O papel modulador do gene AIRE - capes

MANUSCRITOcontrol of their transcriptional levels, secondly that a gene, such as Gucy2d,may act as additional positive controller upon downstream genes besides Airein the control of PGE.AcknowledgementsThis study received financial support from Fundação de Amparo à Pesquisado Estado de São Paulo (FAPESP grant No. 06/54788-4) and ConselhoNacional de Desenvolvimento Científico e Tecnológico (CNPq). We thank Dr.Catherine Nguyen of the Institut National de la Santé et de la RechercheMédicale (INSERM) of Marseille, France for the cDNA clones used in thepreparation of the microarrays.ReferencesKyewski B, Derbinski J (2004). Self-representation in the thymus: an extendedview. Nat Rev Immunol 4, 688-698.Klein L, Kyewski B (2000). Self-antigen presentation by thymic stromal cells: asubtle division of labor. Curr Opin Immunol. 12(2):179-86.Anderson G, Lane PJL, Jenkinson EJ (2007). Generating intrathymicmicroenvironments to establish T‐cell tolerance. Nat. Rev. Immunol.7(12): 954-63.Jolicoeur C, Hanahan D, Smith KM (1994). T-cell tolerance toward a transgenic-cell antigen and transcription of endogenous pancreatic genes inthymus. Proc. Natl Acad. Sci. USA 91, 6707–6711.Derbinski J, Schulte A, Kyewski B, Klein L (2001). Promiscuous geneexpression in medullary thymic epithelial cells mirrors the peripheral self.Nature Immunology 2: 1032-1039.Gotter J, Brors B, Hergenhahn M, Kyewski B (2004). Medullary epithelial cellsof the human thymus express a highly diverse selection of tissue-specificgenes co-localized in chromosomal clusters. J. Exp. Med. 199(2): 155–166.Alferink J, Aigner S, Reibke R, Hämmerling GJ, Arnold B (1999). Peripheral Tcell tolerance: the contribution of permissive T cell migration intoparenchymal tissues of the neonate. Immunol. Rev. 169, 255–261.Walker LS, Abbas AK (2002). The enemy within: keeping self-reactive T cells atbay in the periphery. Nature Rev. Immunol. 2, 11–19.216