(.pdf) dr.ssa Antonella Ferro - Progettoeventi
(.pdf) dr.ssa Antonella Ferro - Progettoeventi
(.pdf) dr.ssa Antonella Ferro - Progettoeventi
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Truncated HER2 (p95 HER2 ): clinical<br />
significance<br />
Extracellular domain<br />
(ECD) released • A constitutively active, truncate form of<br />
HER2, p95HER2, has kinase activity but<br />
lacks the extracellular domain and the<br />
binding site of trastuzumab<br />
Truncated HER2<br />
receptor<br />
(p95 HER2 )<br />
• Truncated p95HER2 is expressed at<br />
high frequency (up to 60%) in HER2overexpressing<br />
breast cancer<br />
Molina et al. Clin Cancer Res 2002;8:347-53; Saez et al. Clin Cancer Res 2006;12:424-31; 3.
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