Paliativos

PO546
Response to palliative radiotherapy in patients with metastatic spinal cord compression
Lourdes De Ingunza Baron 1 , Verónica Díaz Díaz 1 , Esther González Calvo 1 , Isabel Villanego Beltran 1 , Laura
Díaz Gómez 1
1
Servicio de Oncología Radioterápica, Hospital Universitario Puerta del Mar, Cádiz
Introduction: Metastases can lead to significant morbidity and reduction in quality of life due to pain, vertebral
collapse and spinal cord compression (SCC). Between 5% and 20% of patients with spinal metastases develop
metastatic spinal cord compression during the course of their disease. Radiotherapy has been considerate one of the
principal treatment of this emergency. This report examines the response of metastatic spinal cord compression due
radiotherapy or combined therapies.
Methodology: A cohort study was performed involving patients with irradiated MSCC due to cancer diagnosed
between 2010 and 2014. Clinical and socio-demographic data were extracted from our Departament data base.
We studied clinical symptons and response, surgery before radiotherapy (yes/no and tecniche), radiotherapy
fractionation, time of response, re-irradiation and overvall survival. About clinical symptons we made groups: group
0 involves patients only with pain, group 1 involves patients with paresthesia, group 2 involves patients with some
alteration of motor function and those with complete paraplegia called group 3.
Results: A total of 87 patients with incident irradiated MSCC were identified. 7 of the total of patients, were operated
befote radiotherapy. We usually used hipofractionation like 20Gy (5Gy per fraction in 4 days) in 39% of cases. The
second hipofractionation was 8Gy in one fraction (32%). The mean of time of response was 5 months. We did 11
re-irradiations. About 50-100% of pain response was 79% (Group 0), 75% (Group 1), 73% (Group 2), 92% (Group
3). About function motor response in Group 2 was complete in 7% of cases and parcial 40%.
Conclusion: In the management of metastatic spinal cord compression, palliative radiotherapy is important and
necesary to lead a syntomatic response and to have a local control, even if the patient is asyntomatic.
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