24.10.2014 Views

(R,S)-MTD - THS 10

(R,S)-MTD - THS 10

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(R )-methadone plasma levels<br />

(ng/ml)<br />

Cytochrome P-450 (CYP) impliqués dans le<br />

métabolisme de la méthadone<br />

LIVER<br />

CYP2B6<br />

CYP3A4<br />

CYP2D6<br />

<strong>10</strong>00<br />

<strong>10</strong>0<br />

-1 4 9 14 19 24<br />

Time (hours)<br />

INTESTINES<br />

CYP3A4<br />

Jus de pamplemousse bloque CYP3A

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