Epilepsia vascular - Grupo de Epilepsia de la SEN

J. Á. Mauri Llerda, C. Tejero Juste
tantes para el desarrollo de epilepsia vascular. Las
crisis epilépticas pueden incrementar la mortalidad
del ictus en fase aguda y a largo plazo empeorar
las secuelas funcionales.
Únicamente existe un estudio que valora de forma
específica el tratamiento de la epilepsia vascular,
con buenos resultados con gabapentina. Por lo
tanto, el tratamiento de la epilepsia vascular deberá
ser el mismo que el de otras epilepsias parciales
en el anciano. En este sentido, los nuevos antiepilépticos
(gabapentina, lamotrigina y levetiracetam)
mejoran la tolerabilidad si los comparamos
con los clásicos y no interaccionan con otros
tipos de fármacos que, por lo general, toman los
pacientes ancianos.
Bibliografía
1. Slapo GD, Lossius MI, Gjertstad L. Poststroke epilepsy: occurrence,
predictors and treatment. Expert Rev Neurotherapeutics.
2006; 6(12): 1801-9.
2. Jamrozik K, Broadhurst RJ, Lai N, Hankey GJ, Burvill PW, Anderson
CS. Trens in the incidence severity and short-term outcome of
stroke in Peth, Western Australia. Stroke. 1999; 30(10): 2105-11.
3. Mauri Llerda JA, Tejero Juste C, Íñiguez Martínez, Morales Asín F.
Epidemiología de los distintos tipos de epilepsia vascular en adultos.
Rev Neurol. 1999; 28(3): 293-6.
4. Ryvlin P, Montavont A, Nighoghossian N. Optimizing therapy of seizures
in stroke patients. Neurology. 2006; 67: S3-S9.
5. Hauser WA, Annegers J, Kurland LT. Incidence of epilepsy and unprovoked
seizures in Rochester, Minnesota: 1935-1984. Epilepsia.
1993; 34: 453-68.
6. Benbir G, Ince B, Bozluolcay M. The epidemiology of poststroke
epilepsy according to stroke subtypes. Acta neurol Scand. 2006;
114: 8-12.
7. Burn J, Dennis M, Bamford J, Sandercock P, Wade D, Warlow C.
Epileptic seizures after a first stroke: the Oxfordshire Community
Stroke Project. BMJ. 1997; 315: 1582-7.
8. Afsar N, Kaya D, Aktan S, Canan AB. Stroke and status epilepticus:
Stroke type, type of status epilepticus and prognosis. Seizure.
2003; 12: 23-7.
9. Velioglu SK, Ozmenoglu M, Boz C,Alioglu Z. Status epilepticus after
stroke. Stroke. 2001; 32: 1169-72.
10. Sun DA, Sombati S, Blair RE, De Lorenzo RJ. Calcium-dependent
epileptogenesis in an in-vitro model of stroke-induced “epilepsy”.
Epilepsia. 2002; 43: 1296-305.
11. Bladin CF, Alexandrov AV, Bellavance A, Bornstein N, Chambers B,
Cote R et al. Seizures after stroke: a prospective multicenter study.
Arch Neurol. 2000; 57(11): 1617-22.
12. Benbir G, Ince B, Bozluolcay M. The epidemiology of poststroke
epilepsy according to stroke subtypes. Acta Neurol Scand. 2006;
114: 8-12.
13. Lossius MI, Ronning OM, Slapo GD, Mowinckel P, Gjerstad L. Poststroke
epilepsy: occurrence and predictors-a long term prospective
controlled study(Akerhus Stroke Study). Epilepsia. 2005; 46(8):
1246-51.
14. Kilpatrick CJ, Davis SM, Tress BM, Rossiter SC, Hopper JL, Vandendriesen
ML. Epileptic seizures in acute stroke. Arch Neurol. 1990;
47(2): 157-60.
15. De Reuck JL. Stroke-related seizures and epilepsy. Neurología I
Neurochirurgía polska. 2007; 41(2): 144-9.
16. Labovitz DL, Hauser WA, Sacco RL. Prevalence ans predictors of
early seizure and status epilepticus after first stroke. Neurology.
2001; 57: 200-6.
17. Kammersgaard LP, Olsen TS. Poststroke epilepsy in the Coppenhagen
Stroke Study: incidence and predictors. J Stroke Cerebrovasc
Dis. 2005; 14(5): 210-4.
18. Devuyst G, Karapanayiotides G, Hottinger I, Melle V, Bogousslavsky J.
Prodromal and early epileptic seizures in acute stroke, Does higher
serum cholesterolprotect? Neurology. 2003; 61: 249-52.
19. Cordonnier C, Henon H, Derambure P, Pasquier F, Leys D. Influence
of preexisting dementia on the risk of post-stroke epileptic seizures.
J Neurol Neurosurg Psychiatry. 2005; 76: 1649-53.
20. Cordonnier C, Henon H, Derambure P, Pasquier F, Leys D. Early epileptic
seizures after stroke are associated with increased risk of newonset
dementia. J Neurol Neurosurg Psychiatry. 2007; 78: 514-6.
21. Giroud M, Gras P, Fayolle H, Andre N, Soichot P, Dumas R. Early seizures
after acute stroke. Astudy of 1640 cases. Epilepsia. 1994;
35. 959-64.
22. Ferro JM, Pinto F. Poststroke Epilepsy. Epidemiology, Pathofisiology
and management. Drugs Aging. 2004; 21(10): 639-53.
23. Silverman IE, Restrepo L, Mathews GC. Poststroke Seizures. Arch
Neurol. 2002; 59: 195-202.
24. Holmes G. The electroencephalogram as a predictorof seizure
following cerebral infarction. Clin Electroencephalograph. 1980;
11: 83-6.
25. De Reuck J, De Groote L, van Maele G. Delayed transient worsening
of neurological deficits after ischaemic stroke. Cerebrovasc
Dis. 2006; 22. 27-32.
26. Cockerell OC, Jonhson AL, Sander JW, Shorvon SD. Prognosis of
epilepsy: a review and further analysis of the first nine years of
the British National General Practice Study of Epilepsy, a prospective
population-based study. Epilepsia. 1997; 38: 31-46.
27. Álvarez-Sabín J, Montaner J, Padró L, Molina CA, Rovira R, Codina
A. Gabapentin in late-onset poststroke seizures. Neurology. 2002;
59: 1991-3.
28. Marson A, Jacoby A, Jonhson A, Kim L, Gamble C, Chadwick D. Inmediate
versus deferred antiepileptic drug therapy for early epilepsy
and single seizures: a randomized controlled trial. Lancet.
2005; 365: 2007-13.
29. Annegers JF, Hauser WA, Elveback LR. Remission of seizures and
relapse in patients with epilepsy. Epilepsia. 1979; 20: 729-37.
30. Cloyd J, Hauser W, Towne A, Ramsay R, Mattson R, Gillian F.
Epidemiological and medical aspects of epilepsy in the elderly.
Epilepsy Res. 2006; 68(Suppl 1): S39-48.
31. Osserman M, Bruls V, V. De Borchgrave C, De Cock C, Delvaux C,
Depondt C, et al. Guideliness for the management of epilepsy in
the elderly. Acta Neurol Belg. 2006; 106: 111-6.
32. Brodie MJ, Stephen LJ. Outcomes in elderly patients with newly
diagnosed and treated epilepsy. International Review of Neurobiology.
2007; 81: 253-63.
33. Garrad J, Harms S, Hardie N.Antiepileptic drug use in nursing home
admissions. Ann Neurol. 2003; 54: 75-85.
34. Lackner T, Cloyd J, Thomas L. Antiepileptic drug use in nursing
home residents: effect of age, gender and comedication on patterns
of use. Epilepsia. 1998; 39: 1083-7.
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REVISTA DEL GRUPO DE EPILEPSIA DE LA SEN • JUNIO 2009