8. Filipp, D., Moemeni, B., Ferzoco, A.,Kathirkamathamby, K., Zhang, J., Ballek, O.,Davidson, D., Veillette, A., Julius, M. "LCKdependent Fyn activation requires C-terminusdependent targeting of kinase active LCK to lipidrafts". Journal of Biological Chemistry: <strong>2008</strong>.2. Amiri, F., Paradis, P., Reudelhuber, T.L., Schiffrin, E.L."Vascular inflammation in absence of bloodpressure elevation in transgenic murine modeloverexpressing endothelin-1 in endothelial cells".Journal of Hypertension, 26(6): 1102-1109,<strong>2008</strong>.9. Guo, F., Iclozan, C., Suh, W.-K., Anasetti, C., Yu, X.-Z."CD28 controls differentiation of regulatory T cellsfrom naive CD4 T cells". Journal ofImmunology, 181(4): 2285-2291, <strong>2008</strong>.10. Nunez-Cruz, S., Yeo, W.C.J., Rothman, J., Ojha, P.,Bassiri, H., Juntilla, M., Davidson, D., Veillette,A., Koretzky, G.A., Nichols, K.E. "Differentialrequirement for the SAP-Fyn interaction duringNK T cell development and function". Journal ofImmunology, 181(4): 2311-2320, <strong>2008</strong>.3. Belo, N.O., Sairam, M.R., dos Reis, A.M. "Impairmentof the natriuretic peptide system in follitropinreceptor knockout mice and reversal by estradiol:Implications for obesity-associated hypertensionin menopause". Endocrinology, 149(3): 1399-1406, <strong>2008</strong>.4. Chrétien, M., Seidah, N.G., Basak, A., Mbikay, M."Proprotein convertases as therapeutic targets".Expert Opinion on Therapeutic Targets,12(10): 1289-1300, <strong>2008</strong>.11. Suh, W.-K., Chaudhuri, J. "Lymphocytes in action.Symposium on lymphocyte activation andsignalling". EMBO Reports, 9(9): 841-846, <strong>2008</strong>.12. Swingler, S., Zhou, J., Swingler, C., Dauphin, A.,Greenough, T., Jolicoeur, P., Stevenson, M."Evidence for a pathogenic determinant in HIV-1Nef involved in B cell dysfunction in HIV/AIDS".Cell Host and Microbe, 4(1): 63-76, <strong>2008</strong>.5. Davignon, J. "Les conséquences <strong>des</strong> hyperlipidémies".Le Patient, 1(3): 22-25, <strong>2007</strong>.6. Dewpura, T., Raymond, A., Hamelin, J., Seidah, N.G.,Mbikay, M., Chrétien, M., Mayne, J. "PCSK9 isphosphorylated by a Golgi casein kinase-likekinase ex vivo and circulates as a phosphoproteinin humans". FEBS Journal, 275(13): 3480-3493,<strong>2008</strong>.13. Veillette, A., Zhang, S., Shi, X., Dong, Z., Davidson,D., Zhong, M.-C. "SAP expression in T cells, notin B cells, is required for humoral immunity".Proceedings of the National Academy ofSciences of the United States of America,105(4): 1273-1278, <strong>2008</strong>.7. Ebrahimian, T., Sairam, M.R., Schiffrin, E.L., Touyz,R.M. "Cardiac hypertrophy is associated withaltered thioredoxin and ASK1 signaling in amouse model of menopause". American Journalof Physiology. Heart and CirculatoryPhysiology, <strong>2008</strong>.14. Xiao, Y., Chen, G., Richard, J., Rougeau, N., Li, H.,Seidah, N.G., Cohen, É.A. "Cell-surfaceprocessing of extracellular humanimmunodeficiency virus type 1 Vpr by proproteinconvertases". Virology, 372(2): 384-397, <strong>2008</strong>.15. Zhong, M.-C., Veillette, A. "Control of T lymphocytesignaling by Ly108, a signaling lymphocyticactivation molecule family receptor implicated inautoimmunity". Journal of Biological Chemistry,283(28): 19255-19264, <strong>2008</strong>.MALADIES CARDIOVASCULAIRES ETMÉTABOLIQUES1. Abifadel, M., Bernier, L., Dubuc, G., Nuel, G., Rabes,J.P., Bonneau, J., Marques, A., Marduel, M.,Devillers, M., Erlich, D., Varret, M., Roy, M.,Davignon, J., Boileau, C. "A PCSK9 variant andfamilial combined hyperlipidemia". Journal ofMedical Genetics, <strong>2008</strong>.8. Essalmani, R., Zaid, A., Marcinkiewicz, J.,Chamberland, A., Pasquato, A., Seidah, N.G.,Prat, A. "In vivo functions of the proproteinconvertase PC5/6 during mouse development:Gdf11 is a likely substrate". Proceedings of theNational Academy of Sciences of the UnitedStates of America, 105(15): 5750-5755, <strong>2008</strong>.9. Gauthier, D.J., Lazure, C. "Complementary methods toassist subcellular fractionation in organellarproteomics". Expert Review of Proteomics, 5(4):603-617, <strong>2008</strong>.10. Gauthier, D.J., Sobota, J.A., Ferraro, F., Mains, R.E.,Lazure, C. "Flow cytometry-assisted purificationand proteomic analysis of the corticotropesdense-core secretory granules". Proteomics,8(18): 3848-3861, <strong>2008</strong>.11. Georges, R., Nemer, G., Morin, M., Lefebvre, C.,Nemer, M. "Distinct expression and function ofalternatively spliced Tbx5 isoforms in cell growthand differentiation". Molecular and CellularBiology, 28(12): 4052-4067, <strong>2008</strong>.49
12. Gorski, J.P., Huffman, N.T., Cui, C., Henderson, E.P.,Midura, R.J., Seidah, N.G. "Potential role ofproprotein convertase SKI-1 in the mineralizationof primary bone". Cells Tissues Organs, <strong>2008</strong>."Carboxyl-terminal disulfide bond of acidsphingomyelinase is critical for its secretion andenzymatic function". Biochemistry, 46(51):14969-14978, <strong>2007</strong>.13. Janvier, M.-A., Durand, L.-G., Roy-Cardinal, M.-H.,Renaud, I., Chayer, B., Bigras, P., de Guise, J.,Soulez, G., Cloutier, G. "Performance evaluationof a medical robotic 3D-ultrasound imagingsystem". Medical Image Analysis, 12(3): 275-290, <strong>2008</strong>.14. Javeshghani, D., Sairam, M.R., Schiffrin, E.L., Touyz,R.M. "Increased blood pressure, vascularinflammation, and endothelial dysfunction inandrogen-deficient follitropin receptor knockoutmale mice". Journal of the American Society ofHypertension, 1(5): 353-361, <strong>2007</strong>.15. Kantak, K.M., Singh, T., Kerstetter, K.A., Dembro,K.A., Mutebi, M.M., Harvey, R.C., Deschepper,C.F., Dwoskin, L.P. "Advancing the spontaneoushypertensive rat model of attentiondeficit/hyperactivity disorder". BehavioralNeuroscience, 122(2): 340-357, <strong>2008</strong>.16. Khairallah, M., Khairallah, R.J., Young, M.E., Allen,B.G., Gillis, M.A., Danialou, G., Deschepper,C.F., Petrof, B.J., Des Rosiers, C. "Sildenafil andcardiomyocyte-specific cGMP signaling preventcardiomyopathic changes associated withdystrophin deficiency". Proceedings of theNational Academy of Sciences of the UnitedStates of America, 105(19): 7028-33, <strong>2008</strong>.21. Mayer, G., Hamelin, J., Asselin, M.-C., Pasquato, A.,Marcinkiewicz, E., Tang, M., Tabibzadeh, S.,Seidah, N.G. "The regulated cell-surfacezymogen activation of the proprotein convertasePC5A directs the processing of its secretorysubstrates". Journal of Biological Chemistry,283(4): 2373-2384, <strong>2008</strong>.22. Mayer, G., Poirier, S., Seidah, N.G. "Annexin A2 is aC-terminal PCSK9 binding protein that regulatesendogenous LDL receptor levels". Journal ofBiological Chemistry, <strong>2008</strong>.23. Ozden, S., Lucas-Hourani, M., Ceccaldi, P.-E., Basak,A., Valentine, M., Benjannet, S., Hamelin, J.,Jacob, Y., Mamchaoui, K., Mouly, V., Desprès, P.,Gessain, A., Butler-Browne, G., Chrétien, M.,Tangy, F., Vidalain, P.-O., Seidah, N.G."Inhibition of chikungunya virus infection incultured human muscle cells by furin inhibitors:Impairment of the maturation of the E2 surfaceglycoprotein". Journal of Biological Chemistry,283(32): 21899-21908, <strong>2008</strong>.24. Pasquato, A., Dettin, M., Basak, A., Gambaretto, R.,Tonin, L., Seidah, N.G., Di Bello, C. "Heparinenhances the furin cleavage of HIV-1 gp160pepti<strong>des</strong>". FEBS Letters, 581(30): 5807-5813,<strong>2007</strong>.17. Khairallah, R.J., Khairallah, M., Gélinas, R., Bouchard,B., Young, M.E., Allen, B.G., Lopaschuk, G.D.,Deschepper, C.F., Des Rosiers, C. "Cyclic GMPsignaling in cardiomyocytes modulates fatty acidtrafficking and prevents triglyceride accumulation".Journal of Molecular and Cellular Cardiology,45(2): 230-239, <strong>2008</strong>.18. Kyrönlahti, A., Rämö, M., Tamminen, M., Unkila-Kallio,L., Butzow, R., Leminen, A., Nemer, M., Rahman,N., Huhtaniemi, I., Heikinheimo, M., Anttonen, M."GATA-4 regulates Bcl-2 expression in ovariangranulosa cell tumors". Endocrinology, <strong>2008</strong>.19. Lapierre, M., Siegfried, G., Scamuffa, N., Bontemps,Y., Calvo, F., Seidah, N.G., Khatib, A.M."Opposing function of the proprotein convertasesfurin and PACE4 on breast cancer cells'malignant phenotypes: role of tissue inhibitors ofmetalloproteinase-1". Cancer Research, 67(19):9030-9034, <strong>2007</strong>.25. Pasquato, A., Seidah, N.G. "The H5N1 influenzavariant Fujian-like hemagglutinin selectedfollowing vaccination exhibits a compromised furincleavage: Neurological consequences of highlypathogenic Fujian H5N1 strains". Journal ofMolecular Neuroscience, 35(3): 339-343, <strong>2008</strong>.26. Petcu, M., Dias, J.P., Ongali, B., Thibault, G.,Neugebauer, W., Couture, R. "Role of kinin B 1and B 2 receptors in a rat model of neuropathicpain". International Immunopharmacology,8(2): 188-196, <strong>2008</strong>.27. Poirier, S., Mayer, G., Benjannet, S., Bergeron, E.,Marcinkiewicz, J., Nassoury, N., Mayer, H., Nimpf,J., Prat, A., Seidah, N.G. "The proproteinconvertase PCSK9 induces the degradation oflow density lipoprotein receptor (LDLR) and itsclosest family members VLDLR and ApoER2".Journal of Biological Chemistry, 283(4): 2363-2372, <strong>2008</strong>.20. Lee, C.Y., Tamura, T., Rabah, N., Lee, D.Y., Ruel, I.,Hafiane, A., Iatan, I., Nyholt, D., Laporte, F.,Lazure, C., Wada, I., Krimbou, L., Genest, J.28. Rivard, K., Paradis, P., Nemer, M., Fiset, C. "Cardiacspecificoverexpression of the human type 1angiotensin II receptor causes delayed50
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