2011-2012 - IRCM

distribution and disappearance of ingested water
labeled with D 2 O in humans. Eur J Appl Physiol
2012; 112 (6): 2213-2222
51. Pighon A, Gutkowska J, Jankowski M, Rabasa-
Lhoret R, Lavoie JM. Exercise training in
ovariectomized rats stimulates estrogenic-like
effects on expression of genes involved in lipid
accumulation and subclinical inflammation in liver.
Metabolism 2011 May;60(5):629-39.
52. Prat A, Behrendt M, Marcinkiewicz E, Boridy S,
Sairam MR, Seidah NG, and Maysinger D.
Chronic estrogen deficiency leads to glial cell
activation and hypertrophy in a novel mouse
model of Alzheimer’s disease (AD). J Aging
Research 2011:251517, 2011.
53. Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie
ME, Messier V, Sladek R, Rabasa-Lhoret R.
Characterizing the profile of obese patients who
are metabolically healthy. Int J Obes (Lond) 2011
Jul;35(7):971-81.
54. Punthakee Z et al; TIDE Trial Investigators. Design,
history and results of the thiazolidinedione
intervention with vitamin D evaluation (TIDE)
randomized controlled trial. Diabetologia 2012
Jan; 55 (1): 36-45. Epub 2011 Oct 29
55. Refaie S, Gagnon S, Gagnon H, Desjardins R,
D'Anjou F, D'Orleans-Juste P, Zhu X, Steiner DF,
Seidah NG, Lazure C, Salzet M and Day R.
Disruption of Proprotein Convertase 1/3 (PC1/3)
Expression in Mice Causes Innate Immune
Defects and Uncontrolled Cytokine Secretion. J
Biol Chem 287: 14703-14717, 2012.
56. Reudelhuber TL. The interaction between prorenin,
renin and the (pro)renin receptor: time to rethink
the role in hypertension. Curr Opin Nephrol
Hypertens 21(2): 137-41, 2012.
57. Richard C, Couture P, Desroches S, Benjannet S,
Seidah NG, Lichtenstein AH and Lamarche B.
Effect of the Mediterranean diet with and without
weight loss on surrogate markers of cholesterol
homeostasis in men with the metabolic syndrome.
Br J Nutr 1-7, 2011.
58. Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten
ME, Prat A and Seidah NG. PCSK9 reduces the
protein levels of the LDL receptor in mouse brain
during development and after ischemic stroke. J
Lipid Res 52: 1383-1391, 2011.
59. Salem H, Bissonnette S, Saint-Pierre N, Tardif A,
Wassef H, Baass A, Dufour R, Faraj M. ApoBlipoproteins
promote delayed plasma clearance of
triglyceride-rich lipoproteins in human adipose
tissue. J Lipid Res.
60. Scott-Boyer MP, Tayeb A, Imholte GC, Labbe A,
Deschepper CF and Gottardo R. An Integrated
Hierarchical Bayesian Model for Multivariate
eQTL Mapping. Stat Applic Genetics Mol Biol
11: Article 6, 2012.
61. Seidah N.G., Poirier S, Denis M, Parker R, Miao B,
Mapelli C, Prat A, Wassef H, Davignon J, Hajjar
KA and Mayer G. Annexin A2 is a natural
extrahepatic inhibitor of the PCSK9-induced LDL
receptor degradation. PLoS ONE 2012.
62. Seidah NG and Prat A. The biology and therapeutic
targeting of the proprotein convertases. Nat Rev
Drug Discov 11: 367-383, 2012.
63. Singh PP et al. Bypass Angioplasty Revascularization
Investigation 2 Diabetes Study Group. The
prevalence and predictors of an abnormal anklebrachial
index in the Bypass Angioplasty
Revascularization Investigation 2 Diabetes (BARI
2D) trial. Diabetes Care 2011; 34:464-7. Rabasa-
Lhoret R collaborator.
64. Stein EA, Gipe D, Bergeron J, Gaudet D, Weiss R,
Dufour R, Wu R, Pordy R. Effect of a monoclonal
antibody to PCSK9, REGN727/SAR236553, to
reduce low-density lipoprotein cholesterol in
patients with heterozygous familial
hypercholesterolaemia on stable statin dose with
or without ezetimibe therapy: a phase 2
randomised controlled trial. Lancet
DOI:10.1016/S0140-6736(12)60771-5.
65. Stein EA, Dufour R, Gagne C, Gaudet D, East C,
Donovan JM, Chin W, Tribble DL, McGowan M.
Apolipoprotein B synthesis inhibition with
Mipomersen in heterozygous familial
hypercholesterolemia: results of a randomized,
double blind, placebo controlled trial to assess
efficacy and safety as add-on therapy in patient
with coronary artery disease. Circulation
66. St-Onge M, Rabasa-Lhoret R, Strychar I, Faraj M,
Doucet É, Lavoie JM. Impact of energy restriction
with or without resistance training on energy
metabolism in postmenopausal overweight and
obese women. A MONET GROUP Study.
Menopause.
67. Sun X, Essalmani R, Susan-Resiga D, Prat A and
Seidah NG. Latent TGF-beta binding proteins-2
and -3 inhibit the proprotein convertase 5/6A. J
Biol Chem 286: 29063-29073, 2011.
68. Susan-Resiga D, Essalmani R, Hamelin J, Asselin
MC, Benjannet S, Chamberland A, Day R,
Szumska D, Constam D, Bhattacharya S, Prat A
and Seidah NG. Furin Is the Major Processing
Enzyme of the Cardiac-specific Growth Factor
Bone Morphogenetic Protein 10. J Biol Chem
286: 22785-22794, 2011.
69. Tassew NG, Charish J, Seidah NG and Monnier PP.
SKI-1 and Furin generate multiple RGMa
fragments that regulate axonal growth. Dev Cell
22: 391-402, 2012.
54