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Percorsi Assistenziali Neonatologici Anno 2008<br />

Si consiglia la sost<strong>it</strong>uzione delle pirimetamina e della sulfadiazina con az<strong>it</strong>romicina se:<br />

PLT < 90.000/mmc<br />

Globuli bianchi < 4000/mmc<br />

Neutrofili < 500/mmc<br />

Hb < 9 g/dl<br />

Albuminuria, glicosuria<br />

In caso di corioretin<strong>it</strong>e attiva è necessario effettuare terapia con prednisone 1-1,5<br />

mg/kg/die per 3-4 settimane.<br />

Follow-up del neonato di madre con infezione certa in gravidanza<br />

18<br />

CONTROLLO TIMING<br />

Clinico 1°, 2°, 3°, 6°, 12° e 24° mese<br />

Dosaggio Ig 1°, 2°, 3°, 6° mese<br />

Ecografia cerebrale Nasc<strong>it</strong>a, 1°, 2°, 3° mese<br />

Oculistico<br />

Nasc<strong>it</strong>a, 3°, 6°, 9°, 12°, 18°, 24°<br />

mese, poi al 3°, 4°, 5°, 6° anno<br />

Neurologico 3°, 6°, 9°, 12°, 24° mese<br />

Audiologico tra 4 e 7 mesi<br />

TC e/o EEG Solo se c’è interessamento del SNC<br />

1. Hill D et al. Toxoplasma G.: transmission, diagnosis and prevention. Clin. Microbiol Infect 2002;8:634-640<br />

2. Mombrò M et al. Congen<strong>it</strong>al toxoplasmosis: assessment of risk to newborns in confirmed and uncertain maternal infection. Eur<br />

J Pediatr 2003;162:703-706<br />

3. Remington JS et al. Recent developments for diagnosis of toxoplasmosis. J. Clin Microbiol 2004;42:941-945<br />

4. Jones JL et al. Toxoplasma Gondii infection in the USA: sero prevalence and risk factors. Am J Epidemiol 2001;154:357-365<br />

5. Gilbert E et al. Effect of prenatal treatment on mother to child transmission of Toxoplasma Gondii: retrospective cohort study<br />

of 554 mother-child pairs in Lyon. France. Int J Epidemiol 2001;30:1303-1308<br />

6. American Academy of Pediatrcs. Red Book (VI edizione <strong>it</strong>aliana) 2006, pagg. 520-526<br />

7. Remington JS, KleinJO. Infectious diseases of the fetus and newborn infant. 6 th ed., 2006; pagg 403-464<br />

157<br />

Infettivologici

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