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revista chilena de psiquiatria y neurologia de la infancia

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Año 18<br />

Nº 2<br />

Trastorno afectivo bipo<strong>la</strong>r: Evaluación <strong>de</strong> cambios funcionales cerebrales a partir <strong>de</strong> <strong>la</strong> técnica Neuro-SPECT<br />

rían diversas estructuras vincu<strong>la</strong>das a <strong>la</strong> modu<strong>la</strong>ción<br />

afectiva. Especialmente relevantes<br />

resultan <strong>la</strong> hiper-perfusión <strong>de</strong>l área ejecutiva<br />

(área 8, 9 y 10 <strong>de</strong> Brodman), Tá<strong>la</strong>mo, Caudado<br />

y núcleo Lentiforme como partes <strong>de</strong> un complejo<br />

circuito <strong>de</strong> estructuras neo-corticales y<br />

sub-cortico-límbicas. Estos resultados <strong>de</strong>ben<br />

compren<strong>de</strong>rse en el contexto <strong>de</strong> <strong>la</strong> teoría <strong>de</strong><br />

sincronía <strong>de</strong> fase e integración a gran esca<strong>la</strong><br />

<strong>de</strong> Vare<strong>la</strong> [36].<br />

Agra<strong>de</strong>cimientos: Los autores <strong>de</strong>sean agra<strong>de</strong>cer<br />

al Dr. Pedro Torres por evaluación <strong>de</strong><br />

algunos pacientes bipo<strong>la</strong>res presentados en<br />

este trabajo, igualmente, a <strong>la</strong> Sra. Lei<strong>la</strong> De Souza<br />

Coelho por asistencia técnica y a <strong>la</strong> Srta, Ximena<br />

Olivares por ayuda en <strong>la</strong> preparación <strong>de</strong><br />

este manuscrito.<br />

BIBLIOGRAFIA<br />

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signal transduction processes in bipo<strong>la</strong>r<br />

affective disor<strong>de</strong>rs: a synopsis. Journal<br />

Affect Disord, 62: 101-111<br />

2. Aggleton JP (1993) The contribution of the<br />

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3. Akiskal HS et al. (1979) Cyclothymic temperamental<br />

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Am, 2:527-554.<br />

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Study. Arch Gen Psychiatry, 44:461-469<br />

6. Andrew L Stoll et al. (2000) Neuroimaging<br />

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Biol Psychiatry, 48: 505-517<br />

7. Baron et al. (1987) Genetic linkage between<br />

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12. Cummings JL (1993) Frontal-subcortical<br />

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13. Damasio AR (1994) Descate’s Error: Emotion,<br />

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14. Damasio AR (1999) The feeling of what happened.<br />

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15. Delvenne V et al. (1990) Regional cerebral<br />

blood flow in patients with affective disor<strong>de</strong>rs.<br />

Br J Psychiatry, 157: 359-365<br />

16. Duncan J (November, 2001) An adaptive<br />

coding mo<strong>de</strong>l of neural function in prefrontal<br />

cortex. Nature, 2: 820-829<br />

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research on bipo<strong>la</strong>r disor<strong>de</strong>rs in the new<br />

millennium. Bipo<strong>la</strong>r Disor<strong>de</strong>rs, 2: 302-303<br />

18. Hantouche EG et al. (1998) Systematic clinical<br />

methodology for validating bipo<strong>la</strong>r II<br />

disor<strong>de</strong>r. J Affect Disord, 50: 163-173<br />

19. Hirschfeld RMA et al. (2002) Lifetime prevalence<br />

of bipo<strong>la</strong>r I and II disor<strong>de</strong>rs in the<br />

United States. Presented at the 155th Annual<br />

Meeting of the American Psychiatric<br />

Association, Phi<strong>la</strong><strong>de</strong>lphia<br />

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system and prefrontal cortex in <strong>de</strong>pression:<br />

SPECT with anatomic standarization<br />

technique. J Nucl Med, 37:410-414<br />

21. Kan<strong>de</strong>l ER (2000) Principles of Neural<br />

Science.McGraw-Hill<br />

22. Kelsoe JR (2003) Arguments for the genetics<br />

basis of the bipo<strong>la</strong>r spectrum. Journal<br />

Affect Disord, 73:183-197<br />

23. Kessler RC et al. (1994) Lifetime and 12-<br />

month prevalence of DSM-IIIR psychiatric<br />

disor<strong>de</strong>rs in the United States: results from<br />

the National Comorbidity Survey. Arch Gen<br />

Psychiatry, 51: 8-19<br />

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(NMDA) survey of bipo<strong>la</strong>r members. J<br />

Affect Disord, 31: 281-294.<br />

54

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