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(.pdf) dr.ssa Antonella Ferro - Progettoeventi

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T-DM1: the first-in-class HER2-targeted<br />

antibody-<strong>dr</strong>ug conjugate<br />

Target expression: HER2<br />

Monoclonal antibody: trastuzumab<br />

Cytotoxic agent: DM1<br />

Highly potent chemotherapy<br />

(maytansine derivative)<br />

Linker<br />

Systemically stable<br />

Breaks down in target cancer cell<br />

T-DM1

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