2011-2012 - IRCM

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10. Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2011; 60:258-268. 11. Brazeau AS, Karelis AD, Mignault D, Lacroix M-J, Prud’homme D, Rémi Rabasa-Lhoret. Precision of the SenseWear Armband during Ergocycling (Evaluation of a Portable Motion Sensor to Assess Energy Expenditure During Ergocycling). Int J A Sport Med 2011; 36: 339-343 12. Brazeau AS, Karelis AD, Mignault D, Lacroix M-J, Prud’homme D, Rémi Rabasa-Lhoret. Test-retest Reliability of a Portable Monitor to Assess Energy Expenditure. Appl Physiol Nutr Metab 2011 Jun;36(3):339-43. 13. Brazeau AS, Karelis AD, Mignault D, Lacroix MJ, Prud’homme D, Rabasa-Lhoret R. Accuracy of the SenseWear Armand TM during ergocycling. Int J Sports Med 2011 Oct; 32 (10): 761-4. Epub 2011 Sep 12 14.Brazeau AS, Leroux C, Mircescu H, Rabasa-Lhoret R. Physical activity level and body composition among adults with type 1 diabetes. Diabetic Medicine (In Press). 15. Brazeau AS, Mircescu H, Desjardins K, Dubé MC, Weisnagel J, Lavoie C, Rabasa-Lhoret R. The barriers to physical activity in type 1 diabetes scale (BAPAD-1): Predictive validity and reliability. Diabetes Metab 2012; 38 (2): 164-170 16. Burri DJ, Pasqual G, Rochat C, Seidah NG, Pasquato A and Kunz S. Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. J Virol 86: 4935-4946, 2012. 17. Campbell NR, Gilbert RE, Leiter LA, Larochelle P, Tobe S, Chockalingam A, Ward R, Morris D, Tsuyuki RT, Harris SB. Hypertension in people with type 2 diabetes: Update on pharmacologic management. Can Fam Physician 2011; 57 (9): 997-1002 18. Campbell NRC, Gilbert RE, Leiter LA, Larochelle P, Tobe S, Chockalingam A, Ward R, Morris D, Tsuyuki RT, Harris S. Hypertension revisited. (Letters / Correspondance) Can Fam Physician 2012; 58: 634-636 19. Chabot K, Rabasa-Lhoret R, Gauthier MS. Le paradoxe de l’obèse insulino-sensible. Obésité 2012; 7 : 148-153 20. Côté I, Yasari S, Pighon A, Barsalani R, Rabasa- Lhoret R, Prud’homme D, Lavoie JM. Liver fat accumulation may be dissociated from adiposity gain in ovariectomized rats. Climacteric 2012 Jan 23 21. Coderre L, Fadainia C, Belson L, Belisle V, Ziai S, Maillhot G, Berthiaume Y, Rabasa-Lhoret R. LDL-cholesterol and insulin are independently associated with body mass index in adult cystic fibrosis patients. Journal of Cystic Fibrosis 22. Davignon J. Pleiotropic effects of pitavastatin. Br J Clin Pharmacol 73: 518-535, 2012. 23. Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, Seidah N.G. and Prat A. Gene inactivation of PCSK9 reduces atherosclerosis in mice. Circulation 125: 894-901, 2012. 24. Denis NJ, Palmer-Smith H, Elisma F, Busuttil A, Wright TG, Khalil MB, Prat A, Seidah NG, Chretien M, Mayne J and Figeys D. Quantitative Proteomic Analysis of PCSK9 Gain of Function in Human Hepatic HuH7 Cells. J Proteome Res 10: 2011-2026, 2011. 25. Disse E, Rabasa-Lhoret R, Laville M, Bastard J-P. Is it important to consider how hyperinsulinaemiceuglycaemic clamp results are expressed? Diabetes Metab 2011; 37 (5): 460-461 26. Doyon CY, Brochu M, Messier V, Lavoie ME, Faraj M, Doucet E, Rabasa-Lhoret R, Dionne IJ. Association between abdominal fat (DXA) and its subcomponents (CT Scan) before and after weight loss in obese postmenopausal women: A MONET study. J Obes 2011 27. Drapeau S, Doucet E, Rabasa-Lhoret R, Brochu M, Prud’Homme D, Imbeault P. Improvement in Insulin Sensitivity by Weight loss Does not Affect Hyperinsulinemia Mediated Reduction in Total and High Molecular Weight Adiponectin: A MONET Study. Appl Physiol Nutr Metab 2011; 3 6:191-200. 28. Dream On (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication Ongoing Follow-up) Gerstein HC et al. Long-term effect of rosiglitazone and/or ramipril on the incidence of diabetes. Diabetologia 2011; 54:487-95. Rabasa-Lhoret R collaborator. 29. Elisha B, Guebre-Egziabher F, Vidal H, Bastard JP, Laville M, Rabasa-Lhoret R.From French to mediterranean diet: importance of the omega- 6/omega-3 Fatty acids ratio. World Rev Nutr Diet 2011;102: 81-91. 30. Elisha B, Rabasa-Lhoret R, Messier V, Abdulnour J, Karelis AD. Relationship between the body adiposity index and cardiometabolic risk factors in obese postmenopausal women. Eur J Nutr 2012 Jan 1 52
31. Estall JL. The foxo family in liver: Partners in crime or silent heroes. Invited Editorial. Endocrinology 153(2): 549-551, 2012. 32. Ghadami M, El-Demerdash E, Zhang D, Salama SA, Binhazim AA, Archibong AE, Chen X, Ballard BR, Sairam MR and Al-Hendy A. Bone marrow transplantation restores follicular maturation and steroid hormones production in a mouse model for primary ovarian failure. PLoS One 7:e32462, 2012. 33. Goyer L, Dufour R, Janelle C, Blais C, L’Abbé C, Raymond É, de Champlain J, Larochelle P. Randomized controlled trial on the long-term efficacy of a multifaceted, interdisciplinary lifestyle intervention in reducing cardiovascular risk and improving lifestyle in patients at risk of cardiovascular disease. J Behav Med 2012 March 9 (Epub ahead of print). 34. Guillemot J, Thouennon E, Guerin M, Vallet-Erdtmann V, Ravni A, Montero-Hadjadje M, Lefebvre H, Klein M, Muresan M, Seidah NG, Anouar Y and Yon L. Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma : implications for the production of the tumoral marker EM66. J Mol Endocrinol 2012. 35. Henderson M, Baillargeon JP, Rabasa-Lhoret R, Chiasson JL, Hanley J, Lambert M. Estimating insulin secretion in youth using simple indices derived from the oral glucose tolerance test. Diabetes Metab 36. Henderson M, Rabasa-Lhoret R, Bastard JP, Chiasson JL, Baillargeon JP, Hanley JA, Lambert M. Measuring insulin sensitivity in youth: How do the different indices compare to the gold standard method? Diabetes Metab 2011; 37:72-78. 37. Karelis AD, Rabasa-Lhoret R, Pompilus R, Messier V, Strychar I, Brochu M, Aubertin-Leheudre M. Relationship Between the Bertin Index to Estimate Visceral Adipose Tissue From Dual- Energy X-Ray Absorptiometry and Cardiometabolic Risk Factors Before and After Weight Loss. Obesity (Silver Spring) 2012 Apr; 20 (4): 886-90. 38. Kim W, Essalmani R, Szumska D, Creemers JW, Roebroek AJ, D'Orleans-Juste P, Bhattacharya S, Seidah NG and Prat A. Loss of endothelial furin leads to cardiac malformation and early postnatal death. Mol Cell Biol 2012. 39. Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PCG-1α in adipose tissues. Proc Natl Acad Sci USA 109(24): 9635-9640, 2012 40. Krishnapuram R, Kirk-Ballard H, Dhurandhar EJ, Dubuisson O, Messier V, Rabasa-Lhoret R, Hegde V, Aggarwal S, Dhurandhar NV. Insulin receptor-independent upregulation of cellular glucose uptake. Int J Obes (Lond) 2012 Feb 7 41. Lamarre-Cliche M, Ng Cheong N, Larochelle P. Comparative assessment of four blood pressure measurement methods in hypertensives. Can J Cardiol 2011; 27 (4): 455-460 42. Lavoie MÈ, Rabasa-Lhoret R, Ziai S, Lavoie JC. Blood glutathione peroxidase activity in relation with the risk of cardiovascular diseases in obese women. J Diabetes Metab 2011; 2 (6) 43. Lavoie, M.E., Faraj, M., Strychar, I., Doucet, E., Brochu, M., Lavoie, J.M., Rabasa-Lhoret, R.. « Synergistic effects of physical activity and diet quality on cardiometabolic risk factors in overweight and obese postmenopausal women”. British Journal of Nutrition, 9:1-10, 2012. 44. Leiter LA et al. Identification and Management of Cardiometabolic Risk in Canada. A Position Paper by the Cardiometabolic Risk Working Group. Executive summary. Can J Cardiol 2011; 27(2): 124-131 Rabasa-Lhoret R, co-author of the position statement paper 45. Leiter LA et al. Cardiometabolic Risk in Canada: A detailed analysis and position paper by the Cardiometabolic Risk Working Group. Can J Cardiol 2011; 27: e1-e33 Rabasa-Lhoret R coauthor of the pathophysiology chapter. 46. Marchesi C, Essalmani R, Lemarie CA, Leibovitz E, Ebrahimian T, Paradis P, Seidah NG, Schiffrin EL and Prat A. Inactivation of endothelia proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. J Mol Med 89: 1103-1111, 2011. 47. Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M and Chretien M. Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture. Clin Chem 57: 1415-1423, 2011. 48. Messier V, Rabasa-Lhoret R, Barbat-Artigas S, Elisha B, Karelis AD, Aubertin-Leheudre M. Menopause and sarcopenia: A potential role for sex hormones. Maturitas 2011 Apr;68(4):331-6. 49. Pasquato A, Burri DJ, Traba EG, Hanna-El-Daher L, Seidah NG and Kunz S. Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. Virology 2011. 50. Péronnet F, Mignault D, du Souich P, Vergne S, Le Bellego L, Jimenez L, Rabasa-Lhoret R. Pharmacokinetic analysis of absorption, 53
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RAPPORT DES ACTIVITÉS ACADÉMIQUES
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LES ACTIVITÉS ACADÉMIQUES DE L’
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LES CHERCHEURS ET LEURS AFFILIATION
Page 7 and 8: Louis-Gilles Durand Professeur-cher
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Page 11 and 12: Formation de la relève scientifiqu
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Page 27 and 28: Bourses et distinctions obtenues pa
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Page 31 and 32: Mélanie Laurin, étudiante au doct
Page 33 and 34: RECHERCHE À L’IRCM
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Page 37 and 38: Virologie moléculaire sous la dire
Page 39 and 40: postdoctoraux • Marie-Claude Gaud
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