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Aspectos genéticos 41<br />

drome. Clin Endocrinol (Oxf). 1996;44:<br />

85-90.<br />

106<br />

Urbanek M, Du Y, Silander K, et al.<br />

Variation in resistin gene promoter<br />

not associated with polycystic ovary<br />

syndrome. Diabetes. 2003;52:214-7.<br />

107<br />

Oksanen L, Tiitinen A, Kaprio J, Koistinen<br />

HA, Karonen S, Kontula K. No evidence<br />

for mutations of the leptin or<br />

leptin receptor genes in women with<br />

polycystic ovary syndrome. Mol Hum<br />

Reprod. 2000;6:873-6.<br />

108<br />

Heinonen S, Korhonen S, Hippelainen<br />

M, Hiltunen M, Mannermaa A, Saarikoski<br />

S. Apolipoprotein E alleles in women<br />

with polycystic ovary syndrome. Fertil<br />

Steril. 2001;75:878-80.<br />

109<br />

Fernández-Real JM, Ricart W. Insulin<br />

resistance and chronic cardiovascular<br />

inflammatory syndrome. Endocr Rev.<br />

2003;24:278-301.<br />

110<br />

Hotamisligil GS, Arner P, Caro JF,<br />

Atkinson RL, Spiegelman BM. Increased<br />

adipose tissue expression of tumor<br />

necrosis factor-alpha in human obesity<br />

and insulin resistance. J Clin Invest.<br />

1995;95:2409-15.<br />

111<br />

Hotamisligil GS, Arner P, Atkinson RL,<br />

Spiegelman BM. Differential regulation<br />

of the p80 tumor necrosis factor<br />

receptor in human obesity and insulin<br />

resistance. Diabetes. 1997;46:451-5.<br />

112<br />

Bastard JP, Jar<strong>del</strong> C, Bruckert E, et al.<br />

Elevated levels of interleukin 6 are<br />

reduced in serum and subcutaneous<br />

adipose tissue of obese women after<br />

weight loss. J Clin Endocrinol Metab.<br />

2000;85:3338-42.<br />

113<br />

González F, Thusu K, Ab<strong>del</strong>-Rahman<br />

E, Prabhala A, Tomani M, Dandona P.<br />

Elevated serum levels of tumor necrosis<br />

factor alpha in normal-weight women<br />

with polycystic ovary syndrome. Metabolism.<br />

1999;48:437-41.<br />

114<br />

Escobar-Morreale HF, Calvo RM, Sancho<br />

J, San Millán JL. TNF-alpha and hyperandrogenism:<br />

a clinical, biochemical,<br />

and molecular genetic study. J Clin<br />

Endocrinol Metab. 2001;86:3761-7.<br />

115<br />

Sayin NC, Gucer F, Balkanli-Kaplan P,<br />

et al. Elevated serum TNF-alpha levels<br />

in normal-weight women with polycystic<br />

ovaries or the polycystic ovary<br />

syndrome. J Reprod Med. 2003;48:<br />

165-70.<br />

116<br />

Escobar-Morreale HF, Villuendas G,<br />

Botella-Carretero JI, Sancho J, San<br />

Millán JL. Obesity, and not insulin<br />

resistance, is the major determinant of<br />

serum inflammatory cardiovascular risk<br />

markers in pre-menopausal women.<br />

Diabetologia. 2003;46:625-33.<br />

117<br />

Mohlig M, Spranger J, Osterhoff M,<br />

et al. The polycystic ovary syndrome<br />

per se is not associated with increased<br />

chronic inflammation. Eur J Endocrinol.<br />

2004;150:525-32.<br />

118<br />

Spaczynski RZ, Arici A, Duleba AJ.<br />

Tumor necrosis factor-alpha stimulates<br />

proliferation of rat ovarian theca-interstitial<br />

cells. Biol Reprod. 1999;61:993-8.<br />

119<br />

Roby KF, Terranova PF. Effects of tumor<br />

necrosis factor-alpha in vitro on steroidogenesis<br />

of healthy and atretic follicles<br />

of the rat: theca as a target. Endocrinology.<br />

1990;126:2711-8.<br />

120<br />

Kaipia A, Chun SY, Eisenhauer K, Hsueh<br />

AJ. Tumor necrosis factor-alpha and its<br />

second messenger, ceramide, stimulate<br />

apoptosis in cultured ovarian follicles.<br />

Endocrinology. 1996;137:4864-70.<br />

121<br />

Geurts JM, Janssen RG, Van Greevenbroek<br />

MM, et al. Identification of<br />

TNFRSF1B as a novel modifier gene<br />

in familial combined hyperlipidemia.<br />

Hum Mol Genet. 2000;9:2067-74.<br />

122<br />

Glenn CL, Wang WY, Benjafield AV,<br />

Morris BJ. Linkage and association of<br />

tumor necrosis factor receptor 2 locus<br />

with hypertension, hypercholesterolemia<br />

and plasma shed receptor. Hum<br />

Mol Genet. 2000;9:1943-9.<br />

123<br />

Peral B, San Millán JL, Castello R,<br />

Moghetti P, Escobar-Morreale HF. The<br />

methionine 196 arginine polymorphism<br />

in exon 6 of the TNF receptor 2 gene<br />

(TNFRSF1B) is associated with the<br />

polycystic ovary syndrome and hyper-

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