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Implication de la voie alterne du complément dans les ...

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60 M. R. DAHA<br />

également une contribution <strong>du</strong> tissu-même <strong>dans</strong> l’activation <strong>du</strong> <strong>complément</strong>. D’une<br />

part, ces événements sont régulés par différents inhibiteurs <strong>du</strong> <strong>complément</strong> liés à <strong>la</strong><br />

membrane et sont <strong>de</strong> plus contrôlés par <strong>les</strong> inhibiteurs en phase fl ui<strong>de</strong>. D’autre part,<br />

lorsqu’une mo<strong>du</strong><strong>la</strong>tion tissu<strong>la</strong>ire se pro<strong>du</strong>it, celle-ci peut être associée à une perte<br />

<strong>du</strong> contrôle <strong>du</strong> <strong>complément</strong> et à une amplifi cation <strong>de</strong> l’infl ammation. À cet égard,<br />

<strong>la</strong> contribution <strong>de</strong> <strong>la</strong> properdine <strong>de</strong>vrait être reconnue comme un régu<strong>la</strong>teur positif<br />

important <strong>de</strong> l’atteinte tissu<strong>la</strong>ire.<br />

BIBLIOGRAPHIE<br />

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