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O papel modulador do gene AIRE - capes

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REFERÊNCIAS BIBLIOGRÁFICASMatsumoto M (2005). Development of autoimmunity againsttranscriptionally unrepressed target antigen in the thymus of Airedeficientmice. J. Immunol. 174, 18621870 (2005).Kyewski B, Derbinski J, Gotter J, Klein L (2002). Promiscuous <strong>gene</strong> expressionand central T-cell tolerance : more than meets the eye. Trends Immunol.23: 364Kyewski B, Derbinski J (2004). Self-representation in the thymus: an extendedview. Nat Rev Immunol 4, 688-698.Kyewski B, Klein L (2006). A central role for central tolerance. Annu. Rev.Immunol. 24: 571-606.Leonard, M. (1946). Chronic idiopathic hypoparathyroidism with superimposedAddison’s disease in a child. J. Clin. En<strong>do</strong>crinol. Metab. 6, 493–495Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC (2003). Aire regulatesnegative selection of organ-specific T cells. Nature Immunology 4(4):350-4.Liston A, Gray DHD, Lesage S, Fletcher AL, Wilson J, Webster KE, Scott HS,Boyd RL, Peltonen L, Goodnow CC (2004). Gene Dosage–limiting Role ofAire in Thymic Expression, Clonal Deletion, and Organ-specificAutoimmunity. J. Exp. Med. 200 (8): 1015-1026.Liiv I, Rebane A, Org T, Saare M, Maslovskaja J, Kisand K, Juronen E, Valmu L,Bottomley MJ, Kalkkinen N, Peterson P (2007). DNA-PK contributes to thephosphorylation of <strong>AIRE</strong>: Importance in transcriptional activity.Biochimica et Biophysica Acta 1783(1):74-83.Lind EF, Prockop SE, Porritt HE, Petrie HT (2001). Mapping precursormovement through the postnatal thymus reveals specificmicroenvironments supporting defined stages of early lymphoiddevelopment. J. Exp. Med. 194, 127–134.Magalhães DA, Silveira EL, Junta CM, Sandrin-Garcia P, Fachin AL, DonadiEA, Sakamoto-Hojo ET, Passos GA (2006). Promiscuous <strong>gene</strong> expression inthe thymus: the root of central tolerance. Clin Dev Immunol.13(2-4):81-99.115

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