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Editorialción considerables) entre los estudios genéticosy de marcadores biológicos y los estudioslongitudinales de carácter clínico y fenomenológico.Estos dos paradigmas compiten porfondos pero no son (o no deberían ser considerados)mutuamente excluyentes. Quizás elmayor financiamiento que reciben los estudiosgenéticos y de marcadores biológicos se debaa la fascinación por las tecnologías avanzadasen las sociedades del siglo XXI.REFERENCIASBeesdo K., Lau J.Y., Guyer A.E., McClure-Tone E.B., Monk C.S., Nelson E.E., FrommS.J., Goldwin M.A., Wittchen H.-U., LeibenluftE., Ernst M., Pine D.S. Common anddistinct amygdala-function perturbations indepressed vs anxious adolescents. Archivesof General Psychiatry. 2009, 66:275-285.Biederman J., Faraone S.V., Wozniak J., MickE., Kwon A., Aleardi M. Further evidence ofunique developmental phenotypic correlatesof pediatric bipolar disorder: findings from alarge sample of clinically referred preadolescentchildren assessed over the last 7 years.Journal of Affective Disorders 82 Suppl.2004, 1:S45-58.Blader J.C., Carlson G.A. Increased rates of bipolardisorder diagnoses among U.S. child,adolescent, and adult inpatients, 1996-2004.Biological Psychiatry. 2007, 62:107-14.Brotman M.A., Schmajuk M., Rich B.A., DicksteinD.P., Guyer A.E., Costello E., EggerH.L., Angold A., Pine D.S., Leibenluft E.Prevalence, Clinical Correlates, and LongitudinalCourse of Severe Mood Dysregulationin Children. Biological Psychiatry. 2006,60:991-997.Brotman M.A., Kassem L., Reising M.M., GuyerA.E., Dickstein D.P., Rich B.A., TowbinK.E., Pine D.S., McMahon F.J., LeibenluftE. Parental diagnoses in youth with narrowRev. Chil. Psiquiatr. Neurol. Infanc. Adolesc.Agosto 2011phenotype bipolar disorder or severe mooddysregulation. The American Journal of Psychiatry.2007, 164:1238-1241.Brotman M.A., Rich B.A., Guyer A.E., LunsfordJ.R., Horsey S.E., Reising M.M., ThomasL.A., Fromm S.J., Towbin K., Pine D.S.,Leibenluft E. Amygdala activation duringemotion processing of neutral faces in childrenwith severe mood dysregulation versusADHD or bipolar disorder. The AmericanJournal of Psychiatry. 2010,167:61-69.Fristad M.A., Verducci J.S., Walters K., YoungM.E. Impact of multifamily psychoeducationalpsychotherapy in treating children aged 8to 12 years with mood disorders. Archives ofGeneral Psychiatry. 2009, 66:1013-1020.Leibenluft E. Severe mood dysregulation, irritability,and the diagnostic boundaries ofbipolar disorder in youths. American Journalof Psychiatry. 2011, 168:129-42.Papolos D., Mattis S., Golshan S., Molay F.Fear of harm, a possible phenotype of pediatricbipolar disorder: A dimensional approachto diagnosis for genotyping psychiatricsyndromes. Journal of AffectiveDisorders. 2009, 118:28-38.Stringaris A., Cohen P., Pine D.S., LeibenluftE. Adult outcomes of youth irritability: A 20-year prospective community-based study.The American Journal of Psychiatry. 2009,166:1048-1054.Stringaris A., Baroni A., Haimm C., BrotmanM., Lowe C.H., Myers F., Rustgi E., WheelerW., Kayser R., Towbin K., Leibenluft E. Pediatricbipolar disorder versus severe mooddysregulation: Risk for manic episodes onfollow-up. Journal of the American Academyof Child & Adolescent Psychiatry. 2010,49:397-405.West A.E., Pavuluri M.N. Psychosocial treatmentsfor childhood and adolescent bipolardisorder. Child and Adolescent PsychiatricClinics of North America. 2009, 18:471-482.118