Receptores tipo Toll: entre el reconocimiento de lo

Receptores tipo Toll: entre el reconocimiento de lo Receptores tipo Toll: entre el reconocimiento de lo

revista.inmunologia.org
from revista.inmunologia.org More from this publisher
30.01.2013 Views

RECEPTORES TIPO TOLL: ENTRE EL RECONOCIMIENTO DE LO NO PROPIO INFECCIOSO Y LAS SEÑALES ENDÓGENAS DE PELIGRO VOL. 25 NUM. 2/ 2006 instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol 2003; 171: 4984-4989. 23. Barton GM, Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol 2002; 14: 380-383. 24. Pasare C, Medzhitov R. Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol 2003; 15: 677-682. 25. Lotz S, Aga E, Wilde I, van Zandbergen G, Hartung T, Solbachet W, Laskay T. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol 2004; 75: 467-477. 26. Hayashi F, Means TK, Luster AD. Toll-like receptors stimulate human neutrophil function. Blood 2003; 102: 2660-2669. 27. Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from toll-like receptors. Science 2004; 304: 1014-1018. 28. Leibovich SJ, Chen JF, Pinhal-Enfield G, Belem PC, Elson G, Rosania A, et al. Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Am J Pathol 2002; 160: 2231-2244. 29. Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman Al, Boons GJ, et al. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol 2003; 163: 711-721. 30. Olah ME, Caldwell CC. Adenosine receptors and mammalian tolllike receptors: synergism in macrophages. Mol Interv 2003; 3: 370- 374. 31. Pollet I, Opina CJ, Zimmerman C, Leong KG, Wong F, Karsan A. Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-kappaB and c-Jun N-terminal kinase. Blood 2003; 102: 1740-1742. 32. McCurdy JD, Olynych TJ, Maher LH, Marshall JS. Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J Immunol 2003; 170: 1625-1629. 33. Varadaradjalou S, Feger F, Thieblemont N, Hamouda NB, Pleau JM, Dy M, et al. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur J Immunol 2003; 33: 899-906. 34. Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD. Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. J Allergy Clin Immunol 2004; 114: 174-182. 35. Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, et al. APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J Immunol 2004; 172: 138-143. 36. Sivori S, Falco M, Della CM, Carlomagno S, Vitale M, Moretta L, et al. CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA 2004; 101: 10116-10121. 128 37. Becker I, Salaiza N, Aguirre M, Delgado J, Carrillo-Carrasco N, Kobeh LG, et al. Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2. Mol Biochem Parasitol 2003; 130: 65-74. 38. Chalifour A, Jeannin P, Gauchat JF, Blaecke A, Malissard M, N´Guyen T, et al. Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood 2004; 104: 1778-1783. 39. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003; 197: 403-411. 40. Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003; 101: 4500-4504. 41. Wagner M, Poeck H, Jahrsdoerfer B, Rothenfusser S, Prell D, Bohle B, et al. IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA. J Immunol 2004; 172: 954-963. 42. Otte JM, Rosenberg IM, Podolsky DK. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003; 124: 1866-1878. 43. Wang PL, Ohura K, Fujii T, Oido-Mori M, Kowashi Y, Kikuchi M, et al. DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues. Biochem Biophys Res Commun 2003; 305: 970-973. 44. Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 2000; 275: 24255-24263. 45. Backhed F, Hornef M. Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat? Microbes Infect 2003; 5: 951-959. 46. Bals R, Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 2004; 23: 327-333. 47. Sha Q, Truong-Tran AQ, Plitt JR, Beck LA, Schleimer RP. Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 2004; 31: 358-364. 48. Soong G, Reddy B, Sokol S, Adamo R, Prince A. TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells. J Clin Invest 2004; 113: 1482-1489. 49. Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, et al. Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci USA 2001; 98: 8774-8779. 50. Wang X, Zhang Z, Louboutin JP, Moser C, Weiner DJ, Wilson JM. Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2. FASEB J 2003; 17: 1727-1729.

INMUNOLOGÍA M. MESA-VILLANUEVA, P.J. PATIÑO 51. Duits LA, Nibbering PH, van Strijen E, Vos JB, Mannesse-Lazeroms SP, van Sterkenburg MA, et al. Rhinovirus increases human betadefensin-2 and -3 mRNA expression in cultured bronchial epithelial cells. FEMS Immunol Med Microbiol 2003; 38: 59-64. 52. Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC, Podolsky DK. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J Immunol 2000; 164: 966-972. 53. Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 2001; 167: 1609-1616. 54. Abreu MT, Arnold ET, Thomas LS, Gonsky R, Zhou Y, Hu B, et al. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem 2002; 277: 20431-20437. 55. Ortega-Cava CF, Ishihara S, Rumi MA, Aziz MM, Kazumori H, Yuki T, et al. Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol 2003; 170: 3977-3985. 56. Hornef MW, Frisan T, Vandewalle A, Normark S, Richter-Dahlfors A. Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med 2002; 195: 559-570. 57. Arron JR, Choi Y. Bone versus immune system. Nature 2000; 408: 535-536. 58. Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003; 423: 337-342. 59. Nair SP, Meghji S, Wilson M, Reddi K, White P, Henderson B. Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 1996; 64: 2371-2380. 60. Asai Y, Hirokawa Y, Niwa K, Ogawa T. Osteoclast differentiation by human osteoblastic cell line SaOS-2 primed with bacterial lipid A. FEMS Immunol Med Microbiol 2003; 38: 71-79. 61. Bi Y, Seabold JM, Kaar SG, Ragab AA, Golberg VM, Andreson JM, et al. Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation. J Bone Miner Res 2001; 16: 2082-2091. 62. Gasper NA, Petty CC, Schrum LW, Marriott I, Bost KL. Bacteriuminduced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4. Infect Immun 2002; 70: 4075- 4082. 63. Kondo A, Koshihara Y, Togari A. Signal transduction system for interleukin-6 synthesis stimulated by lipopolysaccharide in human osteoblasts. J Interferon Cytokine Res 2001; 21: 943-950. 64. Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T, Kobayashi Y, et al. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. J Exp Med 2004; 200: 601-611. 65. Lacroix S, Feinstein D, Rivest S. The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations. Brain Pathol 1998; 8: 625-640. 66. Laflamme N, Rivest S. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gramnegative bacterial cell wall components. FASEB J 2001; 15: 155- 163. 67. Laflamme N, Soucy G, Rivest S. Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J Neurochem 2001; 79: 648-657. 68. Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 2002; 61: 1013-1021. 69. Netea MG, Kullberg BJ, Van der Meer JW. Circulating cytokines as mediators of fever. Clin Infect Dis 2000; 31(Suppl 5): S178-S184. 70. Brochu S, Olivier M, Rivest S. Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. J Neurosci Res 1999; 57: 801-816. 71. Nguyen MD, Julien JP, Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 2002; 3: 216-227. 72. Dantzer R, Wollman EE. [Relationships between the brain and the immune system]. J Soc Biol 2003; 197: 81-88. 73. Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor- 4 complex. J Immunol 2000; 164: 558-561. 74. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001; 276: 31332-31339. 75. Habich C, Baumgart K, Kolb H, Burkart V. The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins. J Immunol 2002; 168: 569-576. 76. Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Issels RD, Wagner H. HSP70 as endogenous stimulus of the Toll/ interleukin-1 receptor signal pathway. J Biol Chem 2002; 277: 15107-15112. 77. Taylor KR, Trowbridge JM, Rudisill JA, Termeer CC, Simon JC, Gallo RL. Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem 2004; 279: 17079-17084. 78. Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002; 168: 5989-5992. 129

INMUNOLOGÍA M. MESA-VILLANUEVA, P.J. PATIÑO<br />

51. Duits LA, Nibbering PH, van Strijen E, Vos JB, Mannesse-Lazeroms<br />

SP, van Sterkenburg MA, et al. Rhinovirus increases human beta<strong>de</strong>fensin-2<br />

and -3 mRNA expression in cultured bronchial epith<strong>el</strong>ial<br />

c<strong>el</strong>ls. FEMS Immunol Med Microbiol 2003; 38: 59-64.<br />

52. Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC,<br />

Podolsky DK. Lipopolysacchari<strong>de</strong> activates distinct signaling<br />

pathways in intestinal epith<strong>el</strong>ial c<strong>el</strong>l lines expressing <strong>Toll</strong>-like<br />

receptors. J Immunol 2000; 164: 966-972.<br />

53. Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M.<br />

Decreased expression of <strong>Toll</strong>-like receptor-4 and MD-2 corr<strong>el</strong>ates<br />

with intestinal epith<strong>el</strong>ial c<strong>el</strong>l protection against dysregulated<br />

proinflammatory gene expression in response to bacterial<br />

lipopolysacchari<strong>de</strong>. J Immunol 2001; 167: 1609-1616.<br />

54. Abreu MT, Arnold ET, Thomas LS, Gonsky R, Zhou Y, Hu B, et<br />

al. TLR4 and MD-2 expression is regulated by immune-mediated<br />

signals in human intestinal epith<strong>el</strong>ial c<strong>el</strong>ls. J Biol Chem 2002; 277:<br />

20431-20437.<br />

55. Ortega-Cava CF, Ishihara S, Rumi MA, Aziz MM, Kazumori H,<br />

Yuki T, et al. Strategic compartmentalization of <strong>Toll</strong>-like receptor<br />

4 in the mouse gut. J Immunol 2003; 170: 3977-3985.<br />

56. Hornef MW, Frisan T, Van<strong>de</strong>walle A, Normark S, Richter-Dahlfors<br />

A. <strong>Toll</strong>-like receptor 4 resi<strong>de</strong>s in the Golgi apparatus and co<strong>lo</strong>calizes<br />

with internalized lipopolysacchari<strong>de</strong> in intestinal epith<strong>el</strong>ial c<strong>el</strong>ls.<br />

J Exp Med 2002; 195: 559-570.<br />

57. Arron JR, Choi Y. Bone versus immune system. Nature 2000; 408:<br />

535-536.<br />

58. Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and<br />

activation. Nature 2003; 423: 337-342.<br />

59. Nair SP, Meghji S, Wilson M, Reddi K, White P, Hen<strong>de</strong>rson B.<br />

Bacterially induced bone <strong>de</strong>struction: mechanisms and<br />

misconceptions. Infect Immun 1996; 64: 2371-2380.<br />

60. Asai Y, Hirokawa Y, Niwa K, Ogawa T. Osteoclast differentiation<br />

by human osteoblastic c<strong>el</strong>l line SaOS-2 primed with bacterial lipid<br />

A. FEMS Immunol Med Microbiol 2003; 38: 71-79.<br />

61. Bi Y, Seabold JM, Kaar SG, Ragab AA, Golberg VM, Andreson<br />

JM, et al. Adherent endotoxin on orthopedic wear particles stimulates<br />

cytokine production and osteoclast differentiation. J Bone Miner<br />

Res 2001; 16: 2082-2091.<br />

62. Gasper NA, Petty CC, Schrum LW, Marriott I, Bost KL. Bacteriuminduced<br />

CXCL10 secretion by osteoblasts can be mediated in<br />

part through toll-like receptor 4. Infect Immun 2002; 70: 4075-<br />

4082.<br />

63. Kondo A, Koshihara Y, Togari A. Signal transduction system for<br />

interleukin-6 synthesis stimulated by lipopolysacchari<strong>de</strong> in human<br />

osteoblasts. J Interferon Cytokine Res 2001; 21: 943-950.<br />

64. Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya<br />

T, Kobayashi Y, et al. MyD88 but not TRIF is essential for<br />

osteoclastogenesis induced by lipopolysacchari<strong>de</strong>, diacyl lipopepti<strong>de</strong>,<br />

and IL-1alpha. J Exp Med 2004; 200: 601-611.<br />

65. Lacroix S, Feinstein D, Rivest S. The bacterial endotoxin<br />

lipopolysacchari<strong>de</strong> has the ability to target the brain in upregulating<br />

its membrane CD14 receptor within specific c<strong>el</strong>lular populations.<br />

Brain Pathol 1998; 8: 625-640.<br />

66. Laflamme N, Rivest S. <strong>Toll</strong>-like receptor 4: the missing link of the<br />

cerebral innate immune response triggered by circulating gramnegative<br />

bacterial c<strong>el</strong>l wall components. FASEB J 2001; 15: 155-<br />

163.<br />

67. Laflamme N, Soucy G, Rivest S. Circulating c<strong>el</strong>l wall components<br />

<strong>de</strong>rived from gram-negative, not gram-positive, bacteria cause a<br />

profound induction of the gene-encoding <strong>Toll</strong>-like receptor 2 in<br />

the CNS. J Neurochem 2001; 79: 648-657.<br />

68. Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of<br />

<strong>Toll</strong>-like receptors in the human central nervous system. J Neuropathol<br />

Exp Neurol 2002; 61: 1013-1021.<br />

69. Netea MG, Kullberg BJ, Van <strong>de</strong>r Meer JW. Circulating cytokines<br />

as mediators of fever. Clin Infect Dis 2000; 31(Suppl 5): S178-S184.<br />

70. Brochu S, Olivier M, Rivest S. Neuronal activity and transcription<br />

of proinflammatory cytokines, IkappaBalpha, and iNOS in the<br />

mouse brain during acute endotoxemia and chronic infection with<br />

Trypanosoma brucei brucei. J Neurosci Res 1999; 57: 801-816.<br />

71. Nguyen MD, Julien JP, Rivest S. Innate immunity: the missing<br />

link in neuroprotection and neuro<strong>de</strong>generation? Nat Rev Neurosci<br />

2002; 3: 216-227.<br />

72. Dantzer R, Wollman EE. [R<strong>el</strong>ationships between the brain and<br />

the immune system]. J Soc Biol 2003; 197: 81-88.<br />

73. Ohashi K, Burkart V, F<strong>lo</strong>he S, Kolb H. Cutting edge: heat shock<br />

protein 60 is a putative endogenous ligand of the toll-like receptor-<br />

4 complex. J Immunol 2000; 164: 558-561.<br />

74. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning<br />

CJ, Hacker H, et al. Endocytosed HSP60s use toll-like receptor<br />

2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor<br />

signaling pathway in innate immune c<strong>el</strong>ls. J Biol Chem 2001;<br />

276: 31332-31339.<br />

75. Habich C, Baumgart K, Kolb H, Burkart V. The receptor for heat<br />

shock protein 60 on macrophages is saturable, specific, and distinct<br />

from receptors for other heat shock proteins. J Immunol 2002; 168:<br />

569-576.<br />

76. Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Iss<strong>el</strong>s<br />

RD, Wagner H. HSP70 as endogenous stimulus of the <strong>Toll</strong>/<br />

interleukin-1 receptor signal pathway. J Biol Chem 2002; 277:<br />

15107-15112.<br />

77. Tay<strong>lo</strong>r KR, Trowbridge JM, Rudisill JA, Termeer CC, Simon JC,<br />

Gal<strong>lo</strong> RL. Hyaluronan fragments stimulate endoth<strong>el</strong>ial recognition<br />

of injury through TLR4. J Biol Chem 2004; 279: 17079-17084.<br />

78. Guil<strong>lo</strong>t L, Bal<strong>lo</strong>y V, McCormack FX, Golenbock DT, Chignard M,<br />

Si-Tahar M. Cutting edge: the immunostimulatory activity of the<br />

lung surfactant protein-A involves <strong>Toll</strong>-like receptor 4. J Immunol<br />

2002; 168: 5989-5992.<br />

129

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!