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JOURNAL ASMAC No 5 - octobre 2018

Energie - Oncologie Médecine pharmaceutique Financement uniforme - oui, mais

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PERSPECTIVES<br />

32. Nicholls SJ, Puri R, Anderson T, et al.: Effect<br />

of evolocumab on progression of coronary<br />

disease in statin-treated patients: The<br />

GLAGOV randomized clinical trial. JAMA<br />

2016; 316: 2373–2384.<br />

33. Sabatine MS, Giugliano RP, Keech AC, et al.:<br />

Evolocumab and clinical outcomes in patients<br />

with cardiovascular disease. N Engl J<br />

Med 2017; 376: 1713–1722.<br />

34. Blom DJ, Hala T, Bolognese M, et al.: A 52-<br />

week placebo-controlled trial of evolocumab<br />

in hyperlipidemia. N Engl J Med 2014; 370:<br />

1809–1819.<br />

35. Sabatine MS, Giugliano RP, Wiviott SD, et al.:<br />

Efficacy and safety of evolocumab in reducing<br />

lipids and cardiovascular events. N Engl<br />

J Med 2015; 372: 1500–1509.<br />

36. Roth EM, McKenney JM: ODYSSEY MONO: effect<br />

of alirocumab 75 mg subcutaneously every<br />

2 weeks as monotherapy versus ezetimibe over<br />

24 weeks. Future Cardiol 2015; 11: 27–37.<br />

37. Koren MJ, Lundqvist P, Bolognese M, et al.:<br />

Anti-PCSK9 monotherapy for hypercholesterolemia:<br />

the MENDEL-2 randomized, controlled<br />

phase III clinical trial of evolocumab.<br />

J Am Coll Cardiol 2014; 63: 2531–2540.<br />

38. Heigl F, Hettich R, Lotz N, et al.: Efficacy,<br />

safety, and tolerability of long-term lipoprotein<br />

apheresis in patients with LDL- or Lp(a)<br />

hyperlipoproteinemia: Findings gathered<br />

from more than 36000 treatments at one<br />

center in Germany. Atheroscler Suppl 2015;<br />

18: 154–162.<br />

39. Schettler VJ, Neumann CL, Peter C, et al.: The<br />

German Lipoprotein Apheresis Registry<br />

(GLAR) - almost 5 years on. Clin Res Cardiol<br />

Suppl 2017; 12 (Suppl 1): 44–49.<br />

40. Cuchel M, Meagher EA, du Toit Theron H, et<br />

al.: Phase 3 HoFH Lomitapide Study investigators.<br />

Efficacy and safety of a microsomal<br />

triglyceride transfer protein inhibitor in patients<br />

with homozygous familial hypercholesterolaemia:<br />

a single-arm, open-label,<br />

phase 3 study. Lancet 2013; 381: 40–46.<br />

41. Corsini A, Ceska R: Drug-drug interactions<br />

with statins: will pitavastatin overcome the<br />

statins› Achilles› heel? Curr Med Res Opin<br />

2011; 27: 1551–1562.<br />

42. Swiss Atherosclerosis Association. www.agla.<br />

ch. Letzter Zugriff: 6.7.2017.<br />

43. Mach F, <strong>No</strong>ll G, Riesen WF, Sudano I: PCSK9-<br />

Hemmung mit Antikörpern: die Resultate<br />

der Phase-III Studienprogramme. Cardiovasc<br />

Med 2017; 20: 123–131.<br />

Antworten zu den Lernfragen<br />

1. Alle Antworten sind richtig.<br />

2. Antworten a) und c) sind richtig.<br />

3. Antworten a), b), c) und e) sind richtig.<br />

Photo: Pierre-Yves Massot. Espace publicitaire offert.<br />

Du rire et du rêve pour nos enfants hospitalisés<br />

Grâce à vos dons, les enfants hospitalisés reçoivent<br />

chaque semaine la visite des docteurs Rêves.<br />

Merci pour votre soutien.<br />

CCP 10-61645-5 | theodora.org<br />

VSAOJournal_178x133_CH-F-D.indd 1 11.04.17 16:15<br />

N° 5 Octobre <strong>2018</strong><br />

VSAO <strong>JOURNAL</strong> <strong>ASMAC</strong><br />

49

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