Cristiano Vernesi
Cristiano Vernesi
Cristiano Vernesi
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SILVIA FUSELLI CV<br />
Personal info<br />
Date of birth: 21/05/1973<br />
Place of birth: Verbania (Italy)<br />
Silvia Fuselli<br />
Curriculum vitae<br />
Mailing address<br />
Laboratory of Population Genetics<br />
Department of Biology and Evolution<br />
University of Ferrara<br />
Via L. Borsari 46<br />
44100 Ferrara, Italy<br />
Phone: +39-0532-455731<br />
e-mail: silvia.fuselli@unife.it
SILVIA FUSELLI CV<br />
Education<br />
- 1998 First degree in Biological Science (5-year curriculum, with emphasis in Molecular Anthropology),<br />
University of Bologna, Italy. Qualification: 110/110 Cum Laude<br />
- PhD Curriculum Genetics and Evolution (2001-2003) at the laboratory of Population Genetics (advisor prof.<br />
Guido Barbujani) of the Department of Biology, University of Ferrara<br />
- Specialisation School: degree in Applied Genetics (2005), University of Bologna<br />
Present position<br />
- Assistant professor, laboratory of Population Genetics, University of Ferrara.<br />
Research experience<br />
- 1997-98 Genetic variation of STRs marker in Central Asian populations, Molecular Anthropology laboratory<br />
(prof. Davide Pettener) of the Department of Biology, University of Bologna<br />
- 1998-99 Role of p75 neurotrophine receptor in apoptotic intracellular program, Molecular Genetics laboratory<br />
(prof. Giuliano Della Valle) of the Department of Biology, University of Bologna<br />
- 2000-01 Mitochondrial DNA Diversity in Andean populations, Molecular Anthropology laboratory,<br />
Department of Biology, University of Bologna<br />
- August-October 2002 Development of new high-throughput methodology for CYP2D6 genotyping as a part of<br />
a population and evolution collaborative project between the Molecular Population Genetics laboratory<br />
of the University of Ferrara and the Laboratory of Forensic Biology of the University of Helsinki.<br />
Laboratory of Forensic Biology (prof. Antti Sajantila), Department of Forensic Medicine, University of<br />
Helsinki<br />
-PhD project (2001-2003): Investigation of genetic diversity and evolution at a locus involved in drug<br />
metabolism, CYP2D6, in human populations from Europe.<br />
-2004-2005 post-doc, Laboratory of Forensic Biology, Department of Forensic Medicine, University of Helsinki.<br />
(prof. Antti Sajantila). Projects: Pharmacogenetics, population genetics and evolution of drug<br />
metabolising enzymes.<br />
-January-November 2006 post-doc, laboratory of Population Genetics (Prof. Guido Barbujani), University of<br />
Ferrara. Project: The role of pharmacogenetics in prediction of anti-cholinesterase treatment in Alzheimer’s<br />
patients<br />
Teaching Experience<br />
- 2004 Biological Databases and Bioinformatics, University of Ferrara<br />
-2006-2010: Evolution and Genetics, University of Ferrara<br />
-2006: “The origin of life and genome evolution”, as a part of Genomics, University of Ferrara<br />
-2009: Genomics, University of Ferrara<br />
-2010: Molecular evolution, University of Ferrara
SILVIA FUSELLI CV<br />
Research interests<br />
- Demographic history of South American native populations and genetic bases of human adaptation to high<br />
altitude<br />
(collaboration with professor Eduardo Tarazona-Santos, Departamento de Biologia, Universitade Federal de<br />
Minas Gerais, Brazil, Robert H Gilman, Department of International Health, Bloomberg School of Public<br />
Health, Johns Hopkins University, Bethesda, MD, USA; and Rosa Pacheco, National University of San Antonio<br />
Abad in Cuzco)<br />
- Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at<br />
CYP2D6<br />
(collaboration with professor Antti Sajantila, Laboratory of Forensic Biology, University of Helsinki, Finland;<br />
collaboration with Guido Barbujani, University of Ferrara, Italy)<br />
- The role of pharmacogenetics in prediction of anti-cholinesterase treatment in Alzheimer’s patients<br />
(collaboration with Sez. di Neurologia, Dipartimento di Neuroscienze, Azienda Ospedale-Università S. Anna,<br />
Ferrara)<br />
Invited speaker: Courses and Workshops<br />
European School of genetic Medicine, 4th Course in Statistical Genetic Analysis of Complex Phenotypes.<br />
Bertinoro di Romagna, 21-24 June 2008. Invited speaker: “Population genetics”<br />
PORTUGALIÆ GENETICA 10th. Edition 22-24 March 2007, University of Porto, Portugal, IPATIMUP.<br />
Invited speaker: “Diversity and evolution at loci of pharmacogenetic interest”<br />
“Human Population Genetics and Genetic Epidemiology” November, 15-19, 2004, Università di Roma La<br />
Sapienza, Roma. A course by Dr Eduardo Tarazona-Santos. Invited speaker<br />
Publications<br />
-Fuselli S, de Filippo C, Mona S, Sistonen J, Fariselli P, Destro-Bisol G, Barbujani G, Bertorelle G, Sajantila A.<br />
Evolution of Detoxifying Systems: the Role of Environment and Population History in Shaping Genetic<br />
Diversity at Human CYP2D6 Locus. Pharmacogenetics and genomics, in press<br />
- Sistonen J, Fuselli S, Palo J, Chauhan N, Padh N, Sajantila A. (2009) Pharmacogenetic variation at CYP2C9,<br />
CYP2C19, and CYP2D6 at global and micro-geographic scales. Pharmacogenetics and genomics,<br />
Pharmacogenet Genomics. 19(2):170-9.<br />
- Besaggio D*, Fuselli S*, Srikummool M, Kampuansai J, Castrì L, Tyler-Smith C, Seielstad M, Kangwanpong<br />
D, Bertorelle G. (2007) Genetic variation in Northern Thailand Hill Tribes: origins and relationships with social<br />
structure and linguistic differences. BMC Evol Biol. 16;7 Suppl 2:S12. *equal contribution<br />
- Tarazona-Santos E, Raimondi S, Fuselli S. Chapter 2: Controlling the effects of population stratification by<br />
admixture in pharmacogenetics. In: Guilherme Suarez-Kurtz. (Org.). Pharmacogenomics in Admixed<br />
populations. Austin, TX: Landes Bioscience, 2007, v. , p. 12-27.
SILVIA FUSELLI CV<br />
- Cruciani F, La Fratta R, Trombetta B, Santolamazza P, Sellitto D, Colomb EB, Dugoujon JM, Crivellaro F,<br />
Benincasa T, Pascone R, Moral P, Watson E, Melegh B, Barbujani G, Fuselli S, Vona G, Zagradisnik B, Assum<br />
G, Brdicka R, Kozlov AI, Efremov GD, Coppa A, Novelletto A, Scozzari R. (2007) Tracing Past Human Male<br />
Movements in Northern/Eastern Africa and Western Eurasia: New Clues from Y-chromosomal Haplogroups<br />
E-M78 and J-M12. Mol Biol Evol. 24(6):1300-11.<br />
- Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S. (2007) CYP2D6 worldwide genetic variation<br />
shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 17(2):<br />
93-101.<br />
- Fuselli S, Gilman RH, Chanock SJ, Bonatto SL , De Stefano G , Evans CA, Labuda D, Luiselli D, Salzano<br />
FM, Soto G , Vallejo G, Sajantila A, Pettener D, Tarazona-Santos E. (2007) Analysis of nucleotide diversity of<br />
NAT2 coding region reveals homogeneity across Native American populations and high intra-populations<br />
diversity. Pharmacogenomics J. 7(2):144-52.<br />
- Sistonen J, Fuselli S, Levo A, Sajantila A. (2005) CYP2D6 genotyping by a multiplex primer extension<br />
reaction. Clin Chem. 51(7):1291-5.<br />
- Fuselli S, Dupanloup I, Frigato E, Cruciani F, Scozzari R, Moral P, Sistonen J, Sajantila A, Barbujani G. (2004)<br />
Molecular Diversity at the CYP2D6 Locus in the Mediterranean Region. Eur J Hum Genet. 12(11):916-24.<br />
-Fuselli S, Tarazona-Santos E, Dupanloup I, Soto A, Luiselli D, Pettener D (2003) Mitochondrial DNA<br />
Diversity In South America And The Genetic History Of Andean Highlanders. Mol Biol Evol 20(10):1682-1691.<br />
-<strong>Vernesi</strong> C, Fuselli S, Castrì L, Bertorelle G, Barbujani G (2002) Mitochondrial Diversity in Linguistic Isolates<br />
of the Alps: A Reappraisal. Human Biology. 74 (5): 725-730.<br />
Tutoring<br />
AA 2006-2007<br />
- Laurea Specialistica in Scienze Biomolecolari e Cellulari: Caterina Chianella (titolo della tesi: Basi genetiche della<br />
risposta variabile al trattamento con tre farmaci per il morbo di Alzheimer)<br />
- Laurea triennale in Scienze Biologiche: Pierpaolo Maisano (titolo della tesi: Effetto della stratificazione per età<br />
sull'associazione tra genotipo al locus BCHE e la risposta ai farmaci anticolinesterasici per il morbo di<br />
Alzheimer).<br />
- Laurea triennale in Scienze Biologiche: Sonia Toniolo (titolo della tesi: Il locus ApoE come esempio di<br />
modificatore in uno studio farmacogenetico condotto su pazienti affetti dal morbo di Alzheimer)<br />
- Laurea triennale in Scienze Biologiche: Fabiana Oliveti (titolo della tesi: Sintesi di dati disponibili in letteratura<br />
in un database di informazioni genotipiche e fenotipiche di interesse farmacogenetico)<br />
- Laurea triennale in Scienze Biologiche: Sara Testoni (titolo della tesi: Descrizione della variabilità genetica a loci<br />
codificanti enzimi della fase I del metabolismo dei farmaci e conseguente predizione della risposta terapeutica<br />
in gruppi umani rappresentativi di diverse aree geografiche mondiali)<br />
AA 2007-2008<br />
- Laurea triennale in Scienze Biologiche: Letizia Ma rullo (titolo della tesi: La variabilità genetica al locus ApoE e<br />
la risposta alla terapia farmacologia in pazienti affetti dal morbo di Alzheimer)
SILVIA FUSELLI CV<br />
- Laurea triennale in Scienze Biologiche: Carmen Corciulo (titolo della tesi: Studio dell'evoluzione molecolare del<br />
gene CYP2D6 in popolazioni di diversa origine geografica con particolare riferimento ai processi selettivi)<br />
AA 2008-2009<br />
- Laurea Specialistica in Scienze Biomolecolari e Cellulari: Pierpaolo Maisano (titolo della tesi: Studio della<br />
variabilità genetica per ricostruire scenari demografici ed adattativi in popolazioni native delle Ande peruviane)<br />
- Laurea triennale in Scienze Biologiche: Giampaolo Morciano (titolo della tesi: Studio della variabilità genetica<br />
del gene EPO in popolazioni umane di alta quota delle Ande peruviane)