Fisiopatología 57 Elevated serum level of anti-müllerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest. J Clin Endocrinol Metab. 2003 Dec;88(12):5957-62. 55 Lockwood GM. The role of inhibin in polycystic ovary syndrome. Hum Fertil (Camb). 2000;3(2):86-92. 56 Welt CK, Taylor AE, Martin KA, Hall JE. Serum inhibin B in polycystic ovary syndrome: regulation by insulin and luteinizing hormone. J Clin Endocrinol Metab. 2002 Dec;87(12):5559-65. 57 Kokcu A, Turhan E, Cetinkaya MB, Yanik F, Alper T, Malatyalioglu E. Inhibin B on cycle day 3 to predict the ovulatory response in women with PCOS undergoing ovulation induction via low dose step-up gonadotropin protocol. Arch Gynecol Obstet. 2004 Dec;270(4): 255-9. 58 Willis D, Franks S. Insulin action in human granulose cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin-like growth factor receptor. J Clin Endocrinol Metab. 1995 Dec;80(12): 3788-90. 59 Barbieri RL, Smith S, Ryan KJ. The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. Fertill Steril. 1988;50:197-212. 60 Dorn C, Muoillet JF, Yan X, Ou Q, Sadovsky Y. Insulin enhances the transcription of luteinizing hormone-beta gene. Am J Obstet Gynecol. 2004 Jul; 191(1):132-7. 61 Rice S, Christoforidis N, Gadd C, Nikolaou D, Seyani L, Donaldson A, et al. Impaired insulin-dependent glucose metabolism in granulose-lutein cells from anovulatory women with polycystic ovaries. Hum Reprod. 2005 Feb; 20(2):373-81. 62 Yan Z, Lee GY, Anderson E. Influence of dehydroepiandrosterone on the expression of insulin-like growth factor-1 during cytogenesis in polycystic rat ovaries and in cultured rat granulose cells. Biol Reprod. 1997 Dec;57(6):1509-16. 63 Barreca A, Del Monte P, Ponzani P, Artini PG, Genazzani AR, Minuto F. Intrafollicular insulin-like growth factor- II levels in normally ovulating women and in patients with polycystic ovary syndrome. Fertil Steril. 1996 Apr; 65(4):739-45. 64 Zang LH, Rodríguez H, Ohno S, Miller W. Serine phosphorilation of human P450c17 increases 17,20 lyase activity: Implicartions for adrenarche and the pollycystic ovary syndrome. Proc Natl Acad Sci (USA). 1995;92:10619-23. 65 Gilling-Smith C, Willis DS, Beard RW, Franks S. Hypersecretion of androstendione by isolated theca cells from polycystic ovaries. J Clin Endocrinol Metab. 1994;79:1158-65. 66 Cara JF, Fan J, Azzarello J, Rosenfield RL. Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells. J Clin Invest. 1990;86:560-5. 67 Hoffman D, Klove K, Lobo RA. The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. Fertil Steril. 1984; 42:76-81. 68 Lucky AW, Rosenfield RL, McGuire J, Rudy S, Helke J. Adrenal androgen hyperresponsiveness to ACTH in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche. J Clin Endocrinol Metab. 1986;62: 840-8. 69 Kamel N, Tonyukuk V, Emral R, Corapcioglu D, Bastemir M, Gullu S. Role of ovary and adrenal glands in hyperandrogenemia in patients with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2005 Feb;113(2):115-21. 70 Kowalska I, Kinalski M, Wolczynski S, Straczkowski M, Kinalska I, Szamatowicz M. The influence of obesity on ovarian function. Plasma leptin concentration in women with polycystic
58 Síndrome <strong>del</strong> <strong>Ovario</strong> Poliquístico ovary syndrome. Gynekol Pol. 1999 Jun; 70(6):428-32. 71 Schachter M, Raziel A, Friedler S, Straussburger D, Bern O, Ron-El R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Hum Reprod. 2003 Apr;18(4):721-7.