lagioia G, Liccardo B, Mart<strong>in</strong>iello AR, M<strong>in</strong><strong>in</strong>ni N. Association between right ventricular relaxation time and pulmonary arterial pressure <strong>in</strong> chronic obstructive lung disease: analysis by pulsed Doppler Tissue Imag<strong>in</strong>g. J Am Soc Echo 2001;14:970-977. 37. Galderisi M, Benjam<strong>in</strong> EJ, Evans JC, D’Agost<strong>in</strong>o RB, Fuller DL, Lehman B, Levy D. Impact of heart rate and PR <strong>in</strong>terval on Doppler <strong>in</strong>dexes of diastolic f<strong>il</strong>l<strong>in</strong>g <strong>in</strong> an elderly cohort (the Fram<strong>in</strong>gham Heart Study). Am J Cardiol 1993;72:1183-1187. 38. Benjam<strong>in</strong> EJ, Levy D, Anderson KM, Wolf PA, Plehn JH, Evans JC, Comai K, Fuller DL, Sutton MS. Determ<strong>in</strong>ants of Doppler <strong>in</strong>dices of diastolic function <strong>in</strong> normal subjects (The Fram<strong>in</strong>gham Heart Study). Am J Cardiol 1992;70:508-515. 39. Brown CD, Chow E, Farrar DJ. Left ventricular unload<strong>in</strong>g decreases rate of isovolumic right ventricular pressure decl<strong>in</strong>e. Am J Physiol 1993;265:663-669. 40. Patterson SW, Starl<strong>in</strong>g EH. On the mechanical factors which determ<strong>in</strong>e the output of the ventricles. J Physiol 1914;48:357-379. A. D’Andrea et al. Cooperazione biventricolare 49
50 Lo Studio ASCOT-LLA: si aprono nuovi scenari terapeutici nella prevenzione primaria degli eventi cardiovascolari? The ASCOT-LLA Study: new possib<strong>il</strong>ity <strong>in</strong> the treatment <strong>in</strong> patients with multiple cardiovascular risk factors? G. Sch<strong>il</strong>laci I risultati dello Studio ASCOT-LLA, recentemente pubblicati, mostrano i benefici di un trattamento ipocolesterolemizzante con atorvastat<strong>in</strong>a <strong>in</strong> una popolazione di pazienti ipertesi con molteplici fattori di rischio cardiovascolare ma senza storia di cardiopatia ischemica e con valori di colesterolemia normali o solo modestamente aumentati (
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