Sindrome.del.Ovario.Poliquistico
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Aspectos genéticos 41<br />
drome. Clin Endocrinol (Oxf). 1996;44:<br />
85-90.<br />
106<br />
Urbanek M, Du Y, Silander K, et al.<br />
Variation in resistin gene promoter<br />
not associated with polycystic ovary<br />
syndrome. Diabetes. 2003;52:214-7.<br />
107<br />
Oksanen L, Tiitinen A, Kaprio J, Koistinen<br />
HA, Karonen S, Kontula K. No evidence<br />
for mutations of the leptin or<br />
leptin receptor genes in women with<br />
polycystic ovary syndrome. Mol Hum<br />
Reprod. 2000;6:873-6.<br />
108<br />
Heinonen S, Korhonen S, Hippelainen<br />
M, Hiltunen M, Mannermaa A, Saarikoski<br />
S. Apolipoprotein E alleles in women<br />
with polycystic ovary syndrome. Fertil<br />
Steril. 2001;75:878-80.<br />
109<br />
Fernández-Real JM, Ricart W. Insulin<br />
resistance and chronic cardiovascular<br />
inflammatory syndrome. Endocr Rev.<br />
2003;24:278-301.<br />
110<br />
Hotamisligil GS, Arner P, Caro JF,<br />
Atkinson RL, Spiegelman BM. Increased<br />
adipose tissue expression of tumor<br />
necrosis factor-alpha in human obesity<br />
and insulin resistance. J Clin Invest.<br />
1995;95:2409-15.<br />
111<br />
Hotamisligil GS, Arner P, Atkinson RL,<br />
Spiegelman BM. Differential regulation<br />
of the p80 tumor necrosis factor<br />
receptor in human obesity and insulin<br />
resistance. Diabetes. 1997;46:451-5.<br />
112<br />
Bastard JP, Jar<strong>del</strong> C, Bruckert E, et al.<br />
Elevated levels of interleukin 6 are<br />
reduced in serum and subcutaneous<br />
adipose tissue of obese women after<br />
weight loss. J Clin Endocrinol Metab.<br />
2000;85:3338-42.<br />
113<br />
González F, Thusu K, Ab<strong>del</strong>-Rahman<br />
E, Prabhala A, Tomani M, Dandona P.<br />
Elevated serum levels of tumor necrosis<br />
factor alpha in normal-weight women<br />
with polycystic ovary syndrome. Metabolism.<br />
1999;48:437-41.<br />
114<br />
Escobar-Morreale HF, Calvo RM, Sancho<br />
J, San Millán JL. TNF-alpha and hyperandrogenism:<br />
a clinical, biochemical,<br />
and molecular genetic study. J Clin<br />
Endocrinol Metab. 2001;86:3761-7.<br />
115<br />
Sayin NC, Gucer F, Balkanli-Kaplan P,<br />
et al. Elevated serum TNF-alpha levels<br />
in normal-weight women with polycystic<br />
ovaries or the polycystic ovary<br />
syndrome. J Reprod Med. 2003;48:<br />
165-70.<br />
116<br />
Escobar-Morreale HF, Villuendas G,<br />
Botella-Carretero JI, Sancho J, San<br />
Millán JL. Obesity, and not insulin<br />
resistance, is the major determinant of<br />
serum inflammatory cardiovascular risk<br />
markers in pre-menopausal women.<br />
Diabetologia. 2003;46:625-33.<br />
117<br />
Mohlig M, Spranger J, Osterhoff M,<br />
et al. The polycystic ovary syndrome<br />
per se is not associated with increased<br />
chronic inflammation. Eur J Endocrinol.<br />
2004;150:525-32.<br />
118<br />
Spaczynski RZ, Arici A, Duleba AJ.<br />
Tumor necrosis factor-alpha stimulates<br />
proliferation of rat ovarian theca-interstitial<br />
cells. Biol Reprod. 1999;61:993-8.<br />
119<br />
Roby KF, Terranova PF. Effects of tumor<br />
necrosis factor-alpha in vitro on steroidogenesis<br />
of healthy and atretic follicles<br />
of the rat: theca as a target. Endocrinology.<br />
1990;126:2711-8.<br />
120<br />
Kaipia A, Chun SY, Eisenhauer K, Hsueh<br />
AJ. Tumor necrosis factor-alpha and its<br />
second messenger, ceramide, stimulate<br />
apoptosis in cultured ovarian follicles.<br />
Endocrinology. 1996;137:4864-70.<br />
121<br />
Geurts JM, Janssen RG, Van Greevenbroek<br />
MM, et al. Identification of<br />
TNFRSF1B as a novel modifier gene<br />
in familial combined hyperlipidemia.<br />
Hum Mol Genet. 2000;9:2067-74.<br />
122<br />
Glenn CL, Wang WY, Benjafield AV,<br />
Morris BJ. Linkage and association of<br />
tumor necrosis factor receptor 2 locus<br />
with hypertension, hypercholesterolemia<br />
and plasma shed receptor. Hum<br />
Mol Genet. 2000;9:1943-9.<br />
123<br />
Peral B, San Millán JL, Castello R,<br />
Moghetti P, Escobar-Morreale HF. The<br />
methionine 196 arginine polymorphism<br />
in exon 6 of the TNF receptor 2 gene<br />
(TNFRSF1B) is associated with the<br />
polycystic ovary syndrome and hyper-