(.pdf) dr.ssa Antonella Ferro - Progettoeventi
(.pdf) dr.ssa Antonella Ferro - Progettoeventi (.pdf) dr.ssa Antonella Ferro - Progettoeventi
Pertuzumab binds to the dimerisation domain of HER2, prevents HER2 forming dimer pairs and may flag cells for destruction by the immune system angiogenesis RAS Raf MEK MAPK HER2 mTOR Cyclin D1 cell cycle control proliferation p27 BAD NFκB ↓ apoptosis HER3 GSK3β ↑ survival
Trastuzumab and pertuzumab may have synergistic activity Trastuzumab Subdomain IV of HER2 Trastuzumab continually suppresses HER2 activity Flags cells for destruction by the immune system Does not inhibit HER2 dimerisation HER2 receptor Pertuzumab Dimerisation domain of HER2 Pertuzumab inhibits HER2 forming dimer pairs Suppresses multiple HER signalling pathways Flags cells for destruction by the immune system
- Page 1 and 2: Utilizzo dei farmaci nei diversi co
- Page 3 and 4: HER2 positive breast cancer “Targ
- Page 5 and 6: Trastuzumab (Herceptin) • Il Tras
- Page 7 and 8: Trastuzumab binds to ErbB2 on tumou
- Page 9 and 10: Antibody-Dependent Cellular Cytotox
- Page 11 and 12: Potenziale meccanismo di trastuzuma
- Page 13: Malattia adiuvante
- Page 17 and 18: DFS: Sequential (Arm B: AC → T
- Page 19 and 20: Malattia Neo- adiuvante
- Page 21 and 22: Studio NOAH: Event Free Survival ne
- Page 23 and 24: Trastuzumab has transformed the pro
- Page 25 and 26: Definition of resistance In most tu
- Page 27 and 28: Truncated HER2 (p95 HER2 ): clinica
- Page 29 and 30: Trastuzumab Capecitabine von Minckw
- Page 31 and 32: GBG 26/BIG 03-05: main results Cape
- Page 33 and 34: Phase III, randomised, controlled s
- Page 35 and 36: Lapatinib • Binds to intracellula
- Page 37 and 38: Lapatinib may sensitise HER2 positi
- Page 39 and 40: Pertuzumab • Pertuzumab, inibitor
- Page 41 and 42: HER2 dimerization is key to signali
- Page 43: Trastuzumab binds to subdomain IV o
- Page 47 and 48: Receptor-T-DM1 complex is internali
Pertuzumab binds to the dimerisation domain of HER2, prevents<br />
HER2 forming dimer pairs and may flag cells for destruction by the<br />
immune system<br />
angiogenesis<br />
RAS<br />
Raf<br />
MEK<br />
MAPK<br />
HER2<br />
mTOR<br />
Cyclin D1<br />
cell cycle<br />
control<br />
proliferation<br />
p27<br />
BAD<br />
NFκB<br />
↓ apoptosis<br />
HER3<br />
GSK3β<br />
↑ survival
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