N. Bresolin - E. Medea

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Le cellule staminali possono avere effetti terapeutici attraverso diversi meccanismi Neuroprotezione Sostituzione cellulare Produzione di molecole con effetto neurotrofico, antiinfiammatorio, vasogenico etc. Geneticamente modificate per produrre specifici fattori Genesi di: •Nuovi neuroni •Glia
SVZ Isolation Astrocytes SVZ MATURE CELLS Neurons Corti et al Cellule staminali neurali Dissociate Oligodendrocytes EGF/FGF-2 SELF-RENEWAL EGF/FGF-2
Page 1 and 2: L’impiego delle cellule staminali
Page 3 and 4: Cellule staminali • Capacità di
Page 5: Blood blood cells Vessels endotheli
Page 8: In vitro differentiation of iPS. In
Page 13 and 14: Multipotentiali Multipotentiality,
Page 15 and 16: Il trapianto di cellule staminali L
Page 17 and 18: Distrofia Muscolare di Duchenne E
Page 19 and 20: Il nostro obiettivo: trapiantare le
Page 21 and 22: Muscle homing of the Sca-1+/CD34-MD
Page 23 and 24: Myogenic differentiation of Sca-1+/
Page 25 and 26: TRAP assay Clonogenic, self-renewal
Page 27 and 28: Double-blinded randomized clinical
Page 29 and 30: Local side effects after intramuscu
Page 31 and 32: Intra-arterial delivery of wild-typ
Page 33 and 34: Expression of α-SG and dystrophin
Page 35 and 36: Three-dimensional visualization of
Page 37 and 38: Lentivirus U7exon51 map : Promoteur
Page 39: Human dystrophin expression in scid
Page 43 and 44: Sclerosi Laterale Amiotrofica
Page 45 and 46: LeX+CX+ cells share the properties
Page 47 and 48: Time to fall (s) 250 200 150 100 50
Page 49 and 50: Il trapianto di cellule LeX+CXCR4+
Page 51 and 52: Cellule staminali nelle malattie de
Page 53 and 54: Atrofia Muscolare Spinale (SMA) SMN
Page 56: Neuroni ALDH proiettano lunghi asso
Page 60 and 61:
GFP/Nestina Predifferenziamento GFP
Page 62 and 63:
Midollo spinale di topo trapiantato
Page 64 and 65:
Effetti del trapianto sui motoneuro
Page 66 and 67:
Utilizzo di sostanze per promuovere
Page 68:
Stem Cell Research Institute DIBIT-
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N. Bresolin - E. Medea

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