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Infettivologici<br />

Percorsi Assistenziali Neonatologici Anno 2008<br />

Piperacillina<br />

EG < 36 settimane: 75 mg/kg ogni 12 ore in 1ª settimana<br />

75 mg/kg ogni 8 ore dopo la 1ª settimana<br />

EG > 36 settimane: 75 mg/kg ogni 8 ore in 1ª settimana<br />

75 mg/kg ogni 6 ore dopo la 1ª settimana<br />

Piperacillina + Tazobactam<br />

Teicoplanina<br />

164<br />

100 mg/kg ogni 12 ore<br />

bolo di 15 mg/kg<br />

mantenimento di 8 mg/kg ogni 24 h (ev o im)<br />

Tobramicina<br />

EG < 28 settimane: 3,5–5 mg/kg in bolo, poi , dopo 24 ore dal bolo,<br />

2,5 mg/kg ogni 24 ore per tutto il primo mese<br />

EG > 28 settimane:<br />

3,5–5 mg/kg in bolo, poi, dopo 12 ore dal bolo,<br />

2,5 mg/kg ogni 12 ore, in 1ª settimana<br />

3,5–5 mg/kg in bolo, poi, dopo 8 ore dal bolo,<br />

2,5 mg/kg ogni 8 ore, dopo la 1ª settimana<br />

Vancomicina<br />

EG < 28 settimane: 15 mg/kg ogni 24 ore<br />

EG 29-35 settimane: 15 mg/kg ogni 12 ore<br />

EG > 35 settimane: 15 mg/kg ogni 8 ore<br />

19<br />

1. Schelonka RL, FreiJ BJ, McCrachen Jr GH. Bacterial and fungal infections. In: MacDonald MG, Mullett MD, Seshia MMK eds.<br />

Avery’s Neonatology. Pathophysiology & management of the newborn. 8th ed<strong>it</strong>ion. Lippincott Williams & Wilkins Co, 2005;<br />

pagg. 1235-1273.<br />

2. Polin RL, Parravicini E, Regan JA, Taeusch HW. Bacterial sepsis and mening<strong>it</strong>is. In: Taeusch HW, Ballard RA, Gleason CA<br />

eds. Avery’s disease of the newborn. 8 th ed<strong>it</strong>ion. Elsevier saunders Co, 2005; pagg. 551-577.<br />

3. U K Mishra, S E Jacobs, L W Doyle and S M Garland. Newer approaches to the diagnosis of early onset neonatal sepsis. Arch.<br />

Dis. Child. Fetal Neonatal Ed. 2006;91;208-212<br />

4. Ng PC. Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed 2004;89: F229–F235.<br />

5. Turner D, Hammerman C, Rudensky B, Schlesinger Y, Schimmel MS. The role of procalc<strong>it</strong>onin as a predictor of nosocomial<br />

sepsis in preterm infants. Acta Pædiatrica, 2006; 95: 1571_1576<br />

6. Mt<strong>it</strong>imila EI, Cooke RWI. Antibiotic regimens for suspected early neonatal sepsis. The Cochrane Library, Issue 4, 2004<br />

7. Gordon A, Jeffery HE. Antibiotic regimens for suspected late onset sepsis in newborn infants. The Cochrane Library, Issue3,<br />

2005

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