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Actualités dans la gestion des syndromes coronariens aigus

Actualités dans la gestion des syndromes coronariens aigus

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Potential Risks of Combining Different<br />

Antithrombotic Drugs<br />

Unfractionated<br />

Heparin<br />

(UHF)<br />

Low Molecu<strong>la</strong>r<br />

Weight Heparin<br />

(Enoxaparin sc)<br />

Fondaparinux<br />

Bivalirudin<br />

Half-Life<br />

3 Hrs 6 Hrs 4 Hrs 0.3 Hrs<br />

STEMI: 0.75 mg/kg bolus<br />

followed by infusion 1.75<br />

mg/kg/h<br />

Dose/Kg 30-120 mg/Kg 1 mg/Kg 2.5 mg sc<br />

NSTE-ACS: 0.1 mg/kg<br />

bolus followed by infusion<br />

0.25 mg/kg/h<br />

(if PCI, additional 0.5<br />

mg/kg IV bolus followed<br />

by infusion 1.75 mg/kg/h)<br />

Monitoring<br />

ACT/aPTT<br />

Factor X (not<br />

required)<br />

Not required<br />

ACT (not required)<br />

Inactivation<br />

Protamine<br />

Sulphate<br />

n.a.<br />

n.a.<br />

n.a.

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