Actualités dans la gestion des syndromes coronariens aigus
Actualités dans la gestion des syndromes coronariens aigus Actualités dans la gestion des syndromes coronariens aigus
Primary Outcome Measures (ITT) Diff = -2.9% [-4.9,-0.8] RR = 0.76 [0.63,0.92] P NI ≤ 0.0001 sup = 0.006 P sup Diff = -3.3% [-4.0,-1.6] RR = 0.60 [0.46,0.77] P NI ≤ 0.0001 sup ≤ 0.0001 P sup Diff = 0.0% [-1.6,1.5] RR = 0.99 [0.76,1.30] sup = 1.00 P sup 1° endpoint 1° endpoint *Not related to CABG **MACE = All cause death, reinfarction, ischemic TVR or stroke
1-Year Death or Reinfarction Death or MI (%) Number at risk Bivalirudin alone Heparin+GPIIb/IIIa 10 9 8 7 6 5 4 3 2 1 0 Bivalirudin alone (n=1800) Heparin + GPIIb/IIIa (n=1802) 4.5% 3.8% ∆ = 0.7% P=0.30 0 1 2 3 4 5 6 7 8 9 10 11 12 Time in Months HR [95%CI] = 0.77 [0.61, 0.98] P=0.04 1800 1670 1638 1617 1469 1802 1648 1617 1593 1431 8.5% 6.6% ∆ = 1.9%
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Primary Outcome Measures (ITT)<br />
Diff = -2.9% [-4.9,-0.8]<br />
RR = 0.76 [0.63,0.92]<br />
P NI ≤ 0.0001<br />
sup<br />
= 0.006<br />
P sup<br />
Diff = -3.3% [-4.0,-1.6]<br />
RR = 0.60 [0.46,0.77]<br />
P NI ≤ 0.0001<br />
sup<br />
≤ 0.0001<br />
P sup<br />
Diff = 0.0% [-1.6,1.5]<br />
RR = 0.99 [0.76,1.30]<br />
sup<br />
= 1.00<br />
P sup<br />
1° endpoint 1° endpoint<br />
*Not re<strong>la</strong>ted to CABG<br />
**MACE = All cause death, reinfarction, ischemic TVR or stroke