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K2.7. Sweni, Shah Gen.Med. V.I. BelklinikaMANNOSE- BINDING LECTIN (MBL) LEVELS IN DIABETIC PATIENTSAND ITS ASSOCIATIONS.Mannose- binding lectin (MBL), an acute phase reactant protein activates the“lectin” pathway of complement system independent of the antibodies and playsan important role in the innate immunity. According to the literature it’s level isassociated with the development of diabetic nephropathy. MBL may beinvolved in the pathogenesis of micro- and macrovascular (coronary artery)complications and MBL levels may be used as a prognostic marker for thesecomplications. There is no data regarding the association of MBL level andcarotid artery intima media thickness (IMT).To analyze a correlation betweenserum MBL levels and diabetes and relate it with other parameters such as lipidprofile, HbA1c levels and IMT. Serum MBL levels were measured in a total of42 diabetic patients who had diabetes for more than 10 years (34 type 2 and 8type 1), using a sandwich ELISA technique, using anti- MBL antibodies. 22males and 20 females participated in the study, out of whom 9 were smokersand 33 hypertensives. Parameters such as body mass index (BMI), serumglucose levels, Hemoglobin A1c (HbA1c), lipid profile and urinary albuminexcretion were measured. Mean age and their BMI (kg/m2) were 54 years and31. 48 and 52% patients were males and females respectively. The mean MBLlevel was 1157ng/l, ranging from 18 to 13550ng/l and there was no significantdifference between Type 1 and Type 2 diabetics. The average blood glucose andHbA1c levels were 11mmol/l and 8%. Mean urinary albumin excretion was146mg/day. No significant correlation was found between MBL level of thesample population and serum glucose, HbA1c, total cholesterol, LDL, HDL,triglyceride (Tg), BMI, duration of diabetes and IMT. In type 1 diabetics therewas a borderline correlation between MBL and Tg levels (p=0.06), while intype 2 between MBL and HbA1c levels (p=0.07). MBL levels were independentof smoking habit and hypertension. No association was found between MBLlevel and IMT. The borderline association with HbA1c and Tg level may predictit’s role in macrovascular complications but it needs more observation.Currently we are in the process of analyzing the MBL levels of more patients.Témavezet: Dr. Káplár Miklós, Dr. Papp Mária197