Nuevas entidades de Carcinoma de Pene y subtipos de PeIN

mTOR signaling Pathway in Penile Squamous Cell Carcinoma:phosphorilated mTOR, phosphorilated eIF4E and p53 overexpressioncorrelates with aggressive tumors in a Mediterranean population.C. Ferrandiz-Pulido (2), E. Masferre (3), A. Toll (3), Ramon M. Pujol (3), J. Hernandez-Losa(1) , S Ramón y Cajal (1) I. De Torres (1) ), V. Garcia-Patos (2)• 67 cases of primary SCC and 8 caseswith lymph node metastases.J. Urol. 2013 (in press)(A) p53 (-) in invasive SCC (B) p53(+) in metastatic SCC.(C) with the lymph node metastases also p53 (+).(D)pmTOR negative expression (E) pmTOR(+) in metastaticSCC and also their lymph node metastases (F).pMAPK (+)in invasive SCC (G) but negative expression in a metastaticcase (H) and their lymph node metastases