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Thursday, May 29 >>> morning<br />

Motor neuron diseases<br />

8.30 am-10.00 am Plenary lectures XAuditorium<br />

Chairperson > Mimoun Azzouz<br />

8.30 am-9.15 am Vincent Meininger, France<br />

> Biomarkers and clinical trials in amyotrophic lateral sclerosis<br />

9.15 am-10.00 am Judith Melki, Israel<br />

> Genetics and mo<strong>de</strong>l systems in upper and lower motor neuron diseases<br />

10.00 am-10.30 am Break<br />

10.30 am-12.00 am Parallel Symposia<br />

‹Molecular basis of motor neuron diseases:<br />

insights from new mo<strong>de</strong>ls systems XSalle Endoume<br />

Chairpersons > Laurent Schaeffer and Georg Haase<br />

Don W. Cleveland, USA<br />

> ALS: a disease of motor neurons and their non-neuronal neighbors<br />

Francesco Paolo di Giorgio, USA<br />

> Interrogating disease states using embryonic stem cells: a case study in ALS<br />

Arthur Burghes, USA<br />

> A genetic approach to the critical molecular patheway in spinal muscular atrophy<br />

using zebrafish and mice<br />

Programme > Thursday, May 29<br />

‹Genetics and Biomarkers of motor neuron diseases XAmphitheatre Callelongue<br />

Chairpersons > Suzanne Lefebvre and Jean-Pierre Azulay<br />

Nazli Basak, Turkey<br />

> Genetics of ALS<br />

Pascale Saugier Veber, France<br />

> Sensitive assays for mea<strong>sur</strong>ing SMN gene copy number and mRNA in SMA patients<br />

Utz Fischer, Germany<br />

> Un<strong>de</strong>rstanding the molecular basis of spinal muscular atrophy<br />

‹Therapeutics in SMA and ALS: results and perspectives XAuditorium<br />

Chairpersons > Bertrand Fontaine and Louis Viollet<br />

Enrico Bertini, Italy<br />

> Bottlenecks in trials for SMA<br />

12.00 am-1.00 pm Lunch break<br />

Jean Pouget, France<br />

> Learning from clinical trials and standards of care in ALS<br />

Martine Barkats , France<br />

> AAV-mediated gene transfer in the central nervous system of a feline mo<strong>de</strong>l of SMA<br />

14

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