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Fisiología, fenotipos, historia natural y diagnóstico del asma

Fisiología, fenotipos, historia natural y diagnóstico del asma

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3- Goteo nasal<br />

posterior<br />

• Riesgo de <strong>asma</strong> <strong>asma</strong> alérgica:<br />

– 42% sensibilización a aeroalergenos<br />

– 46 % tendrán <strong>asma</strong> de base alérgica<br />

– Si es en lactante < 3meses<br />

• 60%<br />

• Si antecedentes directos de atopia 77%<br />

Bergmann. . Clin Exp Allergy 1998; 28: 965-970<br />

Is rhinitis alone or associated with atopic<br />

eczema a risk factor for severe asthma in<br />

children?<br />

Atopia: factor de riesgo de persistencia<br />

y severidad <strong>del</strong> <strong>asma</strong><br />

edad en<br />

años<br />

7<br />

5<br />

3<br />

1<br />

Pediatr Allergy Immunol 2005: 16: 121–125.<br />

Wilson. Clin Exp Allergy 1994<br />

24:522-529<br />

0 20 40 60 80<br />

Siblancias el año previo<br />

no atopia<br />

atopia<br />

Atopia factor de riesgo <strong>del</strong> <strong>asma</strong><br />

Factores de riesgo<br />

más de 5+<br />

pólenes<br />

epitelios<br />

hongos<br />

ácaros<br />

<strong>asma</strong> leve moderada severa<br />

Croner. Allergy 1992;47: 150-57<br />

Relationships between duration of asthma and asthma severity among children in<br />

the Childhood Asthma Management Program (CAMP) (J Allergy Clin Immunol<br />

1999;103:376-87.)<br />

31

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