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Percorsi Assistenziali Neonatologici Anno 2008<br />

29<br />

• Antagonisti dei recettori-H2: Ran<strong>it</strong>idina<br />

Posologia<br />

Per os 2 mg/kg/dose ogni 8 ore (max 12 mg/kg/die)<br />

Ev Bolo EG > 36 settimane 1,5 mg/kg/dose ogni 8 ore<br />

EG < 36 settimane 0,5 mg/kg/dose ogni 12 ore<br />

Ev Continua EG > 36 settimane 0,2 mg/kg/h<br />

EG < 36 settimane 0,06 mg/kg/h<br />

Ridurre la posologia in caso di insufficienza epatica o renale<br />

In previsione di sospensione ridurre il dosaggio del 30% ogni giorno per<br />

ev<strong>it</strong>are iperacid<strong>it</strong>à reattiva<br />

• Inib<strong>it</strong>ori della pompa protonica: Omeprazolo<br />

0,7-3,3 mg/kg /die in 1-2 dosi, 30 minuti prima del pasto<br />

1. Guidelines for Evaluation and treatmen of gastroesophageal reflux in children Recommendations of the North American<br />

Society for pediatric gastroenterology and nutr<strong>it</strong>ion JPGN 2001; vol31 suppl 2<br />

2. Milocco C, Salvatore CM, Torre G et al. Sonography versus continous 24 hours esophageal pHmon<strong>it</strong>oring in the diagnosis of<br />

infant gastroesophageal reflux. Pediatr Med Chir 1997; 19:245-246<br />

3. Aggett PJ, Aposton C, Goulet O et al. Antireflux or antiregurg<strong>it</strong>ation milk products for infants and young children: a<br />

commentary by the ESPGHAN comm<strong>it</strong>tee onf nutr<strong>it</strong>ion. J Pediatr Gastroenterol Nutr 2002;34:496-8<br />

4. Klinkenberg-Knol EC, Nelis F, Dent J et al. Long-term omeprazole treatment in resistant gastroesophageal ferlux disease:<br />

efficacy, safety and influence on gastric mucosa. Gastroenterology 2000;118:661-9<br />

5. Franco MT, Salvia G, Terrin G, Spadaro R, De Rosa I, Iula VD, Cucchiara S. Lansoprazole in the treatment of gastrooesophageal<br />

reflux disease in childhood. Dig Liver Dis 2000;32:660-6<br />

269<br />

Vari

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