O papel modulador do gene AIRE - capes

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ANEXO IIEST IMAGE:576142 Expressed sequence tag 0.9321476 8.095769Mre11a IMAGE:639936 Meiotic recombination 11 homolog A (S. cerevisiae) 0.8711923 8.0344376820402O20Rik IMAGE:640923 RNA binding motif protein 39 0.86235416 8.587415Cybb IMAGE:583187 Cytochrome b-245, beta polypeptide 0.89804614 8.762344Rbl2 IMAGE:576225 Retinoblastoma-like 2 0.918051 8.762344Cd83 IMAGE:574651 CD83 antigen 0.89952916 9.1921625EST IMAGE:641087 Expressed sequence tag 0.9061627 9.1921625Hel308 IMAGE:581959 Helicase, mus308-like (Drosophila) 0.90254235 9.1921625Klhl20 IMAGE:582908 Kelch-like 20 (Drosophila) 0.9313501 9.724821EST IMAGE:582322 Expressed sequence tag 0.9115154 9.724821Atpaf1 IMAGE:639636 ATP synthase mitochondrial F1 complex assembly factor 1 0.9414004 9.724821Park7 IMAGE:583034 Parkinson disease (autosomal recessive, early onset) 7 0.9238755 9.724821RhoaIMAGE:572818CDNA, clone:Y0G0104B14, strand:minus, reference:ENSEMBL:Mouse-Transcript-NST:ENSMUST00000007959, based on BLATsearch 0.896466 9.724821Transcribed locus IMAGE:575780 Chemokine (C-C motif) ligand 25 0.93027353 10.575243IMAGE:136223EST2 Expressed sequence tag 0.9037807 10.943718C730042F17Rik IMAGE:640700 ORM1-like 1 (S. cerevisiae) 0.8992265 10.909013In multipleclusters IMAGE:573267 RPA interacting protein 0.9084455 10.909013Dbp IMAGE:583416 D site albumin promoter binding protein 0.9236056 10.909013Actr1a IMAGE:583567 ARP1 actin-related protein 1 homolog A (yeast) 0.90226614 10.909013Dnajc7 IMAGE:573602 DnaJ (Hsp40) homolog, subfamily C, member 7 0.8710109 10.909013Nlk IMAGE:582998 Nemo like kinase 0.9272456 11.317518Ddx3x IMAGE:639697 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked 0.9183363 12.837532Elk4 IMAGE:583566 ELK4, member of ETS oncogene family 0.8972935 12.987931EST IMAGE:583908 Expressed sequence tag 0.8932793 12.987931193
ANEXO IIEST IMAGE:576476 Expressed sequence tag 0.9310019 12.987931Gucy2d IMAGE:582819 Guanylate cyclase 2d 0.9221744 12.987931Ncf4 IMAGE:576061 Neutrophil cytosolic factor 4 0.9115133 14.5946665Pot1 IMAGE:640128 Protection of telomeres 1A 0.92453456 14.5946665Btbd1 IMAGE:582942 BTB (POZ) domain containing 1 0.9308438 14.5946665E130112N10Rik IMAGE:640155 CD antigen 27 0.8934426 14.5946665EST IMAGE:641158 Expressed sequence tag 0.8800882 14.5946665EST IMAGE:576500 Expressed sequence tag 0.94008034 14.5946665Slc22a7 IMAGE:574190 Solute carrier family 22 (organic anion transporter), member 7 0.9212938 14.5946665EST IMAGE:583342 Expressed sequence tag 0.9084793 14.5946665Sh3gl1 IMAGE:582991 SH3-domain GRB2-like 1 0.90447086 14.5946665Ier5 IMAGE:574793 Immediate early response 5 0.9171551 14.5946665EST IMAGE:640956 Expressed sequence tag 0.8923168 14.5946665EST IMAGE:640851 Expressed sequence tag 0.9186528 14.5946665EST IMAGE:583661 Expressed sequence tag 0.9314311 14.5946665Brpf1 IMAGE:640234 Bromodomain and PHD finger containing, 1 0.93281096 14.5946665Hexb IMAGE:575852 Hexosaminidase B 0.9403777 14.5946665194
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Universidade de São PauloFaculdade
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Macedo, ClaudiaO papel modulador do
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Dedico Especialmente este TrabalhoM
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AgradecimentosAgradeço do fundo do
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ÍndiceRESUMO .....................
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INDICE DE FIGURASFigura 1. Desenvol
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Promiscuous gene expression in medu
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INTRODUÇÃO1. INTRODUÇÃO1.1. A m
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INTRODUÇÃORecentemente surgiram e
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INTRODUÇÃOmigram para a região s
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INTRODUÇÃOCD4 + CD8 + , e Ccl21 (
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INTRODUÇÃOos timócitos duplo-pos
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INTRODUÇÃOgrande diversidade nas
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INTRODUÇÃOAs células mTECs são
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INTRODUÇÃODerbinski (2004). Os ti
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INTRODUÇÃOinvertebrados multicelu
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INTRODUÇÃOCoraçãoLínguaEstôma
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INTRODUÇÃO1.3. O papel do gene Au
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INTRODUÇÃOdefinido pela atividade
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INTRODUÇÃOpara abordarmos nossa p
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INTRODUÇÃOesses modelos levam em
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Hipóteses
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Objetivos
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Material e Métodos
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MATERIAL E MÉTODOSFigura 6. Padrã
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MATERIAL E MÉTODOScom estes RNAs f
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MATERIAL E MÉTODOSdos complexos de
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MATERIAL E MÉTODOSAo RNA total rec
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4.5. PCRs semi-quantitativas para o
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MATERIAL E MÉTODOSminutos a 4 °C.
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MATERIAL E MÉTODOS(Merck), soluç
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MATERIAL E MÉTODOSEnsaios de co-hi
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MATERIAL E MÉTODOSRNA TotalANELAME
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MATERIAL E MÉTODOSa) Preparação
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MATERIAL E MÉTODOScentrifugação
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MATERIAL E MÉTODOScanais (Cy3 e Cy
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MATERIAL E MÉTODOSSpotfinderQuanti
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MATERIAL E MÉTODOSOnde Xp(i) e Xc(
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MATERIAL E MÉTODOSO programa SAM p
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MATERIAL E MÉTODOSextrair automati
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DELINEAMENTO EXPERIMENTAL5. DELINEA
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RESULTADOS6. RESULTADOS6.1. Inibiç
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RESULTADOSPCR semiquantitativa gene
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RESULTADOS6.3. RT-PCRs semi-quantit
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RESULTADOS11.00%6,50%AdequadaNão A
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RESULTADOS6.6. Quantificação e no
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RESULTADOSPara um melhor entendimen
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RESULTADOSFigura 25. Agrupamento hi
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RESULTADOSFigura 26. Gráfico ilust
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RESULTADOS6.8. Influência do silen
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Discussão
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DISCUSSÃOA tolerância do repertó
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DISCUSSÃOCom relação à técnica
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DISCUSSÃOgene AIRE (do inglês aut
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DISCUSSÃOdesse modo a tolerância
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DISCUSSÃOPML (leucemia promielocit
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DISCUSSÃOBoehm et al. (2003) afirm
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DISCUSSÃOprograma Genenetwork (Wu
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Conclusões
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Referências Bibliográficas
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REFERÊNCIAS BIBLIOGRÁFICASBarthlo
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REFERÊNCIAS BIBLIOGRÁFICASDissert
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REFERÊNCIAS BIBLIOGRÁFICASGotter
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REFERÊNCIAS BIBLIOGRÁFICASMatsumo
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REFERÊNCIAS BIBLIOGRÁFICASby mito
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REFERÊNCIAS BIBLIOGRÁFICASRossi S
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REFERÊNCIAS BIBLIOGRÁFICASof thym
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Anexo I123
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ANEXO IEST IMAGE:582370 Expressed s
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ANEXO IDhps IMAGE:583332 Deoxyhypus
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ANEXO IMapkapk2 IMAGE:572979 MAP ki
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ANEXO IGm608 IMAGE:583350 Gene mode
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ANEXO ICcdc72 IMAGE:640628 Coiled-c
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ANEXO ITranscribed locusTranscribed
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ANEXO IEST IMAGE:583221 Expressed s
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ANEXO ITranscribed locusTranscribed
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ANEXO Irepair deficiency, complemen
Page 158 and 159: ANEXO Imember 1EST IMAGE:583824 Exp
Page 160 and 161: ANEXO ITranscribed locus IMAGE:5830
Page 162 and 163: ANEXO ITfdp1 IMAGE:640119 Transcrib
Page 164 and 165: ANEXO IEST IMAGE:583902 Expressed s
Page 166 and 167: ANEXO I2410022M11Rik IMAGE:640727 R
Page 168 and 169: ANEXO Icontaining 1Kif14 IMAGE:5836
Page 170 and 171: ANEXO Imember 3In multiple clusters
Page 174 and 175: ANEXO IAnkrd10 IMAGE:583740 Ankyrin
Page 178 and 179: ANEXO IVcam1 IMAGE:576563 Vascular
Page 180 and 181: ANEXO ITegt IMAGE:639877 Testis enh
Page 182 and 183: ANEXO I3Ehmt2Euchromatic histone ly
Page 188 and 189: ANEXO I20 homolog (yeast)Ube1c IMAG
Page 190 and 191: ANEXO IRasa3 IMAGE:582174 RAS p21 p
Page 194 and 195: ANEXO I4930566A11Rik IMAGE:583433 R
Page 200 and 201: Anexo II
Page 202 and 203: ANEXO II1500002B03RikIMAGE:1330385
Page 204 and 205: ANEXO IIEST IMAGE:640173 Expressed
Page 206 and 207: ANEXO IICnot10 IMAGE:576406 CCR4-NO
Page 210 and 211: Anexo III
Page 212 and 213: ANEXO III197Ifit1RelaIMAGE:575632Gr
Page 214 and 215: ANEXO III199Nde1Nol5aIMAGE:640341Rp
Page 216 and 217: Manuscrito da Tese
Page 218 and 219: MANUSCRITOAbstractThe expression of
Page 220 and 221: MANUSCRITOdominated the scenario in
Page 222 and 223: MANUSCRITOserum autoantibodies, all
Page 224 and 225: MANUSCRITOwere transfected with 10
Page 226 and 227: MANUSCRITOwere analyzed using the M
Page 228 and 229: MANUSCRITOpurified from ex vivo mou
Page 230 and 231: MANUSCRITOinformation theory as ARA
Page 232 and 233: MANUSCRITOKyewski B, Derbinski J, G
Page 234 and 235: MANUSCRITOBruno R, Sabater L, Tolos
Page 236 and 237: MANUSCRITOFigure 3. The gene expres
Page 238 and 239: MANUSCRITOABFigure 5. Genetics netw
Page 240 and 241: SÚMULACURRICULUM VITAE (Janeiro 20
Page 242 and 243: ESTÁGIO NO EXTERIORSÚMULA• Labo
Page 244 and 245: SÚMULAtranscript finishing initiat
Page 246 and 247: SÚMULAlinhagens isogênicas de cam
Page 248 and 249: SÚMULABOLSAS DE ESTUDO• Bolsa de
Page 250 and 251: T cell signaling gene networks duri
Page 252 and 253: IntroductionThe thymus is an import
Page 254 and 255: ontogeny using such technology has
Page 256 and 257: laboratory using a Generation III A
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cDNA microarray data analysisStatis
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Gene networksAs previously mentione
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cells, including human herpesvirus-
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gene was mostly indirectly positive
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lymphocytes and finally associates
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4) Finally, Prrg2 was also identifi
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14. Kishimoto H, Sprent J (2000) Th
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proliferation of a rat astrocyte ce
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IMMUNOLOGYORIGINAL ARTICLEOnset of
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Promiscuous gene expression in muri
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R.S. Cardoso et al. / Molecular Imm
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Molecular Immunology 42 (2005) 1043
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D.A.R. Magalhães et al. / Molecula
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D.A.R. Magalhães et al. / Molecula
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Molecular and Cellular Biochemistry
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225Table 1. Target cDNA sequences a
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227coincided (CBA/J) with expressio
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