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(R,S)-MTD - THS 10

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Efavirenz<br />

Methadone Coumarin<br />

Mephobarbital Mephenytoin Propofol<br />

Cyclophosphamide<br />

Bupropion<br />

Inhibiteurs:<br />

Ritonavir<br />

Nelfinavir<br />

Inducteurs:<br />

Efavirenz<br />

Nevirapine<br />

Modafinil<br />

CYP2B6<br />

Gène CYP2B6 très<br />

polymorphique<br />

Ifosfamide<br />

Variabilité<br />

interindividuelle:<br />

> 1 à <strong>10</strong><br />

Activité nulle ou très faible: moins que 3 %<br />

Activité réduite: environ <strong>10</strong> %<br />

Activité normale ou augmentée: environ 90 %

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