Cristiano Vernesi

SILVIA FUSELLI CV
Personal info
Date of birth: 21/05/1973
Place of birth: Verbania (Italy)
Silvia Fuselli
Curriculum vitae
Mailing address
Laboratory of Population Genetics
Department of Biology and Evolution
University of Ferrara
Via L. Borsari 46
44100 Ferrara, Italy
Phone: +39-0532-455731
e-mail: silvia.fuselli@unife.it

SILVIA FUSELLI CV
Education
- 1998 First degree in Biological Science (5-year curriculum, with emphasis in Molecular Anthropology),
University of Bologna, Italy. Qualification: 110/110 Cum Laude
- PhD Curriculum Genetics and Evolution (2001-2003) at the laboratory of Population Genetics (advisor prof.
Guido Barbujani) of the Department of Biology, University of Ferrara
- Specialisation School: degree in Applied Genetics (2005), University of Bologna
Present position
- Assistant professor, laboratory of Population Genetics, University of Ferrara.
Research experience
- 1997-98 Genetic variation of STRs marker in Central Asian populations, Molecular Anthropology laboratory
(prof. Davide Pettener) of the Department of Biology, University of Bologna
- 1998-99 Role of p75 neurotrophine receptor in apoptotic intracellular program, Molecular Genetics laboratory
(prof. Giuliano Della Valle) of the Department of Biology, University of Bologna
- 2000-01 Mitochondrial DNA Diversity in Andean populations, Molecular Anthropology laboratory,
Department of Biology, University of Bologna
- August-October 2002 Development of new high-throughput methodology for CYP2D6 genotyping as a part of
a population and evolution collaborative project between the Molecular Population Genetics laboratory
of the University of Ferrara and the Laboratory of Forensic Biology of the University of Helsinki.
Laboratory of Forensic Biology (prof. Antti Sajantila), Department of Forensic Medicine, University of
Helsinki
-PhD project (2001-2003): Investigation of genetic diversity and evolution at a locus involved in drug
metabolism, CYP2D6, in human populations from Europe.
-2004-2005 post-doc, Laboratory of Forensic Biology, Department of Forensic Medicine, University of Helsinki.
(prof. Antti Sajantila). Projects: Pharmacogenetics, population genetics and evolution of drug
metabolising enzymes.
-January-November 2006 post-doc, laboratory of Population Genetics (Prof. Guido Barbujani), University of
Ferrara. Project: The role of pharmacogenetics in prediction of anti-cholinesterase treatment in Alzheimer’s
patients
Teaching Experience
- 2004 Biological Databases and Bioinformatics, University of Ferrara
-2006-2010: Evolution and Genetics, University of Ferrara
-2006: “The origin of life and genome evolution”, as a part of Genomics, University of Ferrara
-2009: Genomics, University of Ferrara
-2010: Molecular evolution, University of Ferrara

SILVIA FUSELLI CV
Research interests
- Demographic history of South American native populations and genetic bases of human adaptation to high
altitude
(collaboration with professor Eduardo Tarazona-Santos, Departamento de Biologia, Universitade Federal de
Minas Gerais, Brazil, Robert H Gilman, Department of International Health, Bloomberg School of Public
Health, Johns Hopkins University, Bethesda, MD, USA; and Rosa Pacheco, National University of San Antonio
Abad in Cuzco)
- Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at
CYP2D6
(collaboration with professor Antti Sajantila, Laboratory of Forensic Biology, University of Helsinki, Finland;
collaboration with Guido Barbujani, University of Ferrara, Italy)
- The role of pharmacogenetics in prediction of anti-cholinesterase treatment in Alzheimer’s patients
(collaboration with Sez. di Neurologia, Dipartimento di Neuroscienze, Azienda Ospedale-Università S. Anna,
Ferrara)
Invited speaker: Courses and Workshops
European School of genetic Medicine, 4th Course in Statistical Genetic Analysis of Complex Phenotypes.
Bertinoro di Romagna, 21-24 June 2008. Invited speaker: “Population genetics”
PORTUGALIÆ GENETICA 10th. Edition 22-24 March 2007, University of Porto, Portugal, IPATIMUP.
Invited speaker: “Diversity and evolution at loci of pharmacogenetic interest”
“Human Population Genetics and Genetic Epidemiology” November, 15-19, 2004, Università di Roma La
Sapienza, Roma. A course by Dr Eduardo Tarazona-Santos. Invited speaker
Publications
-Fuselli S, de Filippo C, Mona S, Sistonen J, Fariselli P, Destro-Bisol G, Barbujani G, Bertorelle G, Sajantila A.
Evolution of Detoxifying Systems: the Role of Environment and Population History in Shaping Genetic
Diversity at Human CYP2D6 Locus. Pharmacogenetics and genomics, in press
- Sistonen J, Fuselli S, Palo J, Chauhan N, Padh N, Sajantila A. (2009) Pharmacogenetic variation at CYP2C9,
CYP2C19, and CYP2D6 at global and micro-geographic scales. Pharmacogenetics and genomics,
Pharmacogenet Genomics. 19(2):170-9.
- Besaggio D*, Fuselli S*, Srikummool M, Kampuansai J, Castrì L, Tyler-Smith C, Seielstad M, Kangwanpong
D, Bertorelle G. (2007) Genetic variation in Northern Thailand Hill Tribes: origins and relationships with social
structure and linguistic differences. BMC Evol Biol. 16;7 Suppl 2:S12. *equal contribution
- Tarazona-Santos E, Raimondi S, Fuselli S. Chapter 2: Controlling the effects of population stratification by
admixture in pharmacogenetics. In: Guilherme Suarez-Kurtz. (Org.). Pharmacogenomics in Admixed
populations. Austin, TX: Landes Bioscience, 2007, v. , p. 12-27.

SILVIA FUSELLI CV
- Cruciani F, La Fratta R, Trombetta B, Santolamazza P, Sellitto D, Colomb EB, Dugoujon JM, Crivellaro F,
Benincasa T, Pascone R, Moral P, Watson E, Melegh B, Barbujani G, Fuselli S, Vona G, Zagradisnik B, Assum
G, Brdicka R, Kozlov AI, Efremov GD, Coppa A, Novelletto A, Scozzari R. (2007) Tracing Past Human Male
Movements in Northern/Eastern Africa and Western Eurasia: New Clues from Y-chromosomal Haplogroups
E-M78 and J-M12. Mol Biol Evol. 24(6):1300-11.
- Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S. (2007) CYP2D6 worldwide genetic variation
shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 17(2):
93-101.
- Fuselli S, Gilman RH, Chanock SJ, Bonatto SL , De Stefano G , Evans CA, Labuda D, Luiselli D, Salzano
FM, Soto G , Vallejo G, Sajantila A, Pettener D, Tarazona-Santos E. (2007) Analysis of nucleotide diversity of
NAT2 coding region reveals homogeneity across Native American populations and high intra-populations
diversity. Pharmacogenomics J. 7(2):144-52.
- Sistonen J, Fuselli S, Levo A, Sajantila A. (2005) CYP2D6 genotyping by a multiplex primer extension
reaction. Clin Chem. 51(7):1291-5.
- Fuselli S, Dupanloup I, Frigato E, Cruciani F, Scozzari R, Moral P, Sistonen J, Sajantila A, Barbujani G. (2004)
Molecular Diversity at the CYP2D6 Locus in the Mediterranean Region. Eur J Hum Genet. 12(11):916-24.
-Fuselli S, Tarazona-Santos E, Dupanloup I, Soto A, Luiselli D, Pettener D (2003) Mitochondrial DNA
Diversity In South America And The Genetic History Of Andean Highlanders. Mol Biol Evol 20(10):1682-1691.
-Vernesi C, Fuselli S, Castrì L, Bertorelle G, Barbujani G (2002) Mitochondrial Diversity in Linguistic Isolates
of the Alps: A Reappraisal. Human Biology. 74 (5): 725-730.
Tutoring
AA 2006-2007
- Laurea Specialistica in Scienze Biomolecolari e Cellulari: Caterina Chianella (titolo della tesi: Basi genetiche della
risposta variabile al trattamento con tre farmaci per il morbo di Alzheimer)
- Laurea triennale in Scienze Biologiche: Pierpaolo Maisano (titolo della tesi: Effetto della stratificazione per età
sull'associazione tra genotipo al locus BCHE e la risposta ai farmaci anticolinesterasici per il morbo di
Alzheimer).
- Laurea triennale in Scienze Biologiche: Sonia Toniolo (titolo della tesi: Il locus ApoE come esempio di
modificatore in uno studio farmacogenetico condotto su pazienti affetti dal morbo di Alzheimer)
- Laurea triennale in Scienze Biologiche: Fabiana Oliveti (titolo della tesi: Sintesi di dati disponibili in letteratura
in un database di informazioni genotipiche e fenotipiche di interesse farmacogenetico)
- Laurea triennale in Scienze Biologiche: Sara Testoni (titolo della tesi: Descrizione della variabilità genetica a loci
codificanti enzimi della fase I del metabolismo dei farmaci e conseguente predizione della risposta terapeutica
in gruppi umani rappresentativi di diverse aree geografiche mondiali)
AA 2007-2008
- Laurea triennale in Scienze Biologiche: Letizia Ma rullo (titolo della tesi: La variabilità genetica al locus ApoE e
la risposta alla terapia farmacologia in pazienti affetti dal morbo di Alzheimer)

SILVIA FUSELLI CV
- Laurea triennale in Scienze Biologiche: Carmen Corciulo (titolo della tesi: Studio dell'evoluzione molecolare del
gene CYP2D6 in popolazioni di diversa origine geografica con particolare riferimento ai processi selettivi)
AA 2008-2009
- Laurea Specialistica in Scienze Biomolecolari e Cellulari: Pierpaolo Maisano (titolo della tesi: Studio della
variabilità genetica per ricostruire scenari demografici ed adattativi in popolazioni native delle Ande peruviane)
- Laurea triennale in Scienze Biologiche: Giampaolo Morciano (titolo della tesi: Studio della variabilità genetica
del gene EPO in popolazioni umane di alta quota delle Ande peruviane)