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<strong>Given</strong> <strong>Imaging</strong> <strong>France</strong><br />
CONFIDENTIAL
Europe<br />
Implantation des Stations de Travail<br />
Reste du<br />
Monde<br />
USA<br />
Europe<br />
Reste du Monde<br />
TOTAL<br />
2<br />
USA<br />
2 000<br />
850<br />
300<br />
3 150
Pillcam SB & ESO ingéres<br />
Europe<br />
Reste du<br />
Monde<br />
USA<br />
Europe<br />
Reste du Monde<br />
TOTAL<br />
3<br />
USA<br />
296 000<br />
86 900<br />
30 680<br />
413 580
Septembre 2003<br />
64 Centres :<br />
31 CHU-CHR<br />
27 Cabinets Privés<br />
5 Hop. Privés -<br />
Cliniques<br />
1 Centre M2A<br />
Liste des Centres Référence<br />
CHU – CHR<br />
CHP - CLINIQUES<br />
Cabinets PRIVES Centre M2A<br />
Pillcam® SB<br />
ingérées :<br />
11 000<br />
Nombre Systèmes en <strong>France</strong><br />
Cliniques<br />
CHU<br />
CHG<br />
Cliniques<br />
Cabinets<br />
Station Travail <strong>Given</strong> <strong>Imaging</strong><br />
Cabinets<br />
4<br />
CHG<br />
40<br />
42<br />
9<br />
29<br />
121<br />
CHU
PillCam<br />
Video Capsule<br />
Data Recorder<br />
<strong>Given</strong> <strong>Imaging</strong>… l’ Innovation<br />
PillCam SB<br />
(1st generation)<br />
1.0<br />
RAPID Workstation 1.0<br />
• Autoview<br />
mode<br />
2001<br />
PillCam<br />
SB<br />
(2 nd<br />
generation)<br />
1.4<br />
• Localization<br />
• Suspected<br />
Bleeding<br />
Indicator<br />
2002<br />
Patency<br />
Capsule<br />
1.5<br />
Booster<br />
2.0<br />
Multiview<br />
2003<br />
5<br />
PIllCamE<br />
SO<br />
Pediatric Kit<br />
2.0<br />
3.0<br />
• Color bar<br />
• Zoom<br />
• New reporting<br />
• Quad View<br />
• Fast View<br />
2004<br />
PIllCam<br />
Colon<br />
(Initial Trials)<br />
RapidAccess<br />
Rapid 4.0<br />
Significant<br />
Reduction<br />
in review<br />
time<br />
2005<br />
PillCam<br />
Colon<br />
(Launch)<br />
PillCam<br />
Gastric<br />
Additional<br />
Features for<br />
Improved<br />
Performance<br />
and<br />
Efficiencies<br />
2006 and<br />
beyond
200<br />
180<br />
160<br />
140<br />
120<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
3<br />
Le “portefolio” de Brevets !<br />
Patents by Type of Invention<br />
Capsule Recorder Workstation System<br />
4<br />
8<br />
20<br />
51<br />
1997 1998 1999 2000 2001 2002 2003 2004 2005 to<br />
date<br />
6<br />
82<br />
Issued Pending<br />
109<br />
161<br />
182
350<br />
300<br />
250<br />
200<br />
150<br />
100<br />
50<br />
0<br />
Revues Majeures : > 300 publications sur<br />
Pillcam® SB<br />
Q1/00 Q2/00 Q3/00 Q4/00 Q1/01 Q2/01 Q3/01 Q4/01 Q1/02 Q2/02 Q3/02 Q4/02 Q1/03 Q2/03 Q3/03 Q4/03 Q1/04 Q2/04 Q3/04 Q4/04 Q1/05 Q2/05<br />
General Bleeding Pediatrics Crohn's Cancer Celiac<br />
7
Pillcam® SB<br />
8
PillCam SB ( Small Bowel )<br />
Capsule Components<br />
9<br />
1. Optical dome<br />
2. Lens holder<br />
3. Lens<br />
4. Illuminating LEDs (light emitting<br />
diodes)<br />
5. CMOS (Complementary Metal Oxide<br />
Semiconductor) image<br />
6. Battery<br />
7. ASIC (Application Specific Integrated<br />
Circuit) transmitter<br />
8. Antenna<br />
Dimensions:<br />
Diamètre: 11 mm<br />
Longueur: 26 mm<br />
Poids: 3.7gr
PillCam SB Exam Set<br />
2<br />
1<br />
3<br />
10<br />
1. The PillCam<br />
Capsule<br />
2. SensorArray SB<br />
3. <strong>Given</strong> ®<br />
DataRecorder
Images/Indications<br />
PillCam SB Video Capsule<br />
11
Pillcam® Capsule SB<br />
Villosités Normales<br />
12
Pillcam® Capsule SB<br />
Bleeding<br />
13
Pillcam® Capsule SB<br />
14<br />
Crohn
Pillcam® Capsule SB<br />
15<br />
Coeliac
Pillcam® Capsule SB<br />
Tumeur du Grêle<br />
16
Pillcam® Capsule SB<br />
17<br />
AINS
Pillcam® ESO<br />
18
New procedure<br />
2. Lie on right side, ingest Capsule with sip of water, and stay in right side<br />
position<br />
0:00 � 7:00 min<br />
19<br />
Gralnek et al. Endoscopy (in press)<br />
Drink 15 ml sips of water every ~30 sec.
36<br />
Study Images<br />
Original Procedure New Procedure<br />
TT = 00:13 min TT = 00:09 min<br />
20
RAPID Atlas<br />
On/Off<br />
QuickView<br />
v4<br />
Automatic<br />
Viewing Mode<br />
v4<br />
RAPID® 4 : Quick View A-Mode<br />
21
RAPID Access ®<br />
• Visualisation des images en direct !<br />
• controle vidange gastrique et colique<br />
• Initialisation enregistreur DR2 ®<br />
22
Agile Patency Capsule<br />
Procedure Overview<br />
23
SB<br />
– 11 mm x 26 mm<br />
– 1 camera<br />
– 2 frames per second<br />
– Std optics / 1 lens<br />
– Std lighting control<br />
– Std angle of view 140°<br />
– Depth of field 0-30 mm<br />
PillCam SB 2<br />
Next Generation<br />
24<br />
SB 2<br />
– 11 mm x 26 mm<br />
– 1 camera<br />
– 2 frames per second<br />
– New optics / 3 lenses<br />
– Advanced Automatic Light Control<br />
(ALC)<br />
– Extra-wide Angle of View 156°<br />
– Depth of field 0-30 mm
PillCam SB: PillCam SB 2 Comparison<br />
Not to scale, for illustration purposes only<br />
140°<br />
SB 1<br />
25<br />
156°<br />
4.5 mm<br />
Angle of View<br />
PillCam SB<br />
PillCam SB 2
Increased Coverage Area<br />
PillCam SB PillCam SB 2<br />
500 mm 2 1100 mm 2<br />
120% Additional Mucosal Area*<br />
26<br />
* Flat target, 4.5 mm from dome.
PillCam SB and PillCam SB 2<br />
Increased Angle of View (AOV)<br />
PillCam SB<br />
140o AOV<br />
PillCam SB 2 with ALC and RAPID 5<br />
156o AOV<br />
27
Training – Review<br />
of Colon Videos w<br />
Rapid5-SE, V1.1,<br />
August 28, 2006<br />
Pillcam COLON<br />
…<br />
--- Confidential ---<br />
CONFIDENTIAL
PillCam Colon<br />
� New PillCam design<br />
� 2-sided video cameras<br />
� 4 frames / second<br />
� Optimized optics & illumination<br />
control<br />
� 10 hours life time<br />
� Single use<br />
29<br />
Ø11 mm<br />
Investigational Device. Not yet cleared for marketing in the US.<br />
31 mm
PillCam COLON<br />
ICV Ascending Transverse Descending Rectum<br />
30
PillCam COLON<br />
31
MERCI !<br />
32
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