Special topic: Metagenomics - Genome Sciences

Extreme Assembly of U
The analyses describe
organisms with repres
genomes were readily
other abundant but u
provide valuable physio
that could eventually
organisms, help elucida
ity, and allow similar an
such as those performe
assembly efforts and the
that there is consider
variation among related
to disrupt whole-genom
assembly approach that
this approach ‘‘extreme
ods). This approach cu
pairing data and, the
scaffolded sequences. U
as 900 kb could be alig
marinus MIT9312 and P
2J–2L). Consistent pat
below) generally provi
contigs belonging to
Accordingly, large con
were used to investigat
structure, as described
assemblies demonstrab
assembly artifacts, inclu
sequences (Figure 6).
assembly was employed
Yooseph et al., 2007