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Carcinomes infiltrants du sein - epathologies

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Immunophénotype<br />

des carcinomes micropapillaires<br />

• RO + 56 à 93%<br />

• RP + 40 à 82%<br />

• HER2 + 21%<br />

• CK7 +<br />

• CK5/6 , EGFR, c-KIT : -<br />

• Pole apical inversé<br />

- MUC1 +<br />

- E-cadherine -<br />

• VEGF-C / VEFGR3 fortement exprimés<br />

• Forte densité vasculaire<br />

Pettinato et al, Am J Clin Pathol, 2004<br />

Li et al Pathol Int, May 2006<br />

Kim et al, Arch Pathol Lab Med, 2005<br />

Gong et al Histopathology 2005<br />

Marchio et al J Pathol, 2008

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