Actualités dans la gestion des syndromes coronariens aigus
Actualités dans la gestion des syndromes coronariens aigus Actualités dans la gestion des syndromes coronariens aigus
Inhibition of Platelet Aggregation (IPA) at 24 Hours (Healthy Volunteers) Inhibition of platelet aggregation (%) 100.0 80.0 60.0 40.0 20.0 0.0 -20.0 Interpatient variability Response to clopidogrel *Responder = ≥25% IPA at 4 and 24 hours. Brandt et al. Am Heart J. 2007;153:66e9-66e16. Clopidogrel responder Clopidogrel nonresponder Response to prasugrel Interpatient variability
15 TRITON study : Primary Endpoint CV Death,MI,Stroke Primary Endpoint (%) 10 5 HR 0.77 P=0.0001 HR 0.80 P=0.0003 Clopidogrel Prasugrel 12.1% (781) 9.9% (643) HR 0.81 (0.73-0.90) P=0.0004 NNT= 46 0 ITT= 13,608 LTFU = 14 (0.1%) 0 30 60 90 180 270 360 450 Days Wiviott N Engl J Med 2007;357:2001
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15<br />
TRITON study : Primary Endpoint CV<br />
Death,MI,Stroke<br />
Primary Endpoint (%)<br />
10<br />
5<br />
HR 0.77<br />
P=0.0001<br />
HR 0.80<br />
P=0.0003<br />
Clopidogrel<br />
Prasugrel<br />
12.1%<br />
(781)<br />
9.9%<br />
(643)<br />
HR 0.81<br />
(0.73-0.90)<br />
P=0.0004<br />
NNT= 46<br />
0<br />
ITT= 13,608 LTFU = 14 (0.1%)<br />
0 30 60 90 180 270 360 450<br />
Days Wiviott N Engl J Med 2007;357:2001
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