(R,S)-MTD - THS 10
(R,S)-MTD - THS 10
(R,S)-MTD - THS 10
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QTc [ms]<br />
350 400 450 500<br />
Métaboliseurs lents CYP2B6 ont un intervalle QT plus long<br />
P= 0.017<br />
18 msec<br />
difference<br />
Odds ratio = 6.3<br />
p = 0.003<br />
Female and male<br />
patients with<br />
Normal QT<br />
Borderline QT<br />
Prolonged QT<br />
CYP2B6 *1/*1 CYP2B6 *6/*6<br />
30% > prolonged<br />
or borderline QTc<br />
73% with prolonged<br />
or borderline QTc<br />
Eap et al., Clin Pharmacol Ther 81:719-728, 2007
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