EM_Lezione 13.pdf
EM_Lezione 13.pdf
EM_Lezione 13.pdf
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Duplicazione genica: perdita di funzione di una delle copie<br />
Ci sono ~7000 malattie genetiche documentate in letteratura che<br />
testimoniano come una mutazione possa distruggere la funzione di<br />
un gene che codifica per una proteina.<br />
PERO’:<br />
“As long as there are other copies of a gene that function normally, a<br />
duplicate gene may accumulate deleterious mutations and become<br />
nonfunctional without adversely affecting the fitness of the<br />
organism.”<br />
J. B. S. Haldane (1933)<br />
“Because deleterious mutations occur far more often than<br />
advantageous ones, a redundant duplicate gene is more likely to<br />
become nonfunctional than to evolve into a new gene.”<br />
Susumu Ohno (1972)