(.pdf) dr.ssa Antonella Ferro - Progettoeventi
(.pdf) dr.ssa Antonella Ferro - Progettoeventi
(.pdf) dr.ssa Antonella Ferro - Progettoeventi
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Receptor-T-DM1 complex is<br />
internalized into cancer cell<br />
T-DM1: meccanismo d’azione<br />
• Trastuzumab-like activity by binding to HER2<br />
• Targeted intracellular delivery of DM1<br />
T-DM1 binds to the HER2 protein<br />
on cancer cells<br />
Potent antimicrotubule<br />
agent is released once inside<br />
the tumor cell
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