(R,S)-MTD - THS 10
(R,S)-MTD - THS 10
(R,S)-MTD - THS 10
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CYP2B6 stéréosélectif pour (S)-<strong>MTD</strong>, métaboliseurs CYP2B6 ralentis: taux élevés (S)-<strong>MTD</strong><br />
(S)-<strong>MTD</strong> OR (R)-<strong>MTD</strong><br />
0 200 400 600 800 1,000<br />
x 1.3 for (R)-<strong>MTD</strong><br />
p=0.14<br />
x 2 for (S)-<strong>MTD</strong> p=0.0004<br />
Non carriers of<br />
CYP2B6 allele *6<br />
*6 associé avec une activité ralentie<br />
Heterozygous<br />
carriers<br />
Homozygous carriers<br />
*6/*6<br />
Crettol et al., CPT 78:593-604, 2005
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