O papel modulador do gene AIRE - capes

opening a new perspective for the discovery of genes participating in T celldifferentiation.Finally, 14 vs 17 days p.c. exhibited eight gene nodes, of which four werechosen for discussion (Fig. 1C).1) The first gene node is represented by the Stxbp3a gene, whichparticipates in intracellular protein traffic and transport. It was negativelyregulated by itself, by the Tacc1 gene and by the transcribed locus (ID640711) and positively regulated the Capicua homolog (Drosophila) gene, Cic(mRNA accession number NM_027882).2) The Cic gene was also identified as a node, which was positivelyregulated by the Stxbp3a and Tacc1 genes and by the transcribed locus (ID640711). This indicates that Cic gene node could play a role in the late phaseof thymus development.3) Another gene node identified was the Transforming acidic coiled-coilcontainingprotein 1 gene, Tacc1 (mRNA accession number NM_177089, ID640235), which is expressed at high levels during early embryogenesis andwhose function is likely involved in the processes that promote cell divisionprior to the formation of differentiated tissues. This gene node was positivelyregulated by four others; the transcribed locus ID 640711 and the Prrg2, Gosr2and Triobp genes, in addition to positive self-regulation. It established negativeregulation with the Stxbp3a gene in both directions (Tacc1 ↔ Stxbp3a) andpositively regulated the Cic gene. Due to its positively regulated profile andbiological function, this gene node represents an important candidate for a rolein thymus/thymocyte development.252