(.pdf) dr.ssa Antonella Ferro - Progettoeventi

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Potenziali meccanismi di resistenza al trastuzumab • Prevenzione del legame di trastuzumab a HER2 • Inibizione dei meccanismi immuno-mediati • Up-regulation dei signaling pathways downstream di HER2 • Up-regulation di growth factor receptor-signaling pathways alternativi • Recettore p95 troncato
Truncated HER2 (p95 HER2 ): clinical significance Extracellular domain (ECD) released • A constitutively active, truncate form of HER2, p95HER2, has kinase activity but lacks the extracellular domain and the binding site of trastuzumab Truncated HER2 receptor (p95 HER2 ) • Truncated p95HER2 is expressed at high frequency (up to 60%) in HER2overexpressing breast cancer Molina et al. Clin Cancer Res 2002;8:347-53; Saez et al. Clin Cancer Res 2006;12:424-31; 3.
Page 1 and 2: Utilizzo dei farmaci nei diversi co
Page 3 and 4: HER2 positive breast cancer “Targ
Page 5 and 6: Trastuzumab (Herceptin) • Il Tras
Page 7 and 8: Trastuzumab binds to ErbB2 on tumou
Page 9 and 10: Antibody-Dependent Cellular Cytotox
Page 11 and 12: Potenziale meccanismo di trastuzuma
Page 13: Malattia adiuvante
Page 17 and 18: DFS: Sequential (Arm B: AC → T
Page 19 and 20: Malattia Neo- adiuvante
Page 21 and 22: Studio NOAH: Event Free Survival ne
Page 23 and 24: Trastuzumab has transformed the pro
Page 25: Definition of resistance In most tu
Page 29 and 30: Trastuzumab Capecitabine von Minckw
Page 31 and 32: GBG 26/BIG 03-05: main results Cape
Page 33 and 34: Phase III, randomised, controlled s
Page 35 and 36: Lapatinib • Binds to intracellula
Page 37 and 38: Lapatinib may sensitise HER2 positi
Page 39 and 40: Pertuzumab • Pertuzumab, inibitor
Page 41 and 42: HER2 dimerization is key to signali
Page 43 and 44: Trastuzumab binds to subdomain IV o
Page 45 and 46: Trastuzumab and pertuzumab may have
Page 47 and 48: Receptor-T-DM1 complex is internali

(.pdf) dr.ssa Antonella Ferro - Progettoeventi

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