Folia Anthropologica 11; 51−53. (2012) FOUR CIRCADIAN AND TWO CIRCASEMIDIAN PERIODS IN SLEEP-WAKEFULNESS OF A MAN ON A SELF- SELECTED ROUTINE * John F. Costella 1 , Franz Halberg 2 , Dewayne Hillman 2 , Miroslav Mikulecky 3 , Germaine Cornélissen 2 1 Peter MacCallum Cancer Centre, Melbourne, Australia 2 Halberg Chronobiology Center, University of Minnesota, Minneapolis, USA 3 Bratislava, Slovakia A free-running experiment (COSTELLA) is based on an hourly record of sleeping and waking by JFC (1990.02.19 to 1993.03.11, 1117 days). The original spectrum reveals a dominating 2-peaked about 12-hour (h) component, the slightly longer period, τ, of the second peak perhaps corresponding to a tidal τ. The peak at 24 h was also accompanied by a second smaller peak, perhaps corresponding to a double tidal τ, Figure 1. Figure 1. Fourier power spectral density of a clinically healthy man (JFC) on a self-selected sleepwake schedule A double tidal 24.8-h (lunar) τ and another 24-h synchronized τ, were both present and alternated in prominence in a 61-year-old woman, JF, with a 20-year history of twice-yearly, 2-3 months, adynamic depression, during which the 24.8-h τ predominated while the 24-h synchronized τ had the * Based on the paper read at the International Congress “Natural Cataclysms and Global Problems of the Modern Civilization”. Istanbul, 19–21 September, 2011. 51
larger amplitude, A, during relative well-being (HALBERG et al. 2010). As Table 1 shows, multiple τs also characterize a clinically healthy man, JFC, 23 years of age at start of recording. Coexisting with a 24-h synchronized and a 24.8-h lunar τ are the presence of a 24.26-h τ that may correspond to a free-running τ (DUFFY et al. 2011, SMITH et al. 2009), and a 24.4-h τ corresponding to perhaps a nearly equal pull by society and by the moon. Chronobiologic serial sections in Figures 1 and 2 with the fit of 24.00-h and 24.80-h τs to intervals covering 7 cycles (of the τ fitted) document the net result of the relative contributions and changing prominence of societal (socidian), lunidian and other τs. Table 1 also shows that the As of 24.00 and 24.84-h τs by far exceed the amplitudes of a possibly freerunning τ or of an intermediate (compromise?) component resulting from similar pulls by society and the moon. By contrast to Figure 1, the half-day τ's amplitude is much smaller than that of the day. Multiple circadian periods, as such, in sleep-wakefulness on a self-selected routine need not be pathogenetic, at least not in a single well-documented case. Nonlinear analyses of consecutive sections of time series validate the presence of both an about 24.8- and 24.0-h period. While JF consistently demonstrated 2 periods, JFC demonstrates, in different sections of time series, at least 3 circadian periods and often their 2 harmonics. Period (CI*) Amplitude (CI) Acrophase (CI) Name Length (h) Solar day 24.001 (24.000, 24.001) 0.25443 (0.2337, 0.2751) -293˚ (-288, -287) Lunar day 24.836 (24.833, 24.838) 0.10606 (0.0854, 0.1268) -233˚ (-222, -244) Compromise ? 24.432 (24.427, 24.436) 0.05643 (0.0357, 0.0772) -250˚ (-229, -271) Free-running ? 24.260 (24.252, 24.268) 0.03253 (0.0118, 0.0533) -10˚ (-334, -47) Half-day 11.999 (11.997, 12.001) 0.03204 (0.0113, 0.0527) -356˚ (-319, -33) Tide 12.414 (12.410, 12.418) 0.01728 (0.0034, 0.0380) -199˚ (-131, -268) *With uncertainties (CI, 95% confidence interval) **A healthy man, 23 years of age at start of recording from February 19, 1990, to March 11, 1993 with linearnonlinear rhythmometry by the extended cosinor. Local analyses by separate serial sections with 24.0- and 24.8- h periods (in 1-week intervals) reveal the dominance, in alternation, of these 2 periods in the data. Table 1. Periods, amplitudes and acrophases* found in sleep-wakefulness on a largely self-selected schedule by JC** References COSTELLA, J. F.: A free-running experiment. assassinationscience.com/johncostella/sleep/bom-weather-data. zip DUFFY, J. F.–CAIN, S. W.–CHANG, A. M.–PHILLIPS, A. J. K.–MUENCH, M. Y.–GRONFIER, C.– WYATT, J. K.–DIJK, D-J.–WRIGHT, K. P. JR.–CZEISLER, C. A. (2011): Sex difference in the near 24- hour intrinsic period of the human circadian timing system. PNAS Early Edition. www.pnas.org/cgi/doi10.1073 /pnas.1010666108 HALBERG, F.–CORNÉLISSEN, G.–CEGIELSKI, N.–HILLMAN, D.–HALBERG FRANCINE– SCHWARTZKOPF, O.–MCCRATY, R.–FINLEY, J.–THOMAS, F.–KINO, T.–CHROUSOS, G.– SONKOWSKY, R. P.–EL-KHOURY, M.–ILYIA, E. (2010): Circadian dysfrequentia of cortisol, melatonin, DHEA, testosterone and estradiol. In: Halberg F, Kenner T, Fiser B, Siegelova J, (eds.): Noninvasive Methods in Cardiology, September 16-17, 2010, Brno, Czech Republic. Brno: Faculty of Medicine, Masaryk University. 9–22. SMITH, M. R.–BURGESS, H. J.–FOGG, L. F.–EASTMAN, C. I. (2009): Racial differences in the human endogenous circadian period. PLoS One: 4 (6): e6014. doi:10.1371/journal.pone.0006014 52
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