[REV. MED. CLIN. CONDES - <strong>2013</strong>; <strong>24</strong>(1) 131-138]neurólogo, y al médico intensivista entre otros, quienes definirán el tipode tratamiento que requiere cada paciente.La terapia endovascular también tiene un rol en tratamiento del vasoespasmocerebral síntomatico secundario a HSAa (Figura 3). El vasoespasmocerebral es más frecuente entre el 7 a 10 día de la hemorragiay resuelve espontáneamente después de los 21 días. Algunas delas recomendaciones publicadas en las recientes guías de la SociedadAmericana de Stroke (39) en relación a la terapia del vasoespasmo síntomaticoincluyen:• EL Doppler Transcraneal es un método diagnóstico razonable para ladetección precoz del vasoespasmo cerebral.• La inducción de hipertensión arterial es recomendable en el pacientescon vasoespasmo cerebral sintomático si su estado cardíaco no locontraindique.• La terapia endovascular con angioplastia cerebral y/o la infusión demedicamentos vasodilatador superselectiva intra-arterial intra-cerebraltambién es razonable en pacientes con vasoespasmo cerebral sintomático,particularmente sino responde a una terapia antihipertensiva.SÍNTESISLa alternativa de terapia neuroendovascular para el tratamiento del accidentevascular encefálico agudo es una área de la medicina en rápidaexpansión. El rescate endovascular del infarto cerebral agudo tienecomo principal objetivo la rápida reperfusión del vaso ocluido utilizandola trombolisis intra-arterial cerebral y distintos métodos de trombectomíamecánica o colocación permanente de neurostent. El tratamientoneuro-endovascular de la hemorragia subaracnoidea aguda aneurismáticatambién se ha establecido como la terapia de elección e incluyela embolización convencional con coils del aneurisma cerebral roto outilizando técnica de embolización balón o stent asistido o colocaciónprimaria de stent con tecnología de divertidor de flujo. Además, conla terapia endovascular se puede efectuar angioplastía farmacológica ymecánica del vasoespasmo cerebral.abFigura 3. Angioplastia cerebral del vasoespasmo por hemorragia subaracnoidea. (a) Angiografia cerebral digital carotidea izquierda muestra un severo vasoespasmode arteria cerebral media y cerebral posterior izquierda. (b) Angiografia cerebral luego de angioplastia cerebral farmacológica con Milrinona intra-arterial y angioplastiamecánica muestra un significativa mejoría en el calibre del los vasos de esta circulación.136
[TRATAMIENTO ENDOVASCULAR DEL ACCIDENTE VASCULAR ENCEFÁLICO AGUDO - DR. FRANCISCO MENA G.]REFERENCIAS BIBLIOGRáFICAS1. Instituto Nacional de Estadísticas, (INE). Chile: anuario de estadísticasvitales, 2003. http://www.ine.cl.2. Lavados PM, Sacks C, Prina L, et al. Incidence, case-fatality rate, and prognosisof ischaemic stroke subtypes in a predominantly Hispanic-Mestizo population inIquique Chile (PISCIS Project): a community-based incidente study. The LancetNeurology 2007;6(2):140-148.3. The National Institute of Neurological Disorders and Stroke rt-PA StrokeStudy Group. Tissue plasminógeno activator for acute ischemic stroke. N EnglJ Med 1995;333:1581-1587.4. Mirski MA, Chang CW, Cowan R. Impact of a neuroscience intensive careunit on neurosurgical patient outcomes and cost of care: Evidence-basedsupport for an intensivist-directed specialty ICU model of care. J NeurosurgAnesthesiol 2001;13:83-92.5. The National Institute of Neurological Disorders and Stroke rt-PA StrokeStudy Group. Tissue plasminogen activator for acute ischemic stroke. N Engl JMed 1995;333:1581-1587.6. Hacke W, Kaste M, Bluhmki E et al. Thrombolysis with alteplase 3 to 4.5hours after acute ischemic stroke. N Engl J Med 2008;359(13):1317-29.7. Wahlgren N, Ahmed N, Davalos A, et al. Thrombolysis with alteplase 3-4.5h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet2008;372(9646):1303-9.8. Del Zoppo GJ, Higashida RT, Furlan AJ, et al. PROACT: a phase II randomizedtrial of recombinant pro-urokinase by direct arterial delivery in acute middlecerebral artery stroke. PROACT Investigators. Prolyse in Acute CerebralThromboembolism. Stroke 1998;29(1):4-11.9. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acuteischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse inAcute Cerebral Thromboembolism. JAMA 1999;282(21):2003-11.10. IMS Study Investigators. Combined intravenous and intra-arterialrecanalization for acute ischemic stroke. The interventional Management ofstroke study. Stroke 2004;35:904-911.11. IMS II Trial Investigators. The interventional management of stroke (IMS) IIstudy. Stroke 2007;38(7):2127-35.12. Baker WL, Colby JA, Tongbram V, et al. Neurothrombectomy devices forthe treatment of acute ischemic stroke: State of the evidence. Ann Intern Med2011;154:<strong>24</strong>3-252.13. Lewandowski C, Frankel M, Tomsick T, et al. Combined intravenousand intra-arterial r-TPA versus intra-arterial therapy of acute ischemic strokeemergency Management of stroke (EMS) bridging trial. Stroke 1999;30:2598-2605.14. Adams Jr HP, del Zoppo G, Alberts MJ, et al. Guidelines for the earlyManagement of adults with ischemic stroke: a guideline from the AmericanHeart Association/American Stroke Association stroke council, clinicalcardiology council, cardiovascular radiology and interventional council, andthe atherosclerotic peripheral vascular disease and quality of care outcomes inresearch interdisciplinary working groups: The American Academy of Neurologyaffirms the value of this guideline as a educational tool for neurologists. Stroke2007;38:1655-1711.15. Gobin YP, Starkman S, Duckwiler GR, et al. MERCI 1: a phase I study ofMechanical Embolus Removal in Cerebral Ischemia. Stroke 2004;35(12):2848-54.16. Smith WS, Sung G, Saber J, et al. Mechanical thrombectomy for acuteischemic stroke: final results of the Multi MERCI trial. Stroke 2008;39:1205-12.17. Bose A, Henkes H, Alfke K, et al. The Penumbra System: a mechanicaldevice for the treatment of acute stroke due to thromboembolism. AJNR Am JNeuroradiol 2008;29(7):1409-13.18. Kelly ME, Furlan AJ, Fiorella D. Recanalization of an acute middle cerebralartery occlusion using a self expanding, reconstrainable, intracraneal microstentas a temporary endovascular bypass. Stroke 2008;39(6):1770-3.19. Levy EI, Siddiqui AH, Crumlish A, et al. First Food and Drug Administrationapprovedprospective trial of primary intracraneal stenting for acute stroke SARIS(stent-assisted recanalization in acute ischemic stroke). Stroke 2009;40:3552-6.20. Clinical Trials. Gov:Solitaire Fr with the Intention for Thrombectomy (SWIFT)Study. ClinicalTrials.Gov, 2009.21. ClinicalTrials.Gov: Randomized Trial Evaluating Performance of theTrevo Retriever Versus the Merci Retriever in Acute Ischemic Stroke (Trevo2).ClinicalTrials.Gov, 2011.22. Rubiera, M et al. Bridging intravenous intra-arterial rescue strategyincreases recanalizationa and the likelihood of a good outcome in nonresponderintravenous tissue plasminogen activator-treated patientes: a case-controlstudy. Stroke 2011;42:993-997.23. Nichols C et al. Is peri-procedural sedation Turing acute stroke therapyassociated with poorer functional outcomes? J Neurointerv Surg 2010;2:67-70.<strong>24</strong>. Khatri P, et al for the Interventional Management of Stroke III Investigators.Methodology of the Interventional Management of Stroke III Trial. Int. J. Stroke2008;3:130-137.25. Josephson SA, Saber JL, Smith WS. Comparison of mechanical embolectomyand intraarterial thrombolysis in acute ischemic stroke within the MCA: MERCIand Multi MERCI compared to PROACT II. Neurocrit Care 2009;10(1):43-9.26. Yoo AJ, Chaudhry ZA, Thabele M, et al. Endovascular treatment of acuteischemic stroke: Tech Vasc Interventional Rad 2012;15:33-40.27. Hakimelahi R, Romero J, Nogueira RG, et al. Final infarct <strong>vol</strong>umen is thebest predictor of outcome in large Wessel occlusion patients treated with IAT.Annual Meeting of American Society of Neuroradiology Vancouver, BritishColumbia, Canada, 2009.28. Yoo AJ, Verduzco IA, Schaefer PW, et al. MRI-based selection for intraarterialstroke therapy: Value of pretreatment difusión-weighted imaging lesion<strong>vol</strong>umen in selecting patients with acute stroke who will benefit from earyrecanalization. Stroke 2009;40:2046-2054.29. Lee KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenousalteplase and outcome in stroke: An updated pooled análisis of ECASS, Atlantis,NINDS, and EPITHET trials. Lancet 2010;375:1695-1703.30. Katzan IL, Hammer MD, Furland AJ, et al. Quality improvement and tissuetypeplasminogen activator for acute ischemic stroke: A Cleveland update.Stroke 2003;34:799-800.31. Mazighi M, Labreuche J, Meseguer E, et al. Impact of a combined intravenous/ intra-arterial approach in octogenarians. Cerebrovasc Disc 2011;31:559-565.137