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Vaccins antigrippaux - Infectiologie

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<strong>Vaccins</strong> : Lesquels ?<br />

• Virus :<br />

- Tués +++ = Inactivés (surfactant)<br />

sous unitaires<br />

fragmentés<br />

- Vivants = Atténués<br />

• Fabrication :<br />

- Œuf embryonné +++<br />

purification +++<br />

- Culture cellulaire = difficile<br />

CEMI 14 - 14/12/2009<br />

<strong>Vaccins</strong> : Lesquels ?<br />

• Constituants : - Ag = 3 ; A=2 ; B=1 mais..<br />

- Excipients = sels<br />

- Conservateur = eventuel<br />

mercuriel (multidose)<br />

- Adjuvants = eventuel<br />

Sels mineraux : Alun<br />

Huile dans eau : MF 59<br />

AS03<br />

AF03<br />

Virosomes<br />

CEMI 14 - 14/12/2009

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