mécanismes moléculaires de l'hypertrophie ventriculaire gauche

236 G. CHOUKROUN ET COLL.67. CHOUKROUN G, HAJJAR R, FRY S et al. Regulation of cardiac hypertrophy in vivo by the stressactivatedprotein kinases/c-Jun NH(2)-terminal kinases. J Clin Invest, 1999, 104, 391-398.68. ZECHNER D, THUERAUF DJ, HANFORD DS et al. A role for the p38 mitogen-activated protein kinasepathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression.J Cell Biol, 1997, 139, 115-127.69. WANG Y, HUANG S, SAH VP et al. Cardiac muscle cell hypertrophy and apoptosis induced bydistinct members of the p38 mitogen-activated protein kinase family. J Biol Chem, 1998, 273,2161-2168.70. NEMOTO S, SHENG Z, LIN A. Opposing effects of Jun kinase and p38 mitogen-activated proteinkinases on cardiomyocyte hypertrophy. Mol Cell Biol, 1998, 18, 3518-3526.71. WHITMARSH AJ, YANG SH, SU MS et al. Role of p38 and JNK mitogen-activated protein kinasesin activation of ternary complex factors. Mol Cell Biol, 1997, 17, 2360-2371.72. KLEE CB, REN H, WANG X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin.J Biol Chem, 1998, 273, 13367-13370.73. RAO A, LUO C, HOGAN PG. Transcription factors of the NFAT family : regulation and function.Annu Rev Immunol, 1997, 15, 707-747.74. SHAW KT, HO AM, RAGHAVAN A et al. Immunosuppressive drugs prevent a rapid dephosphorylationof transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci USA, 1995,92, 11205-11209.75. MOLKENTIN JD, LU JR, ANTOS CL et al. A calcineurin-dependent transcriptional pathway for cardiachypertrophy. Cell, 1998, 93, 215-228.76. SUSSMAN MA, LIM HW, GUDE N et al. Prevention of cardiac hypertrophy in mice by calcineurininhibition. Science, 1998, 281, 1690-1693.77. MEGURO T, HONG C, ASAI K et al. Cyclosporine attenuates pressure-overload hypertrophy in micewhile enhancing susceptibility to decompensation and heart failure. Circ Res, 1999, 84, 735-740.78. DING B, PRICE RL, BORG TK et al. Pressure overload induces severe hypertrophy in mice treatedwith cyclosporine, an inhibitor of calcineurin. Circ Res, 1999, 84, 729-734.79. ZHANG W, KOWAL RC, RUSNAK F et al. Failure of calcineurin inhibitors to prevent pressure-overloadleft ventricular hypertrophy in rats. Circ Res, 1999, 84, 722-728.80. MULLER JG, NEMOTO S, LASER M et al. Calcineurin inhibition and cardiac hypertrophy. Science,1998, 282, 1007.81. HAQ S, CHOUKROUN G, LIM H et al. Differential activation of signal transduction pathways inhuman hearts with hypertrophy versus advanced heart failure. Circulation, 2001, 103, 670-677.82. PELLEGRINI S, DUSANTER-FOURT I. The structure, regulation and function of the Janus kinases (JAKs)and the signal transducers and activators of transcription (STATs). Eur J biochem, 1997, 248, 615-633.83. SHENG Z, KNOWLTON K, CHEN J et al. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosisvia a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1signals for myocardial cell hypertrophy. J Biol Chem, 1997, 272, 5783-5791.84. PAN J, FUKUDA K, KODAMA H et al. Role of angiotensin II in activation of the JAK/STAT pathwayinduced by acute pressure overload in the rat heart. Circ Res, 1997, 81, 611-617.85. FULLER SJ, MYNETT JR, SUGDEN PH. Stimulation of cardiac protein synthesis by insulin-like growthfactors. Biochem J, 1992, 282, 85-90.86. ALESSI DR, JAMES SR, DOWNES CP et al. Characterization of a 3-phosphoinositide-dependent proteinkinase which phosphorylates and activates protein kinase Bα. Curr Biol, 1997, 7, 261-269.87. MARTE BM, DOWNWARD J. PKB/Akt : connecting phosphoinositide 3-kinase to cell survival andbeyond. Trend Biol Sci, 1997, 22, 355-358.88. PROUD CG. p70 S6 kinase : an enigma with variations. Trends Biochem Sci, 1996, 21, 181-185.89. HAQ S, CHOUKROUN G, KANG ZB et al. Glycogen synthase kinase-3beta is a negative regulator ofcardiomyocyte hypertrophy. J Cell Biol, 2000, 151, 117-30.